Immunology Presentations and Research

This quarterly report is a summary of the monthly Faculty Research Newsletter. Journal links within the publications below may require subscriptions or a log-in through the Columbia library while PubMed links are accessible to all.

Presentations

December 2018

American Society of Transplant Surgeons Laparoscopic Donor Nephrectomy Workshop
Denver, CO, November 2-3, 2018

  • Ratner, Lloyd E.: Laparoscopic Live Donor Nephrectomy: Intra-operative Complications, and Difficult and Unusual Cases, Live Donor Deaths, Near Misses and a Systems Approach Towards Improving Safety

Indiana University, Transplant Grand Rounds
Indianapolis, IN, November 2018

  • Ratner, Lloyd E.: Playing the Wild Card: How Policy Development Can Pertain to Metrics, Allocation, Organ Utilization, Access to Transplantation, and Innovation

November 2018

American Society of Transplant Surgeons Winter Symposium
Miami Beach, FL, January 11-14, 2018

  • Ratner, L: 3 Invited Lectures
    –Strategies for Increasing the Number of Transplants: Life-Saving Innovations in Transplantation
    –Kidney Transplantation: How to Get Out of Trouble
    –Laparoscopic Live Donor Nephrectomy: From Someone Who’s Been Around the Block

Controversies in Transplantation University of Colorado
Breckenridge, CO, March 2-4, 2018

  • Ratner, L: Playing the Wild Card: How Policy Development Can Pertain to Metrics, Allocation, Organ Utilization, Access to Transplantation, and Innovation

American Society of Transplant Surgeons Laparoscopic Live Donor Nephrectomy Course, University of Cincinnati
Cincinnati, OH, March 16-17, 2018

  • Ratner, L:
    – Laparoscopic Live Donor Nephrectomy: Intra-operative Complications, Difficult and Unusual Cases
    –Live Donor Deaths, Near Misses and a Systems Approach Towards Improving Safety

Department of Surgery Grand Rounds, State University of New York at Buffalo
Buffalo, NY

  • Ratner, L: How To Innovate & Bring New Ideas to Clinical Reality

Transplant Grand Rounds, Erie County Medical Center
Buffalo, NY

  • Ratner, L: Access to Transplantation: Who Shall Live and Who Shall Die?

15th Hallym-Columbia-Weill Cornell-NYP Symposium Current Status and Future Advances in Organ Transplantation
Hallym University, Seoul, South Korea, June 8, 2018

  • Ratner, L: Access to Transplantation: Who Shall Live and Who Shall Die?

9th International Conference: Living Donor Abdominal Organ Transplantation State of the Art
Matera, Italy, September 1, 2018

  • Ratner, L: 20+ Years of Laparoscopic Live Donor Nephrectomy: Where Have We Been? Where Do We Go?

Education of Young Professionals in Transplantation Workshop
Matera, Italy, August 3-September 1, 2018

  • Ratner, L:
    –What I Have Learned From Near-misses, Major Mishaps & Never Events
    –Laparoscopy in Living Kidney Donation

American Society of Transplant Surgeons 12th Annual Fellows Symposium
Phoenix, AZ, October 5-7, 2018

  • Ratner, L: Regulation

August 2018

Sykes, M. Online Lecture Series: The Immune Response to Allo- and Xenotransplantation:

  • Part 1: Introduction to Transplantation
    Part 2: Taming and Tracking the Human Alloresponse
    Part 3: Xenotransplantation
    Link

June 2018

Turkish Chapter of the American College of Surgeons
May 8-10, 2018

  • Hardy M, The future of transplantation.

European Society of Surgical Research
Madrid, Spain, May 29-June 2, 2018

  • Hardy M, The future of surgical research.

Hallym Columbia Symposium, Hallym University
South Korea, June 8, 2018

  • Hardy M, Moderator, the future of organ replacement and repair.

Hallym University
South Korea, June 12, 2018

  • Hardy M, Progress in xenotransplantation. Invited lecture.

November 2017

Third International Workshop on Clinical Tolerance, Stanford University
California, September 8-9, 2017

  • Session 6: Update on immune monitoring of tolerance trials. Megan Sykes, Clonal Deletion and Immune Regulation in Clinical Tolerance Trials

International Xenotransplantation Association 14th Congress
Baltimore, MD, September 20-23, 2017

  • Megan Sykes, Honorary Member Lecture. The Future of Xenotransplantation
  • David Sachs, Mixed Chimerism from Allograft to Xenograft

ESOT 2017 Transplantation BigBangBarcelona
Barcelona, Spain, September 23-27, 2017

  • Educational Track Session 4: Pathophysiology and Endpoints on Tolerance; Megan Sykes, New York, United States “Clinical tolerance studies”

XVII Great Lakes Transplant Immunology Forum
Madison, Wisconsin, October 12-13, 2017

  • Special Guest & Charles G. Orosz lecturer; Megan Sykes, “Combined TCR sequencing and phenotyping to understand dynamics of human allograft lymphocyte turnover, establishment of tissue resident memory and tolerance.”

