Immunology Presentations and Research

This quarterly report is a summary of the monthly Faculty Research Newsletter. Journal links may require subscriptions or a log-in through the Columbia library while PubMed links are accessible to all.

Presentations

November 2017

Third International Workshop on Clinical Tolerance, Stanford University
California, September 8-9, 2017

  • Session 6: Update on immune monitoring of tolerance trials. Megan Sykes, Clonal Deletion and Immune Regulation in Clinical Tolerance Trials

International Xenotransplantation Association 14th Congress
Baltimore, MD, September 20-23, 2017

  • Megan Sykes, Honorary Member Lecture. The Future of Xenotransplantation
  • David Sachs, Mixed Chimerism from Allograft to Xenograft

ESOT 2017 Transplantation BigBangBarcelona
Barcelona, Spain, September 23-27, 2017

  • Educational Track Session 4: Pathophysiology and Endpoints on Tolerance; Megan Sykes, New York, United States “Clinical tolerance studies”

XVII Great Lakes Transplant Immunology Forum
Madison, Wisconsin, October 12-13, 2017

  • Special Guest & Charles G. Orosz lecturer; Megan Sykes, “Combined TCR sequencing and phenotyping to understand dynamics of human allograft lymphocyte turnover, establishment of tissue resident memory and tolerance.”

The Japanese Society for Histocompatibility and Immunogenetics 26th Annual Meeting
Hiroshima, Japan, October 27-28, 2017

  • Keynote Lecturer, Megan Sykes: Toward the comprehensive understanding of human alloresponse and immune tolerance

April 2017

University of Toronto Charles Easton Seminar Series
February 13, 2017

  • Sykes, M. Tracking the human alloresponse in transplant recipients

December 2016

American Association for the Study of Liver Disease, Boston, MA
November 11-15, 2016

  • Guarrera J: Debate: In 10 Years Liver Machine Perfusion will be Universal (PRO)
  • Gurarrera J. Innovation in Liver Transplantation: Hypothermic Machine Perfusion

November 2016

Symposium on Regenerative Medicine. Hallym-Uppsala Internation Symposium, Seoul, Korea
September 30, 2016

  • M. Hardy, moderator

Publications

February 2018

  • Sahara H, Sekijima M, Ariyoshi Y, Kawai A, Miura K, Waki S, Nathan L, Tomita Y, Iwanaga T, Nakano K, Matsunari H, Date H, Nagashima H, Shimizu A, Yamada K. Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys. Xenotransplantation. 2017 Oct 25. doi: 10.1111/xen.12359. [Epub ahead of print]
    Journal link | PubMed link
  • Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation. Cell Transplant. 2017 Nov;26(11):1755-1762. doi: 10.1177/0963689717732993.
    Journal link | PubMed link
  • Yamada K, Shah JA, Tanabe T, Lanaspa MA, Johnson RJ. Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Curr Transplant Rep. 2017 Jun;4(2):101-109.
    Journal link | PubMed link

January 2018

  • Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN 3rd, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR. Miscellaneous. Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12365. Epub 2017 Nov 28.
    Journal link | PubMed link
  • Rahnemai-Azar AA, Griesemer AD, Velasco ML, Kato T. Ex vivo excision of retroperitoneal soft tissue tumors: A case report. Oncol Lett. 2017 Oct;14(4):4863-4865.
    PubMed link | Journal link
  • Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. The neonatal window of opportunity — early priming for life. J Allergy Clin Immunol. 2017 Dec 13. pii: S0091-6749(17)31895-X. doi: 10.1016/j.jaci.2017.11.019. [Epub ahead of print]
    Journal link | PubMed link

December 2017

  • Borsotti C, Danzl NM, Nauman G, Hölzl MA, French C, Chavez E, Khosravi-Mararlooei M, Glauzy S, Delmotte FR, Meffre E, Savage DG, Campbell SR, Goland R, Greenberg E, Bi J, Satwani P, Yang S, Bathon J, Winchester R, Sykes M. HSC-extrinsic sex-related and intrinsic autoimmune disease-related human B cell variation is recapitulated in humanized mice. Blood Advances 2017 1:2007-2018;
    Journal link
  • Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6.
    Journal link | PubMed link
  • Kumar BV, Ma W, Miron M, Granot T, Guyer RS, Carpenter DJ, Senda T, Sun X, Ho SH, Lerner H, Friedman AL, Shen Y, Farber DL. Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.
    Cell Rep. 2017 Sep 19;20(12):2921-2934. doi: 10.1016/j.celrep.2017.08.078.
    Journal link | PubMed link
  • Meng W, Zhang B, Schwartz GW, Rosenfeld AM, Ren D, Thome JJC, Carpenter DJ, Matsuoka N, Lerner H, Friedman AL, Granot T, Farber DL, Shlomchik MJ, Hershberg U, Luning Prak ET. An atlas of B-cell clonal distribution in the human body. Nat Biotechnol. 2017 Sep;35(9):879-884. doi: 10.1038/nbt.3942. Epub 2017 Aug 21.
    Journal link | PubMed link
  • Zens KD, Chen JK, Guyer RS, Wu FL, Cvetkovski F, Miron M, Farber DL. Reduced generation of lung tissue-resident memory T cells during infancy. J Exp Med. 2017 Oct 2;214(10):2915-2932. doi: 10.1084/jem.20170521. Epub 2017 Aug 30.
    Journal link | PubMed link
  • Zens KD, Connors T, Farber DL. Tissue compartmentalization of T cell responses during early life. Semin Immunopathol. 2017 Sep 11. doi: 10.1007/s00281-017-0648-7. [Epub ahead of print] Review.
    Journal link | PubMed link

