Physician’s Profile

Adam D. Griesemer, MD

Director, Large Animal Xenotransplantation Laboratory, Columbia Center for Translational Immunology
Komansky Center for Children's Health
NewYork-Presbyterian/Morgan Stanley Children's Hospital
NewYork-Presbyterian/Weill Cornell
Contact Phone: 
(212) 305-9691
Board Certificates: 
Transplant Hepatology
Pediatric Transplant Hepatology
Pediatric Transplant Surgery
Portal Hypertension
Minimally Invasive Surgery
Living Donor Liver Surgery

AASLD Career Development Award in Liver Transplantation, 2015

Forde Award for Research, Columbia University, 2013

Department of Surgery's Chairman's Research Award, Columbia University College of Physicians and Surgeons, 2013

Louis V. Gerstner, Jr. Scholar – Research Award, Columbia University College of Physicians and Surgeons, 2013

Blakemore Prize - Best Resident Research Award, Columbia University College of Physicians and Surgeons, 2011

Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons, 2009

American Society of Transplantation Young Investigator Award, Transplantation Biology Research Center, Harvard Medical School, 2008

International Xenotransplantation Travel Grant, Transplantation Biology Research Center, Harvard Medical School, 2007

American Society of Transplantation/JDRF Research Fellowship Award, Transplantation Biology Research Center, Harvard Medical School, 2005

Alpha Omega Alpha, University of Missouri-Columbia School of Medicine, 2003

Marion DeWeese Award for Excellence in General Surgery, University of Missouri-Columbia School of Medicine, 2003

Donald Silver Award for Excellence in Vascular Surgery, University of Missouri-Columbia School of Medicine, 2003

