Master Regulator Analysis in Breast Cancer Patients

Protocol: 
AAAN9005
Phase: 
II

Master regulator analysis to prioritize treatment of residual disease following neoadjuvant chemotherapy for breast cancer in patient-derived tumor xenografts

Determine whether master regulator-directed therapy will demonstrate a greater reduction of tumor growth in patient-derived xenografts from tumors resistant to neoadjuvant taxane therapy [i.e. paclitaxel or docetaxel +/- adriamycin/cytoxan] as compared to taxane (i.e. control).

Are you Eligible? (Inclusion Criteria)

Patients with breast cancer who have been treated with standard neoadjuvant chemotherapy who fail to have a complete response prior to surgery.

Specialty Area(s)

Trial Location

Columbia University Medical Center
New York, NY 10032
United States