The Japanese Society for Histocompatibility and Immunogenetics 26th Annual Meeting
Hiroshima, Japan, October 27-28, 2017

  • Keynote Lecturer, Megan Sykes: Toward the comprehensive understanding of human alloresponse and immune tolerance

April 2017

University of Toronto Charles Easton Seminar Series
February 13, 2017

  • Sykes, M. Tracking the human alloresponse in transplant recipients

December 2016

American Association for the Study of Liver Disease
Boston, MA, November 11-15, 2016

  • Guarrera J: Debate: In 10 Years Liver Machine Perfusion will be Universal (PRO)
  • Gurarrera J. Innovation in Liver Transplantation: Hypothermic Machine Perfusion

November 2016

Symposium on Regenerative Medicine. Hallym-Uppsala Internation Symposium
Seoul, Korea, September 30, 2016

  • M. Hardy, moderator

Publications

December 2018

  • Carpenter DJ, Chiles MC, Verna EC, Halazun KJ, Emond JC, Ratner LE, Mohan S. Deceased brain dead donor liver transplantation and utilization in the United States: nighttime and weekend effects. Transplantation. 2018 Nov 15. doi: 10.1097/TP.0000000000002533.
    Journal link | PubMed link
  • Carpenter D, Husain SA, Brennan C, Batal I, Hall IE, Santoriello D, Rosen R, Crew RJ, Campenot E, Dube GK, Radhakrishnan J, Stokes MB, Sandoval PR, D'Agati V, Cohen DJ, Ratner LE, Markowitz G, Mohan S. Procurement Biopsies in the Evaluation of Deceased Donor Kidneys. Clin J Am Soc Nephrol. 2018 Oct 25. pii: CJN.04150418. doi: 10.2215/CJN.04150418.
    Journal link | PubMed link
  • Kumar BV, Kratchmarov R, Miron M, Carpenter DJ, Senda T, Lerner H, Friedman A, Reiner SL, Farber DL. Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities. JCI Insight. 2018 Nov 15;3(22). pii: 123568. doi: 10.1172/jci.insight.123568.
    Journal link | PubMed link

November 2018

  • Batal I, Mohan S, De Serres SA, Vasilescu ER, Tsapepas D, Crew RJ, Patel SS, Serban G, McCune K, Husain SA, Chang JH, Herter JM, Bhagat G, Markowitz G, D’Agati V, Hardy MA, Ratner L, Chandraker A: Analysis of dendritic cells and ischemia-reperfusion changes in post-implantation renal allograft biopsies may serve as predictors of subsequent rejection episodes. Kid Int 2018, May;93(5):1227-1239.
    Journal link | PubMed link
  • Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S: Characteristics and performance of unilateral kidney transplants from deceased donors. Clin J Am Soc Nephrol 2018, Jan;13(1):118-127.
    Journal link | PubMed
  • Leal R, Tsapepas D, Crew RJ, Dube GK, Ratner L, Batal I: Pathology of calcineurin and mammalian target of rapamycin inhibitors in kidney transplantation. Kid Int Rep 2018, Mar;3(2):281-290.
    Journal link | PubMed link
  • Lefaucheur C, Viglietti D, Hidalgo LG, Ratner LE, Bagnasco SM, Batal I, Aubert O, Orandi BJ, Oppenheimer F, Bestard O, Rigotti P, Reisaeter AV, Kamar N, Lebranchu Y, Van Huyen JPD, Bruneval P, Glotz D, Legendre C, Empana JP, Jouven X, Segev DL, Montgomery RA, Zeevi A, Halloran PF, Loupy A: Complement-activating anti-HLA antibodies in kidney transplantation: allograft gene expression profiling and response to treatment. JASN 2018, Feb;29(2):620-635.
    Journal link | PubMed link
  • Orandi BJ, Luo X, King EA, Garonzik-Wang JM, Bae S, Montgomery RA, Stegall MD, Jordan SC, Oberholzer J, Dunn TB, Ratner LE, Kapur S, Pelletier RP, Roberts JP, Melcher ML, Singh P, Sudan DL, Posner MP, El-Amm JM, Shapiro R, Cooper M, Lipkowitz GS, Rees MA, Marsh CL, Sankari BR, Gerber DA, Nelson PW, Wellen J, Bozorgzadeh A, Gaber AO, Segev DL: Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study. Am J Transplant 2018, Mar;18(3):650-658.
    Journal link | PubMed link
  • Mohan S, Chiles MC, Patzer RE, Pastan SO, Husain SA, Carpenter DJ, Dube GK, Crew RJ, Ratner LE, Cohen DJ: Factors leading to the discard of deceased donor kidneys in the United States. Kid Int 2018, Jul;94(1):1870198.
    Journal link | PubMed link
  • Samstein B, de Melo-Martin I, Kapur S, Ratner L, Emond J: A liver for a kidney: Ethics of trans‐organ paired exchange. Am J Trans 2018, May;18(5): 1077-1082.
    Journal link | PubMed link
  • Schold JD, Andreoni KA, Chandraker AK, Gaston RS, Locke JE, Mathur AK, Pruett T, Rana A, Ratner LE, Buccini LD: Expanding clarity or confusion? Volatility of the five-tier ratings assessing quality of transplant centers in the United States. Am J Trans 2018, Jun;18(6):1494-1501.
    Journal link | PubMed link