Use of Tregs to control natural antibody responses and facilitate xenogeneic bone marrow engraftment
Xenogeneic tolerance induction via mixed chimerism and thymus transplant
Allogeneic tolerance induction
Control of humoral rejection
Small for Size Syndrome after Living Donor Liver Transplantation
Lab Members: 
Paula Alonso-Guallart, DVM
Sulemon Chaudry, MD
Jeffery Stern, MD
Joshua Weiner, MD, Former Lab Member
Thome J, Bickham K, Ohmura Y, Kubota M, Matsuoka N, Gordon C, Granot T, Griesemer A, Lerner H, Kato T, and Farber D. Compartmentalization of infant T-cell differentiation and regulation in human tissues. Nature Medicine. Accepted - In Press
Soubrane O, Rougemont O, Kim K, Samstein B, Mamode N, Boillot O, Troisi R, Scatton O, Cauchy F, Lee S, Griesemer A, Ahmed Z, Clavien P, and Cherqui D. Laparoscopic Living Donor Left Lateral Sectionectomy: a New Standard Practice for Donor Hepatectomy. Annals of Surgery. Accepted – In Press.
Parekh M, Kluger M, Griesemer A, and Bentley-Hibbert S. Regenerative Liver Surgeries: The alphabet soup of emerging techniques. American Journal of Roentgenology. Accepted – In Press
Weiner J, Griesemer A, Island E, Lobritto S, Martinez M, Selvaggi G, Lefkowitch J, Velasco M, Tryphonopoulos P, Emond J, Tzakis A, Kato T. Long-Term Outcomes of Auxiliary Partial Orthotopic Liver Transplantation in Pre-Adolescent Children with Fulminant Hepatic Failure. Liver Transpl. 2015 Oct 19. PMID: 26479577
Matsuoka N, Weiner JI, Griesemer AD, Samstein BB, Zhao Y, et al. Ex Vivo Pancreaticoduodenectomy and Liver Autotransplantation for Pancreatic Head Tumor with Extensive Involvement of the Hepatoduodenal Ligament. Liver Transplantation. 2015; PMID: 26289503
Samstein B, Griesemer A, Cherqui D, Mansour T, Pisa J, et al. Fully laparoscopic left-sided donor hepatectomy is safe and associated with shorter hospital stay and earlier return to work: A comparative study. Liver Transplantation. 2015; 21(6):768-73.PMID: 25789460
Weiner J, Duran-Struuck R, Zitsman J, Buhler L, Sondermeijer H, McMurchy A, Levings MK, Sykes M, Griesemer A. Restimulation after cryopreservation and thawing preserves the phenotype and function of expanded baboon regulatory T cells. Transplantation Direct. 2015 February; 1(1):1-7.
Wang H, Griesemer AD, Parsons RF, Graham JA, Emond JC, Samstein B. Delayed Gastric Emptying after Living donor Hepatectomy for Liver Transplantation. Case Reports in Transplantation. 2014. PMID: 25610698 PMCID: PMC4291134
Halazun KJ, Patzer RE, Rana AA, Verna EC, Griesemer AD, Parsons RF, Samstein B, Guarrera JV, Kato T, Brown RS Jr, Emond JC. Standing the test of time: Outcomes of a decade of prioritizing patients with HCC, results of the UNOS natural geographic experiment. Hepatology. 2014 Jun 20. PMID: 24954365
Weiner J, Wu J, Martinez M, Lobritto S, Ovchinsky N, Rohde C, Griesemer A, Kato T. The use of bi-planar tissue expanders to augment abdominal domain in a pediatric intestinal transplant recipient. Pediatr Transplant. 2014 Aug;18(5):E174-9. PMID: 25041331
Samstein B, Cherqui D, Guarrera J, Griesemer A, Halazun KJ, Kato T, Emond JE. Totally laparoscopic full left hepatectomy for living donor liver transplantation in adolescents and adults. Am J Transplant. 2013 Sept: 13: 2462–2466.
Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Moran S, Sachs DH Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers. Am J Transplant. 2011 Dec;11(12):2603-12. PMID:21929644.
Hirakata A, Okumi M, Griesemer AD, Shimizu A, Nobori S, Tena A, Moran S, Arn S, Boyd RL, Sachs DH, Yamada K. Reversal of age-related thymic involution by an LHRH agonist in miniature swine. Transpl Immunol. 2010 Oct;24(1):76-81. PMID: 20692342.
Griesemer AD, Sorenson EC, Hardy MA. The Role of the Thymus in Tolerance. Transplantation. 2010 Sep 15;90(5):465-74. PMID: 20555306.
Griesemer A, Widmann W, Forde KA, Hardy MA. John Jones, MD. Pioneer, Patriot and Founder of American Surgery. World J Surg. 2010 Apr;34(4):605-9. PMID: 20012608.
Weiner J, Scalea J, Ishikawa Y, Okumi M, Griesemer A, Hirakata A, Etter J, Gillon B, Moran S, Shimizu A, Yamada K, Sachs DH. Tolerogenicity of Donor Major Histocompatibility complex-matched Skin Grafts in Previously Tolerant Massachusetts General Hospital Miniature Swine. Transplantation. 2012 Dec 27;94(12):1192-9. PMID:23269447.
Tena A, Vallabhajosyula P, Hawley RJ, Griesemer A, Yamada K, Sachs DH. Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay. Transplantation. 2011 Mar 27;91(6):639-44. PMID: 21285918.
Griesemer A, Liang F, Hirakata A, Hirsh E, Lo D, Okumi M, Sykes M, Yamada K, Huang CA, Sachs DH. Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons. Xenotransplantation. 2010 Jul;17(4):300-12. PMID: 20723202.