November 2017

  • DeWolf S, Sykes M. Alloimmune T cells in transplantation. J Clin Invest. 2017 Jun 30;127(7):2473-2481. doi: 10.1172/JCI90595. Epub 2017 Jun 19.
    Journal link | PubMed Link
  • Sondermeijer H, Witkowski P, Seki T, van der Laarse A, Itescu S, Hardy MA.
    RGDfK-peptide modified alginate scaffold for cell transplantation and cardiac neovascularization. Tissue Eng Part A. 2017 Sep 22. doi: 10.1089/ten.TEA.2017.0221
    Journal link | PubMed Link
  • Zuber J, Sykes M. Mechanisms of Mixed Chimerism-Based Transplant Tolerance. Trends Immunol. 2017 Aug 18. pii: S1471-4906(17)30146-1. doi: 10.1016/j.it.2017.07.008. [Epub ahead of print]
    Journal link | PubMed Link

October 2017

  • Sahara H, Watanabe H, Pomposelli T, Yamada K. Lung xenotransplantation. Curr Opin Organ Transplant. 2017 Sep 1. doi: 10.1097/MOT.0000000000000465. [Epub ahead of print]
    Journal link | PubMed link
  • Sekijima M, Sahara H, Miki K, Villani V, Ariyoshi Y, Iwanaga T, Tomita Y, Yamada K. Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine. Journal of Surgical Research, Vol 219, November 2017, Pages 165-172.
    Journal link
  • Yamada K, Sykes M, Sachs DH. Tolerance in xenotransplantation. Curr Opin Organ Transplant. 2017 Sep 20. doi: 10.1097/MOT.0000000000000466. [Epub ahead of print]
    Journal link | PubMed link

September 2017

  • Carpenter, D.J., Matsuoka, N., Granot, T., Kumar, B.V., Senda, T., Thome, J.J.C., Gordon, C.L., Miron, M., Weiner, J., Lerner, H., Friedman, A., Griesemer, A.D., Farber, D.L. (2017) Human immunology studies using organ donors: impact of clinical variations on immune parameters in tissues and circulation. Am. J. Trans. doi: 10.1111/ajt.14434. [Epub ahead of print]. NB: A surgery resident is first author/startup grant and award recipient
    Journal link | PubMed link
  • Granot, T., Senda, T., Carpenter, D., Matsuoka, N., Weiner, J., Gordon, C.L., Miron, M., Kumar, B.V., Griesemer, A., Ho, S-H, Lerner, H., Thome, J.J.C., Connors, T., Reizis, B., and Farber, D.L. (2017) Dendritic cells display subset and tissue-specific maturation dynamics over human life. Immunity, 46:504-515.
    Journal link | PubMed link
  • Gordon, C.L., Miron, M., Thome, J.J.C., Matsuoka, N., Weiner, J., Rak, M., Igarashi, S., Granot, T., Lerner, H., Goodrum, F. and Farber, D.L. (2017) Tissue-reservoirs of T cell immunity in persistent human CMV infection. J. Exp. Med. 214:651-667.
    Journal link | PubMed link
  • Snyder, M.E. and Farber, D.L. (2017) Thymic-peripheral crosstalk in lymphoodepletion therapy. Am. J. Trans. 17:1970-1971.
    Journal link | PubMed link