September 2018

  • Batal I, Mohan S, De Serres SA, Vasilescu ER, Tsapepas D, Crew RJ, Patel SS, Serban G, McCune K, Husain SA, Chang JH, Herter JM, Bhagat G, Markowitz GS, D'Agati VD, Hardy MA, Ratner L, Chandraker A. Analysis of dendritic cells and ischemia-reperfusion changes in postimplantation renal allograft biopsies may serve as predictors of subsequent rejection episodes. Kidney Int. 2018 May;93(5):1227-1239. doi: 10.1016/j.kint.2017.12.015.
    PubMed link
  • Halazun KJ, Tabrizian P, Najjar M, Florman S, Schwartz M, Michelassi F, Samstein B, Brown RS Jr, Emond JC, Busuttil RW, Agopian VG. Is it Time to Abandon the Milan Criteria?: Results of a Bicoastal US Collaboration to Redefine Hepatocellular Carcinoma Liver Transplantation Selection Policies. Ann Surg. 2018 Jul 24. doi: 10.1097/SLA.0000000000002964.
    Journal link | PubMed link
  • Mohan S, Chiles MC, Patzer RE, Pastan SO, Husain SA, Carpenter DJ, Dube GK, Crew RJ, Ratner LE, Cohen DJ. Factors leading to the discard of deceased donor kidneys in the United States. Kidney Int. 2018 Jul;94(1):187-198. doi: 10.1016/j.kint.2018.02.016.
    PubMed link
  • Sachs DH. Transplantation tolerance through mixed chimerism: From allo to xeno. Xenotransplantation. 2018 May;25(3):e12420. doi: 10.1111/xen.12420.
    Journal link | PubMed link
  • Samstein B, Griesemer A, Halazun K, Kato T, Guarrera JV, Cherqui D, Emond JC. Pure Laparoscopic Donor Hepatectomies: Ready for Widespread Adoption? Ann Surg. 2018 Aug 10. doi: 10.1097/SLA.0000000000002959.
    Journal link | PubMed link

August 2018

  • Connors TJ, Baird JS, Yopes MC, Zens KD, Pethe K, Ravindranath TM, Ho SH, Farber DL. Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection. J Immunol. 2018 Jul 15;201(2):432-439.
    Journal link | PubMed link
  • Elnaggar AS, Griesemer AD, Bentley-Hibbert S, Brown RS Jr, Martinez M, Lobritto SJ, Kato T, Emond JC. Liver atrophy and regeneration in noncirrhotic portal vein thrombosis: Effect of surgical shunts. Liver Transpl. 2018 Jan 29. doi: 10.1002/lt.25024.
    Journal link | PubMed link
  • Przybyszewski EM, Verna EC, Lobritto SJ, Martinez M, Vittorio JM, Fox AN, Samstein B, Kato T, Griesemer AD, Emond JC. Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation in Children. Transplantation. 2018 Jun;102(6):953-960. doi: 10.1097/TP.0000000000002110.
    Journal link | PubMed link
  • Quillin RC 3rd, Bongu A, Kasper V, Vittorio JM, Martinez M, Lobritto SJ, Griesemer AD, Guarrera JV. Roux-en-Y enterolith leading to obstruction and ischemic necrosis after pediatric orthotopic liver transplantation. Pediatr Transplant. 2018 May;22(3):e13160. doi: 10.1111/petr.13160.
    Journal link | PubMed link
  • Rosenfeld AM, Meng W, Chen DY, Zhang B, Granot T, Farber DL, Hershberg U, Luning Prak ET. Computational Evaluation of B-Cell Clone Sizes in Bulk Populations. Front Immunol. 2018 Jun 29;9:1472. doi: 10.3389/fimmu.2018.01472. eCollection 2018.
    Journal link | PubMed link

