Physician’s Profile

Isaac George, MD

Surgical Director of the Heart Valve Center at Columbia
Director Hybrid Coronary Interventions, New York, NY
Affiliations: 
NewYork-Presbyterian/Columbia
Board Certificates: 
Cardiothoracic Surgery
Surgery
Expertise: 
Aortic Dissection
Aortic Disease
Aortic Aneurysm With Dissection
Aortic Surgery
Aortic Stent Grafts
Aortic Stenosis
Heart Valve Surgery
Robotic Surgery
Aortic and Mitral Valve Surgery
Mitral Valve Reconstruction
Aortic Aneurysm
Valve Replacement
Aortic Arch Surgery
High Risk Surgery of the Elderly
Heart Disease
Mitral Valve Replacement/Repair
Heart Disease and Women
Heart Surgery
Valvular Heart Disease
Heart Valve Replacement
Heart Valve Disease
Coronary Artery and Valvular Disease
Heart Transplantation
Minimally Invasive Aneurysm Repair
TAVR (Transcatheter Aortic Valve Replacement)
Marfan's Syndrome
Heart Failure
Aortic Aneurysm Repair
Heart Valve Repair
Mitral/Aortic Valve Replacement
Coronary Artery Bypass Surgery (Off Pump)
Valve Reconstruction/Repair
Percutaneous Valve Interventions
Aortic Valve Surgery
Aortic Aneurysm Surgery
Minimally Invasive Heart Surgery
Bloodless Surgery
Minimally Invasive Valve Repair
Thoracic Aneurysm Repair
Open Heart Surgery
Mitral Valve Repair
Pericardial Disease
Off Pump Coronary Bypass Surgery
Mitral Valve Surgery
Atrial Fibrillation, Surgical Treatment
Honors: 

1993 – Duke University Comprehensive Cancer Center Fellowship

1995 – Pi Tau Sigma, Mechanical Engineering Honor Society

2004 – New Era Cardiac Surgery Conference Scholarship

2006 – Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons

2007 Blakemore Award – Best Resident Research Award, Columbia University College of Physicians and Surgeons

2008 Blakemore Prize – Best Resident Research Award, Columbia University College of Physicians and Surgeons

Interests: 
Regulation of myostatin signaling in human cardiomyopathy
TGFB regulation in non-syndromic aortic aneurysm formation.
Valve interstitial cell activation mechanisms after surgical and transcatheter valve replacement.
Clinical outcomes after valve and hybrid surgery.
Cardiomyopathy
Aortic aneurysm formation
Surgical and transcatheter valve replacement
About: 

Dr. Isaac George, MD joined NewYork Presbyterian/Columbia University Medical Center in the Department of Surgery in July of 2001 as an resident in general surgery following his graduation from Duke University School of Medicine. Prior to receiving his MD, Dr. George completed a B.S. in Mechanical Engineering at Massachusetts Institute of Technology in 1997. Dr. George also completed a fellowship program in cardiothoracic surgery in 2011 as well as a fellowship program in interventional cardiology in 2012. In July, 2012 Dr. George became an Assistant Professor of Surgery.

Dr. George is board certified in thoracic surgery and general surgery. He performs all types of open complex adult cardiac surgery (aortic, mitral and tricuspid valve surgery, aortic aneurysm surgery, coronary bypass grafting, robotic surgery) and annually performs 200+ open heart surgeries a year. He is one of the few physicians in the world trained in both cardiac surgery and interventional cardiology, and is currently the Surgical Director of the Structural Heart and Valve Center at Columbia University Medical Center.

Dr. George is focused on integrating new technology and innovation into his clinical practice. He is trained in the most current and cutting-edge procedures including Transcatheter Aortic and Mitral Valve Replacement (TAVR, TMVR), transcatheter valvular repair, percutaneous coronary stenting, and aortic stent grafting. He performs over 500 transcatheter valve procedures a year, in addition to his busy open surgical practice and has personally done almost 2000 TAVR procedures. Because he is trained in multiple disciplines, he is able to combine strategies to create a personalized treatment for each individual patient. As Primary Investigator of a national TAVR trial and with involvement in numerous other clinical trials, he has extensive clinical research trial experience. 