July 2017

  • Shah JA, Tanabe T, Yamada K. Role of Intrinsic Factors in the Growth of Transplanted Organs Following Transplantation J Immuno Biol 2017, 2 (2): 122.1-14.
    Journal link | PubMed link
  • Shah JA, Patel MS, Elias N, Navarro-Alvarez N, Rosales I, Wilkinson RA, Louras NJ, Hertl M, Fishman JA, Colvin RB, Cosimi AB, Markmann JF, Sachs DH, Vagefi PA. Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade. Am J Transplant. 2017 May 10. doi: 10.1111/ajt.14341. [Epub ahead of print]
    Journal link | PubMed link
  • Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K. Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation. Am J Transplant. 2017 Jan 24. doi: 10.1111/ajt.14210. [Epub ahead of print]
    Journal link | PubMed link
  • Yamada K, ShahJA, Tanabe T, Lanaspa MA, Johnson RJ Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Current Transplantation Reports. 2017 June: 4 (2): 101-109.
    Journal link

Book Chapter

  • Kazuhiko Yamada*, Masayuki Tasaki, Adam Griesemer and Jigesh Shah, Kidney Transplantation, Bioengineering, and Regeneration 1st Edition -Kidney Transplantation in the Regenerative Medicine Era Chapter 84: Xenotransplantation and Kidney Regenerative technology Eds: Giuseppe Orlando, Giuseppe Remuzzi, David Williams. Publisher: AP – Elsevier. eBook ISBN: 9780128018361, Hardcover ISBN: 9780128017340.

April 2017

  • Duran-Struuck R, Buhler L, Alonso-Guallart P, Zitsman J, Kato Y, Wu A, McMurchy A, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi A, Wuu C, Slate A, Mapara M, Baker S, Tokarz R, D’Agati V, Hammer S, Pereira M, Lipkin W, Wekerle T, Levings M, Sykes M. Effect of ex vivo expanded recipient regulatory T cells on hematopoietic chimerism and kidney allograft tolerance across MHC barriers in cynomolgus macaques. Transplantation. 2017 Feb;101(2):274-283 2016.
    Journal link
  • Halazun KJ, Najjar M, Abdelmessih RM, Samstein B, Griesemer AD, Guarrera JV,Kato T, Verna EC, Emond JC, Brown RS Jr. Recurrence After Liver Transplantationfor Hepatocellular Carcinoma: A New MORAL to the Story. Ann Surg. 2017
    Mar;265(3):557-564.
    Journal link
  • Pathiraja V, Villani V, Tasaki M, Matar AJ, Duran-Struuck R, Yamada R, Moran SG, Clayman ES, Hanekamp J, Shimizu A, Sachs DH, Huang CA, Yamada K. Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys. Am J Transplant. 2017
    Jan;17(1):91-102.
    Journal link | Pubmed link
  • Salerno DM, Tsapepas D, Papachristos A, Chang JH, Martin S, Hardy MA, McKeen J. Direct oral anticoagulant considerations in solid organ transplantation: A review. Clinical transplantation. 2017 January;31(1).
    Journal link | Pubmed link
  • Sprangers B, DeWolf S, Savage TM, Morokata T, Obradovic A, LoCascio SA, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer FI, Olek S, Dombkowski DM, Turka LA, Colvin R, Winchester R, Kawai T, Sykes M. Origin of
    enriched regulatory t cells in patients receiving combined kidney/bone marrow transplantation to induce transplantation tolerance. American Journal of Transplantation. 2017 Mar. 1, doi: 10.1111/ajt.14251. [Epub ahead of print]
    Journal link | Pubmed link
  • Weiner J, Zuber J, Shonts B, Yang S, Fu J, Martinez M, Farber D, Kato T, Sykes M. Long-term persistence of innate lymphoid cells in the gut after intestinal transplantation. Transplantation. 2016 Dec 8, DOI: 10.1097/TP.0000000000001593.
    [Epub ahead of print] PMC journal.
    Journal link