June 2018

  • American Society of Transplant Surgeons Executive Committee, Gaber O, Reed A, Pruett T, Emond J. Transplantation in value-based care for patients with renal failure. Am J Transplant. 2018 Apr 20. doi: 10.1111/ajt.14878.
    Journal link | PubMed link
  • Batal I, Mohan S, De Serres SA, Vasilescu ER, Tsapepas D, Crew RJ, Patel SS, Serban G, McCune K, Husain SA, Chang JH, Herter JM, Bhagat G, Markowitz GS, D'Agati VD, Hardy MA, Ratner L, Chandraker A. Analysis of dendritic cells and ischemia-reperfusion changes in postimplantation renal allograft biopsies may serve as predictors of subsequent rejection episodes. Kidney Int. 2018 May;93(5):1227-1239.
    Journal link | PubMed link
  • Fishman JA, Sachs DH, Yamada K, Wilkinson RA. Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo. Xenotransplantation. 2018 Apr 6:e12395. doi: 10.1111/xen.12395. [Epub ahead of print]
    Journal link | PubMed link
  • Halazun KJ, Emond JC. Re: The Pursuit of Happiness. The thin line between rights and duties. Am J Transplant. 2018 Apr 28. doi: 10.1111/ajt.14899.
    Journal link | PubMed link
  • Michel SG, Madariaga MLL, LaMuraglia GM 2nd, Villani V, Sekijima M, Farkash EA, Colvin RB, Sachs DH, Yamada K, Rosengard BR, Allan JS, Madsen JC. The effects of brain death and ischemia on tolerance induction are organ-specific. Am J Transplant. 2018 May;18(5):1262-1269. doi: 10.1111/ajt.14674. Epub 2018 Mar 5.
    Journal link | PubMed link
  • Rivard CJ, Tanabe T, Lanaspa MA, Watanabe H, Nomura S, Andres-Hernando A, Garth K, Sekijima M, Ishimoto T, Ariyoshi Y, Garcia GE, Shah J, Boyd L, Tasaki M, Pomposelli T, Shimizu A, Sachs DH, Johnson RJ, Yamada K. Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to baboon xeno renal transplantation- an experimental study. Transpl Int. 2018 May 2. doi: 10.1111/tri.13273
    Journal link | PubMed link
  • Rosen SJ, Harris PE, Hardy MA. State of the Art: Role of the Dendritic Cell in Induction of Allograft Tolerance. Transplantation. 2018 Apr 19. doi: 10.1097/TP.0000000000002239.
    Journal link | PubMed link
  • Samstein B, de Melo-Martin I, Kapur S, Ratner L, Emond J. A liver for a kidney: Ethics of trans-organ paired exchange. Am J Transplant. 2018 May;18(5):1077-1082. doi: 10.1111/ajt.14690. Epub 2018 Mar 25.
    Journal link | PubMed link
  • Shah JA, Lanaspa MA, Tanabe T, Watanabe H, Johnson RJ, Yamada K. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. J Immunol Res. 2018 Mar 4;2018:6413012. doi: 10.1155/2018/6413012. eCollection 2018. Review.
    Journal link | PubMed link
  • Sondermeijer H, Witkowski P, Seki T, van der Laarse A, Itescu S, Hardy MA. RGDfK-peptide modified alginate scaffold for cell transplantation and cardiac neovascularization. Tissue Eng. Part A. 2017 Sep 22. doi: 10.1089/ten.TEA.2017.0221. [Epub ahead of print]
    Journal link | PubMed link
  • Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation. Cell Transplant. 2017 Nov;26(11):1755-1762. doi: 10.1177/0963689717732993.
    Journal link | PubMed link

May 2018

  • Shah JA, Lanaspa MA, Tanabe T, Watanabe H, Johnson RJ, Yamada K. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. J Immunol Res. 2018 Mar 4;2018:6413012. doi: 10.1155/2018/6413012. eCollection 2018.
    Journal linkPubMed Link
  • Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake-Alper DK, Boyd LK, Louras NJ, Asfour A, Danton MA, Ho SH, Arn JS, Hawley RJ, Shimizu A, Nagayasu T, Ayares D, Lorber MI, Sykes M, Sachs DH and Yamada K GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels. Xenotransplantation. 2018 Mar 12. doi: 10.1111/xen.12391.
    Journal link | PubMed Link