Dr. George is involved in both benchtop and clinical research as well. His primary scientific goals involve the regulatory mechanisms of myostatin (a negative regulator of muscle growth) to insulin-like growth factor-1 and its role in cardiac hypertrophy and cardiomyopathy. Specifically, his group is the first to report the importance of myostatin activation in heart failure. As director of the cardiac surgery research laboratory, he oversees surgical fellows, post-doctoral students, masters students, and research assistants in both scientific projects and clinical outcomes in cardiac surgery and TAVR. His projects reflect the translational nature of the lab as well as his clinical interests. His clinical practice allows him to be uniquely positioned to advance this research with a clinical endpoint and potential therapeutic intervention as the goal.

Publications: 
Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George I, Takayama H, Naka Y, Goldberg IJ, Schulze PC.  Increased de novo ceramid synthesis and accumulation of ceramides in failing myocardium.  (submitted)
Castano A, Narotsky D, Morgenstern R, Hamid N, Khalique OK, Rubin J, Chiuzan C, Nazif T, Vahl T, George I, Kodali S, Leon MB, Hahn RT, Bokhari S, Maurer MS.  Unveiling Transthyretin Cardiac Amyloidosis and its Predictors Among Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
Zhang X, Ji R, Liao X, Castillero E, Kennel PJ, Brunjes D, Drosatos K, George I, Chen E, Schulze PC.  miR-195 Regulates Myocardial Metabolism in Heart Failure via Alterations in SIRT3 Expression and Mitochondrial Proteins Acetylation Profile.  (submitted)
Langer NB, Hamid NB, Nazif TM, Khalique O, Vahl TP, White J, Terre J, Hastings R, Leung D, Hahn RT, Leon MB, Kodali SK, George I.  Injuries to the Aorta, Aortic Annulus, and Left Ventricle During Transcathether Aortic Valve Replacement: Management and Outcomes.  (submitted)
Salna M, Nazif T, Khalique OK, Vahl T, Chiuzan C, White J, Hamid N, Hastings R, Terre J, Patel A, Wang C, Wu Y, Park JE, Kurlansky P, Bapat V, Borger M, Hahn RT, Leon MB, Smith CR, Kodali SK, George I.  Comparative Impact of Small Prosthesis Size on Patients undergoing Transcatheter or Surgical Aortic Valve Replacement.  (submitted)
Popma JJ, Reardon MJ, Khabbaz K, Harrison KJ, Hughes CG, Kodali SK, George I, Deeb M, Chetcuti S, Kipperman R, Brown J, Qiao H, Slater J, Williams MR.  Early Clinical Outcomes After Transcatheter Aortic Valve Replacement Using a Novel Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis Suboptimal for Surgery: Results of the Evolut R Study.  (submitted)
Hamid N, White J, Kodali SK, Nazif TM, Vahl T, Paradis JM, George I, Leon MB, Hahn RT.  Impact of Methodological Differences in 3-Dimensional Echocardiographic Measurements of the Aortic Annulus Compared to Computed Tomography Angiography Prior to Transcatheter Aortic Valve Replacement.  (submitted – J Am Soc Echocardiography)
Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AVB, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.  Lipocalin-2 deficiency attenuates pressure overload-induced heart failure in mice: a role of reduced HMGB1-induced TLR4 signaling and NLRP3 inflammasome activation. (submitted)
Castillero E, Ali Z, Akashi H, Wang C, Kheysin N, Park JE, Hegde S, Patel S, Stein S, Cuenca C, Leung D, Topkara V, Colombo P, Naka Y, Sweeney HL, Schultze PC, George I.  Structural and Functional Cardiac Profile after Prolonged Duration of Mechanical Unloading: Potential Implications for Myocardial Recovery. (submitted)
Coromilas E, Que-Xu E, Moore D, Kato T, Wu C, Ji R, Givens R, Jorde U, Takayama H, Naka Y, George I, Mancini D, Schulze PC.  Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantation.  (accepted-BMC Cardiovascular Disorders)