February 2017

  • DiMartini A, Dew MA, Liu Q, Simpson MA, Ladner DP, Smith AR, Zee J, Abbey S, Gillespie BW, Weinrieb R, Mandell MS, Fisher RA, Emond JC, Freise CE, Sherker AH, Butt Z. Social and Financial Outcomes of Living Liver Donation: A Prospective Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2). Am J Transplant. 2016 Sep 20. doi: 10.1111/ajt.14055. [Epub ahead of print]
    Journal link | Pubmed link
  • Eliaz I, Patil A, Navarro-Alvarez N, Wang Z, Eliaz A, Weil E, Wilk B, Sachs DH, Huang CA. Methods for the detection and serum depletion of porcine galectin-3. J Clin Apher. 2017 Jan 13. doi: 10.1002/jca.21521. [Epub ahead of print]
    Journal link | Pubmed link
  • Emond JC. Laparoscopic donor hepatectomy: a way forward? Transplantation. 2016 Nov 15. [Epub ahead of print] No abstract available.
    Journal link | Pubmed link
  • Emond JC, Griesemer AD. Tolerance in clinical liver transplantation: The long road ahead. Hepatology. 2017 Feb;65(2):411-413. doi: 10.1002/hep.28862.
    Journal link | Pubmed link
  • Furr A, Hardy MA, Barret JP, Barker JH. Surgical, ethical, and psychosocial considerations in head transplantation. Int J Surg. 2017 Jan 18. pii: S1743-9191(17)30080-8.
    Journal link | Pubmed link
  • Hardy MA, Furr A, Barret JP, Barker JH. The immunologic considerations in head transplantation. Int J Surg. 2017 Jan 24. pii: S1743-9191(17)30088-2.
    Journal link | Pubmed link
  • Shanmugarajah K, Powell H, Leonard DA, Mallard C, Albritton A, Harrington E, Randolph MA, Farkash E, Sachs DH, Kurtz JM, Cetrulo CL Jr. The Effect of MHC Antigen Matching Between Donors and Recipients on Skin Tolerance of Vascularized Composite Allografts. Am J Transplant. 2016 Dec 30. doi: 10.1111/ajt.14189. [Epub ahead of print]
    Journal link | Pubmed link
  • Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K. Role of intrinsic (graft) vs. extrinsic (host) factors in the growth of transplanted organs following allogeneic and xenogeneic transplantation. Am J Transplant. 2017 Jan 24. doi: 10.1111/ajt.14210. [Epub ahead of print]
    Journal link | Pubmed link

December 2016

  • Ali ZA, Karimi Galougahi K, Nazif T, Maehara A, Hardy MA, Cohen DJ, Ratner LE, Collins MB, Moses JW, Kirtane AJ, Stone GW, Karmpaliotis D, Leon MB. Imaging- and physiology-guided percutaneous coronary intervention without contrast administration in advanced renal failure: a feasibility, safety, and outcome study. Eur Heart J. 2016 Oct 21;37(40):3090-3095.
    Journal link | Pubmed link
  • Duran-Struuck R, Sondermeijer HP, Bühler L, Alonso-Guallart P, Zitsman J, Kato Y, Wu A, McMurchy AN, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi AB, Wuu CS, Slate A, Mapara M, Baker S, Tokarz R, D, Agati V, Hammer S, Pereira M, Lipkin WI, Wekerle T, Levings M, Sykes M. Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques. Transplantation. 2016 Nov 15. PMID: 27846155.
    Journal link | Pubmed link
  • Duran-Struuck R, Matar AJ, Crepeau RL, Teague AG, Horner BM, Pathiraja V, Spitzer TR, Fishman JA, Bronson RT, Sachs DH, Huang CA. Donor Lymphocyte InfusionMediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 Nov;22(11):1953-1960.
    Journal link | Pubmed link
  • Halazun KJ, Najjar M, Abdelmessih RM, Samstein B, Griesemer AD, Guarrera JV, Kato T, Verna EC, Emond JC, Brown RS Jr. Recurrence After Liver Transplantation for Hepatocellular Carcinoma: A New MORAL to the Story. Ann Surg. 2016 Sep 16. PMID: 27611615.
    Journal link | Pubmed link
  • Mandell MS, Smith AR, Dew MA, Gordon DB, Holtzman S, Howell T, DiMartini AF, Butt Z, Simpson MA, Ladner DP, Freise CE, McCluskey SA, Fisher RA, Guarrera JV, Olthoff KM, Pomfret EA. Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study.Transplantation. 2016 Nov;100(11):2362-2371.
    Journal link | Pubmed link
  • Quillin RC 3rd, Guarrera JV. "In 10 years" of debate: Pro-machine perfusion for liver preservation will be universal.Liver Transpl. 2016 Nov;22(S1):25-28.
    Journal link | Pubmed link
  • Salerno DM, Tsapepas D, Papachristos A, Chang JH, Martin S, Hardy MA, McKeen J. Direct oral anticoagulant considerations in solid organ transplantation: a review. Clin Transplant. 2016 Nov 16. doi: 10.1111/ctr.12873. [Epub ahead of print] Review.
    Journal link | Pubmed link

November 2016

  • Emond JC, Griesemer AD. Tolerance in clinical liver transplantation: The long road ahead. Hepatology. 2016 Oct 7.
    Journal link | Pubmed link
  • Zuber J, Shonts B, Lau S, Obradovic A, Fu J, Yang S, Lambert M, Coley S, Weiner J, Thome J, DeWolf S, Farber DL, Shen Y, Caillat-Zucman S, Bhagat G, Griesemer A, Martinez M, Kato T, Sykes M. Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome. Science Immunology. 2016 October 07; 1(4)
    Journal link