March 2018

  • Baker TB, Zimmerman MA, Goodrich NP, Samstein B, Pomfret EA, Pomposelli JJ, Gillespie BW, Berg CL, Emond JC, Merion RM. Biliary reconstructive techniques and associated anatomic variants in adult living donor liver transplantations: The adult-to-adult living donor liver transplantation cohort study experience. Liver Transpl. 2017 Dec;23(12):1519-1530. doi: 10.1002/lt.24872.
    Journal link | PubMed link
  • Chaudhry SG, Bentley-Hibbert S, Stern J, Lobritto S, Martinez M, Vittorio J, Halazun KJ, Lee HT, Emond J, Kato T, Samstein B, Griesemer A. Growth of liver allografts over time in pediatric transplant recipients. Pediatr Transplant. 2018 Mar;22(2). doi: 10.1111/petr.13104.
    Journal link | PubMed link
  • Elnaggar AS, Griesemer AD, Bentley-Hibbert S, Brown RS Jr, Martinez M, Lobritto SJ, Kato T, Emond JC. Liver Atrophy and Regeneration in Non-Cirrhotic Portal Vein Thrombosis: Effect of Surgical Shunts. Liver Transpl. 2018 Jan 29. doi: 10.1002/lt.25024.
    Journal link | PubMed link
  • Halazun KJ, Rana AA, Fortune B, Quillin RC 3rd, Verna EC, Samstein B, Guarrera JV, Kato T, Griesemer AD, Fox A, Brown RS Jr, Emond JC. No country for old livers? Examining and optimizing the utilization of elderly liver grafts. Am J Transplant. 2018 Mar;18(3):669-678. doi: 10.1111/ajt.14518. Epub 2017 Nov 8.
    Journal link | PubMed link
  • Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S. Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors. Clin J Am Soc Nephrol. 2018 Jan 6;13(1):118-127. doi: 10.2215/CJN.06550617.
    Journal link | PubMed link
  • Kumar BV, Connors TJ, Farber DL. Human T Cell Development, Localization, and Function throughout Life. Immunity. 2018 Feb 20;48(2):202-213. doi: 10.1016/j.immuni.2018.01.007.
    Journal link | PubMed link
  • Najjar M, Agrawal S, Emond JC, Halazun KJ. Pretreatment neutrophil-lymphocyte ratio: useful prognostic biomarker in hepatocellular carcinoma. J Hepatocell Carcinoma. 2018 Jan 18;5:17-28. doi: 10.2147/JHC.S86792. eCollection 2018. Review.
    Journal link | PubMed link
  • Orandi BJ, Luo X, King EA, Garonzik-Wang JM, Bae S, Montgomery RA, Stegall MD, Jordan SC, Oberholzer J, Dunn TB, Ratner LE, Kapur S, Pelletier RP, Roberts JP, Melcher ML, Singh P, Sudan DL, Posner MP, El-Amm JM, Shapiro R, Cooper M, Lipkowitz GS, Rees MA, Marsh CL, Sankari BR, Gerber DA, Nelson PW, Wellen J, Bozorgzadeh A, Osama Gaber A, Segev DL. Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study. Am J Transplant. 2018 Mar;18(3):650-658. doi: 10.1111/ajt.14472.
    Journal link | PubMed link
  • Przybyszewski EM, Verna EC, Lobritto SJ, Martinez M, Vittorio JM, Fox AN, Samstein B, Kato T, Griesemer AD, Emond JC. Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation in Children. Transplantation. 2018 Jan 23. doi: 10.1097/TP.0000000000002110. [Epub ahead of print]
    Journal link | PubMed link
  • Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. The neonatal window of opportunity-early priming for life. J Allergy Clin Immunol. 2017 Dec 14. pii: S0091-6749(17)31895-X. doi: 10.1016/j.jaci.2017.11.019.
    Journal link | PubMed link
  • Samstein B, de Melo-Martin I, Kapur S, Ratner L, Emond J. A Liver for a kidney: Ethics of trans-organ paired exchange. Am J Transplant. 2018 Feb 14. doi: 10.1111/ajt.14690.
    Journal link | PubMed link
  • Schold JD, Andreoni KA, Chandraker AK, Gaston RS, Locke JE, Mathur AK, Pruett TL, Rana A, Ratner LE, Buccini LD. Expanding clarity or confusion? Volatility of the 5-tier ratings assessing quality of transplant centers in the United States. Am J Transplant. 2018 Jan 9. doi: 10.1111/ajt.14659. [Epub ahead of print]
    Journal link | PubMed link
  • Turner DL, Goldklang M, Cvetkovski F, Paik D, Trischler J, Barahona J, Cao M, Dave R, Tanna N, D'Armiento JM, Farber DL. Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma. J Immunol. 2018 Mar 1;200(5):1561-1569. doi: 10.4049/jimmunol.1700257. Epub 2018 Jan 17.
    Journal link | PubMed link

February 2018

  • Sahara H, Sekijima M, Ariyoshi Y, Kawai A, Miura K, Waki S, Nathan L, Tomita Y, Iwanaga T, Nakano K, Matsunari H, Date H, Nagashima H, Shimizu A, Yamada K. Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys. Xenotransplantation. 2017 Oct 25. doi: 10.1111/xen.12359. [Epub ahead of print]
    Journal link | PubMed link
  • Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation. Cell Transplant. 2017 Nov;26(11):1755-1762. doi: 10.1177/0963689717732993.
    Journal link | PubMed link
  • Yamada K, Shah JA, Tanabe T, Lanaspa MA, Johnson RJ. Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Curr Transplant Rep. 2017 Jun;4(2):101-109.
    Journal link | PubMed link

January 2018

  • Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN 3rd, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR. Miscellaneous. Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12365. Epub 2017 Nov 28.
    Journal link | PubMed link
  • Rahnemai-Azar AA, Griesemer AD, Velasco ML, Kato T. Ex vivo excision of retroperitoneal soft tissue tumors: A case report. Oncol Lett. 2017 Oct;14(4):4863-4865.
    PubMed link | Journal link
  • Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. The neonatal window of opportunity — early priming for life. J Allergy Clin Immunol. 2017 Dec 13. pii: S0091-6749(17)31895-X. doi: 10.1016/j.jaci.2017.11.019. [Epub ahead of print]
    Journal link | PubMed link