Hasting R, George I.  Sapien 3 Device in Current US TAVR Practice.  Cardiac Interventions Today.  (accepted)
Guerrero M, Dvir D, Himbert D, Urena M, Eleid M, Wang DD, Greenbaum A, Mahadevan VS, Holzhey D, O’Hair D, Dumonteil N, Rodes-Cabau J, Piazza N, Palma JH, DeLago A, Ferrari E, Witkowski A, Wendler O, Kornowski R, Martinez-Clark P, Ciaburri D, Shemin R, Alnasser S, McAllister D, Bena M, Kerendi F, Pavlides G, Sobrinhio JJ, Attizzani GF, George I, Nickenig G, Fass AA, Cribier A, Bapat V, Feldman T, Rihal C, Vahanian A, Webb J, O’Neill W.  Transcatheter Mitral Valve Replacement in Native Mitral Valve Calcific Stenosis with Severe Mitral Annular Calcification.  (Accepted-Jacc Cardiovasc Intervent)
Khalique OK, Hamid N, Kodali SK, Nazif TM, Vahl TP, Paradis JM, George I, Leon MB, Hahn RT.  Differences in 3-Dimensional Echocardiographic Measurements of the Aortic Annulus Prior to Transcatheter Aortic Valve Replacement and Impact on Optimal % Oversizing Cutoffs.  (submitted)
Guglielmetti L, Nazif T, Sorabella R, Akkoc D, Kantor A, Gomez A, Wang C, Takayama H, Dizon J, Borger M, George I.  Bicuspid Aortic Valve Increases Risk of Permanent Pacemaker Following Aortic Root Replacement.  (accepted-EJCTS)
Dadson K, Kovacevic V, Rengasamy P, Kim GH, Boo S, Li RK, George I, Schulze PC, Hinz B, Sweeney G.  Cellular, structural, and functional cardiac remodeling following pressure overload and unloading.  (accepted-Int J Cardiology)
Ota T, Yerebakan H, Neely RC, Mongero L, George I, Takayama H, Williams MR, Naka Y, Argenziano M, Bacha E, Smith CR, Stewart AS.  Short-term Outcomes in Adult Cardiac Surgery in Use of Del Nido Cardioplegia Solution.  Perfusion 2015 doi: 10.1177/0267659115599453.
Pulerwitz TC, Khalique OK, Nazif TN, Rozenshtein A, Pearson GDN, Vahl T, Kodali SK, George I, Leon MB, Hahn RT, D’Souza B, Po MJ, Einstein AJ.  Very Low Intravenous Contrast Volume Protocol for Computed Tomography Angiography Providing Comprehensive Cardiac and Vascular Assessment for Transcatheter Aortic Valve Replacement in Patients with Chronic Kidney Disease.  (submitted-JACC Int)
Sorabella R, Yerebakan H, Najjar M, Bader A, Gomez A, Schulze PC, Mancini D, Takayama H, Naka Y, George I.  The Use of Circulatory Arrest During Heart Transplantation Doe Not Worsen Post-Transplant Survival.  (accepted-Annals of Thor Surg)
Lee M, Akashi H, Kato TS, Takayama H, Wu C, Xu K, Collado E, Weber MP, Kennel PJ, Brunhes DL, Ji R, Naka Y, George I, Mancini D, Farr M, Schulze PC.  Vascular Inflammation and abnormal aortic histomorphometry in patients following pulsatile and continuous flow left ventricular assist device placement.  (accepted - J Heart Lung Transpl) 
Guglielmetti L, Sorabella R, Najjar M, Lambert D, Kim E, Kurlansky P, Borger M, Argenziano M, Smith CR, George I.  Bridging Anticoagulation after Aortic Mechanical Heart Valve Replacement-A Questionable Routine?  (accepted-Annals of Thor Surg)
Han SM, Sorabella R, Vasan V, Grbic M, Yerebakan H, Lambert D, Prasad R, Castillero E, Takayama H, Kurlansky P, Borger M, Gordon R, George I.  Influence of of Staphylococcus Aureus on Outcomes after Valvular Surgery for Infective Endocarditis.  (submitted)
Khalique OK, Pulerwitz TC, Kodali SK, Hahn T, Nazif TM, Vahl TP, George I, Leon MB, Pearson GD, Rozenshtein A, D’Souza B, Einstein AJ.  Optimizing Cardiac Computer Tomography Protocols for Comprehensive Acquisition Prior to Transcatheter Aortic Valve Replacement: A Practical How-To Guide.  (submitted-EHJ)
Sorabella R, Wu YS, Bader A, Smith CR, Takayama H,  Borger MA, George I.  Aortic Root Replacement in Octogenarians Offers Acceptable Perioperative and Late Outcomes.  Ann Thorac Surg 2015.  doi: 10.1016/j.athoracsur.2015.08.006.