IshikawaY, Hirakata A, Griesemer A, Etter J, Moran S, Weiner J, Shimizu A, Yamada K. Tolerance and long-lasting peripheral chimerism following allogeneic intestinal transplantation in MGH miniature swine. Transplantation. 2010 Feb 27;89(4):417-26. PMID: 20177343.
Griesemer A, Hirakata A, Shimizu A, Moran A, Tena A, Iwaki H, Ishikawa Y, Schule P, Arn J, Robson S, Fishman J, Sykes M, Sachs D, Yamada K. Results of Gal-Knockout porcine thymokidney xenografts. Am J Transplant. 2009 Dec;9(12):2669-78. PMID: 19845583.
Griesemer A, Yamada K, and Sachs DH. “Strategies for Immune Tolerance Induction in Islet Transplantation and Xenotransplantation” Chapter in Islets: Biology, Immunology, and Clinical Transplantation Dr. Fouad Kandeel, Editor, In Press. ISBN-10: 0387795774.
Griesemer AD, Okumi M, Shimizu A, Moran S, Ishikawa Y, Iorio J, Arn JS, Yamada K. Upregulation of CD59: potential mechanism of accommodation in a large animal model. Transplantation. 2009 May 15;87(9):1308-17. PMID: 19424030.
Knosalla C, Yazawa K, Behdad A, Bodyak N, Shang H, Bühler L, Houser S, Gollackner B, Griesemer A, Schmitt-Knosalla I, Schuurman HJ, Awwad M, Sachs DH, Cooper DK, Yamada K, Usheva A, Robson SC. Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. Am J Transplant. 2009 May;9(5):1006-16. PMID: 19422330.
Mii A, Shimizu A, Masuda Y, Fujita E, Aki K, Ishizaki M, Sato S, Griesemer A, Fukuda Y. Current status and issues of C1q nephropathy. Clin Exp Nephrol. Clin Exp Nephrol. 2009 Aug;13(4):263-74. PMID: 19373520.
Issa NC, Wilkinson RA, Griesemer A, Cooper DK, Yamada K, Sachs DH, Fishman JA. Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation. Journal of Virology. 2008 Dec;82(24):12441-8. PMID: 18829759.
Griesemer AD, Lamattina JC, Okumi M, Etter JD, Shimizu A, Sachs DH, Yamada K. Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model. Journal of Immunology. 2008 Sep 15;181(6):4027-36. PMID: 18768858.
Oku M, Okumi M, Sahara H, Hirakata A, Onoe T, Griesemer AD, Yamada K. Porcine CFSE mixed lymphocyte reaction and PKH-26 cell-mediated lympholysis assays. Transplant Immunology. 2008 Nov;20(1-2):78-82. PMID: 18718865.
Okumi M, Fishbein JM, Griesemer A, Gianello PR, Hirakata A, Nobori S, Moran S, Samelson-Jones E, Shimizu A, Sachs DH, Yamada K. Breaking tolerance to kidney allografts in miniature swine I. Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts. Transplantation 2008 Jan; 85(2): 270-208. PMID: 18212633
Vallabhajosyula P, Griesemer A, Yamada K, Sachs DH. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochemistry and Biophysics 2007 48:2-3, 201. PMID: 17709890.
Yamada K, Griesemer A, Sykes M, Sachs DH. Cotransplantation of vascularized thymus and kidney from GalT-KO pigs to baboons. Xenotransplantation. 2007 Mar;14(2):186-9.
Nobori S, Shimizu A, Okumi M, Samelson-Jones E, Griesemer A, Hirakata A, Sachs DH, Yamada K. Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19081-6. PMID: 17148614.
Wong BS, Yamada K, Okumi M, Weiner J, O'Malley PE, Tseng YL, Dor FJ, Cooper DK, Saidman SL, Griesemer A, Sachs DH. Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists. Transplantation. 2006 Aug 15;82(3):314-9. PMID: 16906027.
Yamada K, Griesemer A, Okumi M. Pigs as xenogeneic donors. Transplantation Reviews, 2005 June, 19(3) pp. 164-177.
Griesemer A. Emond J. Laparoscopy for cystic parasitic and non-parasitic disease of the liver. Invited expert comment in: Gagner M, Assalia A, and M Schein, eds. Controversies in Laparoscopic Surgery, 2004.
Losanoff JE, Richman BW, Foerst JR, Griesemer AD, Mundis GM, Jones JW. Nonspecific ulcers of the colon. Endoscopy. 2003 Jun;35(6):521-5. PMID: 12783352
Fuchimoto Y. Huang CA. Yamada K. Gleit ZL. Kitamura H. Griesemer A. Scheier-Dolberg R. Melendy E. White-Scharf ME. Sachs DH. Induction of kidney allograft tolerance through mixed chimerism in miniature swine. Transplantation Proceedings. 33(1-2):77, 2001 Feb-Mar. PMID: 11266710.
Fuchimoto Y. Huang CA. Gleit ZL. Kitamura H. Griesemer A. Melendy E. Scheier-Dolberg R. White-Scharf ME. Sachs DH. Mixed chimerism using a nonmyelosuppressive regimen in miniature swine. Transplantation Proceedings. 33(1-2):118-9, 2001 Feb-Mar. PMID: 11266736.
Huang CA. Fuchimoto Y. Gleit ZL. Ericsson T. Griesemer A., Scheier-Dolberg R. Melendy E. Kitamura H. Fishman JA. Ferry JA. Harris NL. Patience C. Sachs DH. Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus. Blood. 97(5):1467-73, 2001 Mar 1. PMID: 11222395.
Mumm JS. Schroeter EH. Saxena MT., Griesemer A. ,Tian X. Pan DJ. Ray WJ. Kopan R. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Molecular Cell. 5(2):197-206, 2000 Feb. PMID: 10882062.