December 2017

  • Borsotti C, Danzl NM, Nauman G, Hölzl MA, French C, Chavez E, Khosravi-Mararlooei M, Glauzy S, Delmotte FR, Meffre E, Savage DG, Campbell SR, Goland R, Greenberg E, Bi J, Satwani P, Yang S, Bathon J, Winchester R, Sykes M. HSC-extrinsic sex-related and intrinsic autoimmune disease-related human B cell variation is recapitulated in humanized mice. Blood Advances 2017 1:2007-2018;
    Journal link
  • Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6.
    Journal link | PubMed link
  • Kumar BV, Ma W, Miron M, Granot T, Guyer RS, Carpenter DJ, Senda T, Sun X, Ho SH, Lerner H, Friedman AL, Shen Y, Farber DL. Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.
    Cell Rep. 2017 Sep 19;20(12):2921-2934. doi: 10.1016/j.celrep.2017.08.078.
    Journal link | PubMed link
  • Meng W, Zhang B, Schwartz GW, Rosenfeld AM, Ren D, Thome JJC, Carpenter DJ, Matsuoka N, Lerner H, Friedman AL, Granot T, Farber DL, Shlomchik MJ, Hershberg U, Luning Prak ET. An atlas of B-cell clonal distribution in the human body. Nat Biotechnol. 2017 Sep;35(9):879-884. doi: 10.1038/nbt.3942. Epub 2017 Aug 21.
    Journal link | PubMed link
  • Zens KD, Chen JK, Guyer RS, Wu FL, Cvetkovski F, Miron M, Farber DL. Reduced generation of lung tissue-resident memory T cells during infancy. J Exp Med. 2017 Oct 2;214(10):2915-2932. doi: 10.1084/jem.20170521. Epub 2017 Aug 30.
    Journal link | PubMed link
  • Zens KD, Connors T, Farber DL. Tissue compartmentalization of T cell responses during early life. Semin Immunopathol. 2017 Sep 11. doi: 10.1007/s00281-017-0648-7. [Epub ahead of print] Review.
    Journal link | PubMed link

November 2017

  • DeWolf S, Sykes M. Alloimmune T cells in transplantation. J Clin Invest. 2017 Jun 30;127(7):2473-2481. doi: 10.1172/JCI90595. Epub 2017 Jun 19.
    Journal link | PubMed Link
  • Sondermeijer H, Witkowski P, Seki T, van der Laarse A, Itescu S, Hardy MA.
    RGDfK-peptide modified alginate scaffold for cell transplantation and cardiac neovascularization. Tissue Eng Part A. 2017 Sep 22. doi: 10.1089/ten.TEA.2017.0221
    Journal link | PubMed Link
  • Zuber J, Sykes M. Mechanisms of Mixed Chimerism-Based Transplant Tolerance. Trends Immunol. 2017 Aug 18. pii: S1471-4906(17)30146-1. doi: 10.1016/j.it.2017.07.008. [Epub ahead of print]
    Journal link | PubMed Link

October 2017

  • Sahara H, Watanabe H, Pomposelli T, Yamada K. Lung xenotransplantation. Curr Opin Organ Transplant. 2017 Sep 1. doi: 10.1097/MOT.0000000000000465. [Epub ahead of print]
    Journal link | PubMed link
  • Sekijima M, Sahara H, Miki K, Villani V, Ariyoshi Y, Iwanaga T, Tomita Y, Yamada K. Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine. Journal of Surgical Research, Vol 219, November 2017, Pages 165-172.
    Journal link
  • Yamada K, Sykes M, Sachs DH. Tolerance in xenotransplantation. Curr Opin Organ Transplant. 2017 Sep 20. doi: 10.1097/MOT.0000000000000466. [Epub ahead of print]
    Journal link | PubMed link

September 2017

  • Carpenter, D.J., Matsuoka, N., Granot, T., Kumar, B.V., Senda, T., Thome, J.J.C., Gordon, C.L., Miron, M., Weiner, J., Lerner, H., Friedman, A., Griesemer, A.D., Farber, D.L. (2017) Human immunology studies using organ donors: impact of clinical variations on immune parameters in tissues and circulation. Am. J. Trans. doi: 10.1111/ajt.14434. [Epub ahead of print]. NB: A surgery resident is first author/startup grant and award recipient
    Journal link | PubMed link
  • Granot, T., Senda, T., Carpenter, D., Matsuoka, N., Weiner, J., Gordon, C.L., Miron, M., Kumar, B.V., Griesemer, A., Ho, S-H, Lerner, H., Thome, J.J.C., Connors, T., Reizis, B., and Farber, D.L. (2017) Dendritic cells display subset and tissue-specific maturation dynamics over human life. Immunity, 46:504-515.
    Journal link | PubMed link
  • Gordon, C.L., Miron, M., Thome, J.J.C., Matsuoka, N., Weiner, J., Rak, M., Igarashi, S., Granot, T., Lerner, H., Goodrum, F. and Farber, D.L. (2017) Tissue-reservoirs of T cell immunity in persistent human CMV infection. J. Exp. Med. 214:651-667.
    Journal link | PubMed link
  • Snyder, M.E. and Farber, D.L. (2017) Thymic-peripheral crosstalk in lymphoodepletion therapy. Am. J. Trans. 17:1970-1971.
    Journal link | PubMed link