Sorabella RA, Guglielmetti L, Kantor A, Takayama H, Schulze PC, Mancini D, Naka Y, George I.  Cardiac Donor Risk Factors Predictive of Short-Term Heart Transplant Recipient Mortality: An Analysis of the United Network of Organ Sharing Database.  (accepted-Transplantation Proceedings)
Lee M, Akashi H, Kato T, Takayama H, Wu C, Xu K, Collado J, Weber M, Kennel P, Brunjes D, Ji R, Naka Y, George I, Mancini D, Farr MJ, PC Schulze.  Vascular Inflammation and Abnormal Aortic Histomorphometry in Patients Following Pulsatile and Continuous Flow Ventricular Assist Device Placement. (submitted-Circ HF)
Tang GH, George I, Hahn RT, Bapat V, Szeto WY, Kodali S.  Transcatheter Mitral Valve Replacement (TMVR): Design Implications, Potential Pitfalls, and Outcome Assessment.  Cardiol Rev  2015;23(6):290-6.
Hahn RT, Fox B, Williams M, Khalique O, George I, Nazif T, Vahl T, Gada H, Hamid N, White J, Parikh P, Leon MB, Kodali SK.  Implantation Characteristics of the Edwards Sapien 3 Transcatheter Heart Valve: An Echocardiographic Study.  (submitted-JASE)
Zizola C, Kennel P, Akashi H, Ji R, Castillero E, George I, Homma S, Schulze PC.  Activation of PPAR delta signaling corrects impaired skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic cardiomyopathy.  Am J Heart Circ Physiol  2015.  doi: 10.1152/ajpheart.00679.2014.
Najjar M, Yerebakan H, Sorabella RA, Donovan D, Kossar AP, Sreekanth S, Kurlansky P, Borger MA, Argenziano M, George I.  Acute Kidney Injury Following Surgical Aortic Valve Replacement: Incidence, Predictors, and Outcomes.  Expert Rev Cardiovasc Ther  2015;13(3):301-16.
Sorabella RA, Han SM, Grbic M, Wu YS, Takayama H, Kurlansky P, Borger M, Argenziano M, Gordon R, George I.  Early Operation for Endocarditis Complicated by Preoperative Cerebral Emboli is Not Associated with Worsened Outcomes.  Ann Thorac Surg  2015;100(2):501-8.
Hamid N, Khalique O, Kodali SK, Monaghan MJ, Dvir D, Bapat V, Nazif T, Vahl T, George I, Leon MB, Hahn RT.  Transcatheter Valve Implantation in Failed Surgically Inserted Bioprosthesis.  JACC Cardiovasc Imag  2015;8:960-979.
Chai P, George I, Nazif T, Kalfa D, Kodali SK, Torres A, Vincent JA, Leon MB, Bacha EA.  Use of stented bovine pericardial valve for surgical mitral valve replacement in infants.  J Thorac Vasc Surg  2015.  doi: http://dx.doi.org/10.1016/j/jtcvs.2015.09.050.
Castillero E, Akashi H, Najjar M, Kennel P, Wang C, Sweeney HL, Schulze PC, George I.  Cardiac Myostatin Upregulation Occurs Immediately After Myocardial Ischemia and is Involved in Skeletal Muscle Activation of Atrophy.  Biochem Biophys Res Comm 2015;457(1):106-111.
George I, Najjar M, Akashi H, Nishimura T, Yerebakan H, Mongero L, Beck J, Vanderberg J, Takayama H, Williams M.  Continuous Retrograde Administration of Del Nido Cardioplegia: Feasibility and Safety in a Small Series.  J Cardiothorac Surg  2015;10:176-180.
Najjar M, Yerebakan H, Sorabella R, Guglielmetti L, Vandenberge J, Kurlansky P, Williams MR, Argenziano M, Smith CR, George I.  Reversibility of Chronic Kidney Disease and Outcomes Following Aortic Valve Replacement.  Interact Cardiovasc Thorac Surg 2015;21(4):499-505.
Marcoff L, Sun YP, Vahl, T, Bustami R, Kodali S, Williams M, Khalique O, Nazif T, Paradis JM, George I, Leon MB, Hahn RT.  Quantitative Assessment of the Sapien Transcatheter Valve Position, Operator-Independent Motion, and Coaxility by Transesophageal Echocardiography.   (submitted)
Santana O, Stone GW, Lamelas JL, Lamas G, Kurlansky P, George I, Kirtane AJ, Smith CR, Beohar N.  Outcomes of a Combined Approach to Percutaneous Coronary Revascularization and Cardiac Valve Surgery.  (submitted)
Sklepkiewicz P, Takayuki S, Rajbr K, Jie S, Kwon S, Mercer B, Bodine P, Schermuly RT, George I, Schulze PC, D’Armiento JM.  Loss of SFRP-1 Leads to Deterioriation of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy. Circ Heart Fail  2015;8(2):362-72.