July 2017

  • Shah JA, Tanabe T, Yamada K. Role of Intrinsic Factors in the Growth of Transplanted Organs Following Transplantation J Immuno Biol 2017, 2 (2): 122.1-14.
    Journal link | PubMed link
  • Shah JA, Patel MS, Elias N, Navarro-Alvarez N, Rosales I, Wilkinson RA, Louras NJ, Hertl M, Fishman JA, Colvin RB, Cosimi AB, Markmann JF, Sachs DH, Vagefi PA. Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade. Am J Transplant. 2017 May 10. doi: 10.1111/ajt.14341. [Epub ahead of print]
    Journal link | PubMed link
  • Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K. Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation. Am J Transplant. 2017 Jan 24. doi: 10.1111/ajt.14210. [Epub ahead of print]
    Journal link | PubMed link
  • Yamada K, ShahJA, Tanabe T, Lanaspa MA, Johnson RJ Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Current Transplantation Reports. 2017 June: 4 (2): 101-109.
    Journal link

Book Chapter

  • Kazuhiko Yamada*, Masayuki Tasaki, Adam Griesemer and Jigesh Shah, Kidney Transplantation, Bioengineering, and Regeneration 1st Edition -Kidney Transplantation in the Regenerative Medicine Era Chapter 84: Xenotransplantation and Kidney Regenerative technology Eds: Giuseppe Orlando, Giuseppe Remuzzi, David Williams. Publisher: AP – Elsevier. eBook ISBN: 9780128018361, Hardcover ISBN: 9780128017340.

April 2017

  • Duran-Struuck R, Buhler L, Alonso-Guallart P, Zitsman J, Kato Y, Wu A, McMurchy A, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi A, Wuu C, Slate A, Mapara M, Baker S, Tokarz R, D’Agati V, Hammer S, Pereira M, Lipkin W, Wekerle T, Levings M, Sykes M. Effect of ex vivo expanded recipient regulatory T cells on hematopoietic chimerism and kidney allograft tolerance across MHC barriers in cynomolgus macaques. Transplantation. 2017 Feb;101(2):274-283 2016.
    Journal link
  • Halazun KJ, Najjar M, Abdelmessih RM, Samstein B, Griesemer AD, Guarrera JV,Kato T, Verna EC, Emond JC, Brown RS Jr. Recurrence After Liver Transplantationfor Hepatocellular Carcinoma: A New MORAL to the Story. Ann Surg. 2017
    Mar;265(3):557-564.
    Journal link
  • Pathiraja V, Villani V, Tasaki M, Matar AJ, Duran-Struuck R, Yamada R, Moran SG, Clayman ES, Hanekamp J, Shimizu A, Sachs DH, Huang CA, Yamada K. Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys. Am J Transplant. 2017
    Jan;17(1):91-102.
    Journal link | Pubmed link
  • Salerno DM, Tsapepas D, Papachristos A, Chang JH, Martin S, Hardy MA, McKeen J. Direct oral anticoagulant considerations in solid organ transplantation: A review. Clinical transplantation. 2017 January;31(1).
    Journal link | Pubmed link
  • Sprangers B, DeWolf S, Savage TM, Morokata T, Obradovic A, LoCascio SA, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer FI, Olek S, Dombkowski DM, Turka LA, Colvin R, Winchester R, Kawai T, Sykes M. Origin of
    enriched regulatory t cells in patients receiving combined kidney/bone marrow transplantation to induce transplantation tolerance. American Journal of Transplantation. 2017 Mar. 1, doi: 10.1111/ajt.14251. [Epub ahead of print]
    Journal link | Pubmed link
  • Weiner J, Zuber J, Shonts B, Yang S, Fu J, Martinez M, Farber D, Kato T, Sykes M. Long-term persistence of innate lymphoid cells in the gut after intestinal transplantation. Transplantation. 2016 Dec 8, DOI: 10.1097/TP.0000000000001593.
    [Epub ahead of print] PMC journal.
    Journal link