Sorabella R, Mamuyac E, Yerebakan H, Najjar M, Choi V, Takayama H, Naka Y, Argenziano M, Smith CR, George I.  Residual Tricuspid Regurgitation Following Tricuspid Valve Repair During Concomitant Valve Surgery Worsens Late Survival.  Heart Surg Forum  2015.  doi: dx.doi.org/10.1532/hsf.1469.
Eudailey K, Yi S, Mongero L, Wagner G, Guarerra J, George I.  Trans-Diaphragmatic left ventricular venting during peripheral venous-arterial extracorporeal membrane oxygenation.  Perfusion  2015;30(8):701-3.
Khalique O, Hahn RT, Gada H, Nazif T, Vahl T, George I, Kalesan B, Williams MR, Leon MB, Kodali SK.  Quantity and Location of Aortic Valve Complex Calcification Predicts Severity and Location of Paravalvular Regurgitation and Frequency of Post-Dilatation After Balloon-Expandable Transcatheter Aortic Valve Replacement.  JACC Cardiovasc Interv  2014; 7(8):885-94.
Proschinske KB, Qiu S, Wu C, Kato TS, Khawaja T, Takayama H, Naka Y, Templeton D, George I, Farr MA, Mancini DM, Schulze PC.  Neutrophil gelatinase-associated lipocalin and cystatin C for the prediction of clinical events in pateints with advanced heart failure, after ventricular assist device placement, and following heart transplantation.  J Heart Lung Transplant 2014;33(12):1215-22.
Forster M, Khalique O, Williams MR, Kodali S, Nazif T, George I, Paradis JM, Grubb K, Marcoff L, Gada H, Vahl T, Leon MB, Hahn RT.  Use of Three Dimensional Transesophageal Echocardiograophic Measurements of the Aortic Annulus and Procedural Outcomes.  (submitted)
Paradis JM, Fried J, Nazif T, Kirtane A, Harjai K, Khalique O, Grubb K, George I, Hahn R, Williams M, Leon MB, Kodali S.  Aortic stenosis and coronary artery disease: What do we know? What don’t we know?  A comprehensive review of the literature with proposed treatment algorithms.  Eur Heart J  2014;31:2069-82.
Sorabella R, Akashi H, Yerebakan H, Najjar M, Mannan A, Williams MR, Smith CR, George I.  Myocardial Protection Using del Nido Cardioplegia Solution in Adult Reoperative Aortic Valve Surgery.  J Cardiac Surgery 2014;29(4): 445-9.
Yerebakan H, Sorabella R, Najjar M, Castillero E, Mongero L, Beck J, Hossain M, Takayama H, Williams MR, Naka Y, Argenziano M, Bacha E, Smith CR, George I.  Del Nido Cardioplegia Can be Safely Administered in High-Risk Coronary Artery Bypass Grafting Surgery After Acute Myocardial Infarction:  A Propensity Matched Comparison.  J Cardiothoracic Surg 2014;14:1746-9.
Ali ZA, Poludasu S, Qureshi YH, Krishnan P, Ali AA, Tatonetti N, Downey P, Zalewski A, Nazif T, George I, Mandava A, Baber U, Dangas G, Mehran R, Kini A, Sharma SK.  Impact of Major Bleeding on Long Term Mortality in Anemic versus Nonanemic Patients Undergoing Percutaneous Coronary Intervention using Bivalirudin.  Am J Cardiol 2014;113(9):1481-6.
Khawaja T, Chokshi A, Ji R, Kato T, Xu K, Zizola C, Wu C, Forman DE, Ota T, Takayama H, Naka Y, George I, Mancini D, Schulze PC.  Ventricular Assist Device Implantation Improves Skeletal Muscle Function, Oxidative Capacity and Growth Hormone/Insulin-like Growth Factor-1 Axis Signaling in Patients with Advanced Heart Failure.  Cachexia, Sarcopenia, and Muscle 2014;5(4):297-305.
George I, Nazif T, Kalesan B, Kriegel J, Yerebakan H, Kirtane A, Kodali S, Williams M.  Feasibility and Safety of Single-Stage Hybrid Coronary Intervention and Valvular Cardiac Surgery.  Ann Thorac Surg 2015;99(6):2032-7.
Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D’Armiento JM, Ali Z, Schulze PC, George I.  Attenuation of the Unfolded Protein Response and Endoplasmic Reticulum Stress after Mechanical Unloading in Dilated Cardiomyopathy.  AJP Heart, Circ Phys 2015;309(3):H459-70.
George I, Yerebakan H, Kalesan B, Nazif T, Kodali S, Smith CR, Williams MR.  Age Alone Should Not Preclude Surgery: Contemporary Outcomes after Aortic Valve Replacement in Nonagenarians.  J Thorac Cardiovasc Surg 2014;148(4):1360-1369.
Ali A, Downey P, Singh G, Qi W, George I, Takayama H, Kirtane A, Krishnan P, Zalewski A, Freed D, Large SR, Ashley EA, Leon MB, Bacchetta M, Ali ZA.  Rat Model of Veno-Arterial Extracorporeal Membrane Oxygenation.  J Translat Med 2014;12:37.
Yang KC, Yamada KA, Patel AY, Topkara V, George I, Cheema FH, Ewald GA, Mann DL, Nerbonne JM.  Deep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNA in Failing Human and Remodeling with Mechanical Circulatory Support.   Circulation  2014;129(9):1009-21.
Dewey T, Bowers B, Thourani VH, Babaliaros V, Smith CR, Leon MB, Svensson LG, Tuczu M, Miller C, Teirstein P, Tyner J, Brown D, Fontana G, Makkar RR, Williams MR, George I, Kirtane AJ, Bavaria JE, Mack MJ.  Transapical Aortic Valve Replacement for Critical Aortic Stenosis – Results From the Non-Randomized Continued Access Cohort of the Partner Trial.  Annals of Thoracic Surgery 2013;96:2083-9.
Khalique O, Kodali S, Paradis JM, Nazif T, Williams MR, Einstein AJ, Pearson GD, Harjai K, Grubb K, George I, Leon MB, Hahn RT.  Annular Sizing Using a Novel 3-Dimensional Echocardiography Method:  Utility and Comparison to Cardiac Computer Tomography.  Circulation: Cardiovasc Imag 2014;7(1):155-63.
Khalique O, Hamid NB, Kodali SK, Nazif T, Marcoff L, Paradis JM, Williams MR, Vahl TP, George I, Leon MB, Hahn RT.  Improving the Accuracy of Effective Orifice Area Assessment After Transcatheter Aortic Valve Replacement: Validation of Left Ventricular Outflow Tract Diameter and Pulsed-wave Doppler Location and Impact of Three-Dimensional Measurements.  Am Soc Echocardiography 2015;S0894-7317.
George I, Kriegel J, Kalesan B, Paradis JM, Khalique O, Hahn RT, Leon MB, Kodali S, Williams MR.  Transthoracic Access for Transcatheter Aortic Valve Replacement: Technique and Experience using the Edwards Sapien Retroflex Delivery System.  Annals Thorac Surg 2014;98(1):347-9.
Ali ZA, Rinze R, Douglas G, Hu Y, Xiao Q, Qi W, McNeill E, Bursill C, George I, Greaves DR, Xu Q, Channon KM.  Endothelial GTP Cyclohydrolase I and Tetrahydrobiopterin  (BH4) Determine Vascular Remodeling through Enhanced Endothelial Cell Survival and Regeneration.  Circulation 2013;128:S50-8.
Grubb KJ, Nazif TM, Williams MR, George I.  Concurrent Coronary Artery and Valvular Heart Disease - Hybrid Treatment Strategies in 2013.  Interventional Cardiology Review 2013;8(2):127-30.
Paradis JM, Nazif T, George I, Leon M, Kodali S, Williams M.  Evolution of definitions and understanding of vascular complications related transcatheter Aortic Valve Replacement and Vascular Complication Definitions.   Minverva Cardioangiologica 2013;61:513-28.
George I, Shrikhande G, Williams MR. Stent Exteriorization Facilitates Use as an Alternative Arterial Bypass Conduit.  Catheter Cardiovasc Interv 2013; 82(3):E257-61.
Hahn R, Koss E, Khalique O, Williams MR, Paradis JM, Denault B, Kirtane AJ, George I, Leon MB, Kodali S.  Predicting Paravalvular Regurgitation Following Transcatheter Valve Replacement: Utility of Three-Dimensional Echocardiography Measurements of the Aortic Annulus.  J Am Soc Echocard  2013;26:1043-52.
Denault B, Koss E, Hahn R, Kodali S, Williams MR, Genereux P, Paradis JM, George I, Reiss GR, Moses JW, Smith CR, Leon MB.  Efficacy and Safety of Post-Dilatation to Reduce Para-Valvular Regurgitation During Balloon-Expandable Transcatheter Aortic Valve Replacement.  Circ Cardiovasc Interv  2013;6:85-91.
Zhang X, Ding N, Wang H, Augostini R, Yang B, Xu D, Ju W, Hou X, Li X, Ni B, Cao K, George I, Wang J, Zhang S.  Transvenous Phrenic Nerve Stimulation in Patients with Cheyne-Stokes Respiration and Congestive Heart Failure: A Safety and Proof-of-Concept Study.  Chest  2012;142:927-34.
George I, Bish LT, Maybaum S, Naka Y, Chen J, Sweeney HL.  Myostatin Regulation in Pediatric Cardiomyopathy.  PLoS One  2011;10.1371/journal.pone.0023818.
George I, Xu K, Wang N, Wang J.  β-Adrenergic Receptor Blockade Reduces Endoplasmic Reticulum Stress and Normalizes Calcium Handling in Chronic Heart Failure.  Cardiovascular Research  2011;91(3):447-455.
Bish LT, George I.  Myostatin serum levels in heart failure. Reply.  Eur J Heart Failure 2010;12(12):1379-1380.
George I, Xu K, Klotz S, Xydas S, Zhang G, Cerami A, Wang J.  Erythropoeitin Derivate Improves Left Ventricular Systolic Performance and Attenuates Left Ventricular Remodeling in Rats with Myocardial Infarct-Induced Heart Failure.  J Cardiovasc Pharm  2010;56(5):506-512.
George I, Xydas S, Klotz SA, Hay I, Chang J, Li Z, Protter AA, Oz MC, Wang J.  Long-term Effects of B-Type Natriuretic Peptide Infusion After Acute Myocardial Infarction.  J Cardiovasc Pharm  2010;55:14-20.
George I, Bish L, Kamakakkannan G, Oz MC, Naka Y, Sweeney L, Maybaum S.  Myostatin Activation in Patients with Advanced Heart Failure and After Mechanical Unloading.  Eur J Heart Failure  2010;12:444-453.
George I, Yi GH, Morrow B, Holmes J, Xu EX, Li Z, Protter AA, Oz MC, Wang J.  Prolonged Effects of B-Type Natriuretic Peptide Infusion on Cardiac Remodeling After Sustained Myocardial Injury.  Am J Phys-Heart Circ Phys 2009;297:H708-H717.
George I, Shah JN, Bacchetta M, Stewart A.  Stentless Bioprosthesis in Valved Conduits:  Implications for Pulmonary Reconstruction.  Ann Thorac Surg  2009;88:2022-2024.
Russo MJ, Davies RR, Hong KN, Chen JM, Argenziano M, Moskowitz A, Ascheim DD, George I, Stewart AS, Williams M, Gelijins A, Naka Y.  Matching High-Risk Recipients with Marginal Donor Organs is a Clinically Effective Strategy.  Ann Thorac Surg 2009;87:1066-71.
George I, Geddis MS, Lill Z, Lin H, Gomez T, Blank M, Oz MC, Goodman R.  Myocardial Function Improved by Electromagnetic Field Induction of Stress Protein hsp70.  J Cellular Physiol 2008:216;816-823.
George I, Colley P, Russo M, Martens T, Burke E, MC, Deng MC, Mancini DM, Naka Y.  Association of device surface and biomaterials with immunologic sensitization after mechanical support.  J Thorac Cardiovasc Surg 2008;135:1372-9.
Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, Mancini DM, Maybaum S.  Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.  J Heart Lung Transplant 2008;27(4):457-61.
George I, Cheng Y, Yi GH, Reiken S, Gu A, Tao YK, Muraskin J, Qin S, He KL, Hay I, Yu K, Oz MC, Holmes J, Burkhoff D, Wang J.  Bradycardic Therapy Improves Left Ventricular Function and Remodeling in Dogs with Coronary Embolization-Induced Chronic Heart Failure. J Pharm Exp Therap 2007;321(2):469-76.