February 2017

  • DiMartini A, Dew MA, Liu Q, Simpson MA, Ladner DP, Smith AR, Zee J, Abbey S, Gillespie BW, Weinrieb R, Mandell MS, Fisher RA, Emond JC, Freise CE, Sherker AH, Butt Z. Social and Financial Outcomes of Living Liver Donation: A Prospective Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2). Am J Transplant. 2016 Sep 20. doi: 10.1111/ajt.14055. [Epub ahead of print]
    Journal link | Pubmed link
  • Eliaz I, Patil A, Navarro-Alvarez N, Wang Z, Eliaz A, Weil E, Wilk B, Sachs DH, Huang CA. Methods for the detection and serum depletion of porcine galectin-3. J Clin Apher. 2017 Jan 13. doi: 10.1002/jca.21521. [Epub ahead of print]
    Journal link | Pubmed link
  • Emond JC. Laparoscopic donor hepatectomy: a way forward? Transplantation. 2016 Nov 15. [Epub ahead of print] No abstract available.
    Journal link | Pubmed link
  • Emond JC, Griesemer AD. Tolerance in clinical liver transplantation: The long road ahead. Hepatology. 2017 Feb;65(2):411-413. doi: 10.1002/hep.28862.
    Journal link | Pubmed link
  • Furr A, Hardy MA, Barret JP, Barker JH. Surgical, ethical, and psychosocial considerations in head transplantation. Int J Surg. 2017 Jan 18. pii: S1743-9191(17)30080-8.
    Journal link | Pubmed link
  • Hardy MA, Furr A, Barret JP, Barker JH. The immunologic considerations in head transplantation. Int J Surg. 2017 Jan 24. pii: S1743-9191(17)30088-2.
    Journal link | Pubmed link
  • Shanmugarajah K, Powell H, Leonard DA, Mallard C, Albritton A, Harrington E, Randolph MA, Farkash E, Sachs DH, Kurtz JM, Cetrulo CL Jr. The Effect of MHC Antigen Matching Between Donors and Recipients on Skin Tolerance of Vascularized Composite Allografts. Am J Transplant. 2016 Dec 30. doi: 10.1111/ajt.14189. [Epub ahead of print]
    Journal link | Pubmed link
  • Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K. Role of intrinsic (graft) vs. extrinsic (host) factors in the growth of transplanted organs following allogeneic and xenogeneic transplantation. Am J Transplant. 2017 Jan 24. doi: 10.1111/ajt.14210. [Epub ahead of print]
    Journal link | Pubmed link

December 2016

  • Ali ZA, Karimi Galougahi K, Nazif T, Maehara A, Hardy MA, Cohen DJ, Ratner LE, Collins MB, Moses JW, Kirtane AJ, Stone GW, Karmpaliotis D, Leon MB. Imaging- and physiology-guided percutaneous coronary intervention without contrast administration in advanced renal failure: a feasibility, safety, and outcome study. Eur Heart J. 2016 Oct 21;37(40):3090-3095.
    Journal link | Pubmed link
  • Duran-Struuck R, Sondermeijer HP, Bühler L, Alonso-Guallart P, Zitsman J, Kato Y, Wu A, McMurchy AN, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi AB, Wuu CS, Slate A, Mapara M, Baker S, Tokarz R, D, Agati V, Hammer S, Pereira M, Lipkin WI, Wekerle T, Levings M, Sykes M. Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques. Transplantation. 2016 Nov 15. PMID: 27846155.
    Journal link | Pubmed link
  • Duran-Struuck R, Matar AJ, Crepeau RL, Teague AG, Horner BM, Pathiraja V, Spitzer TR, Fishman JA, Bronson RT, Sachs DH, Huang CA. Donor Lymphocyte InfusionMediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 Nov;22(11):1953-1960.
    Journal link | Pubmed link
  • Halazun KJ, Najjar M, Abdelmessih RM, Samstein B, Griesemer AD, Guarrera JV, Kato T, Verna EC, Emond JC, Brown RS Jr. Recurrence After Liver Transplantation for Hepatocellular Carcinoma: A New MORAL to the Story. Ann Surg. 2016 Sep 16. PMID: 27611615.
    Journal link | Pubmed link
  • Mandell MS, Smith AR, Dew MA, Gordon DB, Holtzman S, Howell T, DiMartini AF, Butt Z, Simpson MA, Ladner DP, Freise CE, McCluskey SA, Fisher RA, Guarrera JV, Olthoff KM, Pomfret EA. Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study.Transplantation. 2016 Nov;100(11):2362-2371.
    Journal link | Pubmed link
  • Quillin RC 3rd, Guarrera JV. "In 10 years" of debate: Pro-machine perfusion for liver preservation will be universal.Liver Transpl. 2016 Nov;22(S1):25-28.
    Journal link | Pubmed link
  • Salerno DM, Tsapepas D, Papachristos A, Chang JH, Martin S, Hardy MA, McKeen J. Direct oral anticoagulant considerations in solid organ transplantation: a review. Clin Transplant. 2016 Nov 16. doi: 10.1111/ctr.12873. [Epub ahead of print] Review.
    Journal link | Pubmed link

November 2016

  • Emond JC, Griesemer AD. Tolerance in clinical liver transplantation: The long road ahead. Hepatology. 2016 Oct 7.
    Journal link | Pubmed link
  • Zuber J, Shonts B, Lau S, Obradovic A, Fu J, Yang S, Lambert M, Coley S, Weiner J, Thome J, DeWolf S, Farber DL, Shen Y, Caillat-Zucman S, Bhagat G, Griesemer A, Martinez M, Kato T, Sykes M. Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome. Science Immunology. 2016 October 07; 1(4)
    Journal link