Russo MJ, Chen JM, Sorabella RA, Martens TM, Garrido M, Davies RR, George I, Cheema FH, Mosca RS, Mital S, Ascheim DD, Argenziano M, Stewart AS, Oz MC, Naka Y.  Effect of ischemic time on survival following heart transplantation varies by donor age: an analysis of the United Network of Organ Sharing Database.  J Thorac Cardiovasc Surg 2007;133:554-9.
George I, Xydas S, Mancini DM, Lamanca J, DiTullio M, Marboe CC, Shane E, Schulman AR, Colley PM, Petrilli CM, Naka Y, Oz MC, Maybaum S.  Effect of Clenbuterol on Cardiac and Skeletal Muscle Function with Ventricular Assist Device Support. J Heart Lung Transplant 2006;25:1084-90.
George I, Xydas S, Topkara VK, Ferdinando C, Barnwell EC, Gableman L, Sladen R, Naka Y, Oz MC.  Clinical Indication for Use and Outcomes After Inhaled Nitric Oxide.  Annals of Thoracic Surgery 2006;82:2161-2169.
Russo MJ, Davies RR, Sorabella RA, Martens TM, George I, Cheema FH, Mital S, Mosca RS, Chen JM.  Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network of Organ Sharing Database.  J Thorac Cardiovasc Surg 2006;132(5):1208-12.
Bardakci H, Cheema FH, Topkara VK, Dang NC, Martens TP, Mercando ML, Forster CS, George I, Russo MJ, Oz MC, Esrig BC.  Discharge-to-Home Rates in Octogenarians Are Significantly Lower in Coronary Artery Bypass Grafting Patients.  Ann Thorac Surg 2007;83:483-489.
George I, Yi GH, Schulman AR, Morrow BT, Cheng Y, Gu A, Zhang G, Oz MC, Burkhoff D, Wang J.  A Polymerized Bovine Hemoglobin Oxygen Carrier Preserves Regional Myocardial Function and Reduces Infarct Size after Acute Myocardial Ischemia.  Am J Physiol – Heart Circ Phys 2006;291:H1126-H1137.
George I, Cheng Y, Yi GH, He KL, Li X, Oz MC, Holmes J, Wang J.  Effect of Passive Cardiac Containment on Ventricular Synchrony and Cardiac Function in Awake Dogs. Euro J Cardiothorac Surg 2007;31:55-64.
George I, Yi GH, He KL, Lee MJ, Calahan P, Zhang G, Gu A, Klotz S, Burkhoff DB, Wang J.  Direct Left Ventricle to Coronary Artery Stent Restores Perfusion to Ischemic Swine Myocardium.  Heart Surgery Forum 2006;9(5):E744-9.
Topkara VK, Dang NC, Barili F, Martens TP, George I, Cheema FH, Bardacki H, Ozcan AV, Naka Y.  Ventricular Assist Device use for the treatment of acute viral myocarditis.  J Thorac Cardiovasc Surg 2006;131(5):1190-1.
Topkara VK, Dang NC, Barili F, Cheema FH, Martens TP, George I, Bardakci H, Oz MC, Naka Y. Predictors and outcomes of continuous venovenous hemodialysis use after left ventricular assist device implantation.  J Heart Lung Transplant 2006;25(4):404-8.
George I, Smith CR.  The Future of TAVR.  Heart Disease (9th Edition).  Braunwald E.  Saunders, Elsevier Science, 2013. 
Grubbs, K, George I, Williams MR.  Transcatheter Valve-in-Valve Replacement as a Treatment for Failed Bioprosthetic Valves.  Cardiac Surgical Techniques (1st Edition).  Franco K, Roselli E, Slaughter M, Thourani V, 2013.
George I, Reiss GR, Williams MR.  Transcatheter Aortic Valve Replacement.  Mastery of Cardiothoracic Surgery, 3rd Edition.  Kaiser L, Kron I, Spray T.  Wolters Kluwer Health Inc, 2013.
George I, Williams MR.  Myocardial Revascularization after Acute Myocardial Infarction.  Cardiac Surgery in the Adult (4th Edition).  Cohn LH, Edmunds LH Jr.  The McGraw-Hill Companies, Inc., 2011.
George I, Oz MC.  Myocardial Revascularization after Acute Myocardial Infarction.  Cardiac Surgery in the Adult (3rd Edition).  Cohn LH, Edmunds LH Jr.  The McGraw-Hill Companies, Inc., 2007.