Physician’s Profile

Henry M. Spotnitz, MD

1
Vice-Chairman, Research & Information Systems, Department of Surgery
Director, Cardiovascular Surgery Research Lab
Affiliations: 
NewYork-Presbyterian/Columbia
Board Certificates: 
Thoracic and Cardiac Surgery
Surgery
Expertise: 
Open Heart Surgery
Thoraco Abdominal Aneurysm
Valve Reconstruction/Repair
Aortic Disease
Arrhythmia Surgery
Cardiac Electrophysiology
Thoracic Lung Cases
Emphysema
Bloodless Surgery
Heart Failure
Thoracic Aneurysm Surgery
Heart Valve Repair
Minimally Invasive Valve Repair
Off Pump Coronary Bypass Surgery
Aortic Aneurysm
Thoracic Outlet Syndrome
Esophageal Surgery
Barrett's Esophagus
Surgical Management of Lung Cancer
Mitral Valve Repair
Minimally Invasive Cardiac Surgery
Hyperhidrosis
Aneurysm Repair
Mitral/Aortic Valve Replacement
Mitral Valve Prolapse
Mitral Valve Surgery
Mediastinal Tumor
Mesothelioma
Arterial Insufficiency
Minimally Invasive Aneurysm Repair
Thymoma
Bicuspid Aortic Valve
Thoracic/Cardiothoracic Surgery
Esophageal Disease
Coronary Artery Bypass
Cystic Fibrosis
Esophageal Cancer
Marfan's Syndrome
Pacemaker Implant
Interests: 
Ventricular function in cardiac surgery
Biventricular pacing during cardiac surgery
Heterotopic isografts in cardiac surgery
Wearable computers in the operating room
Myocardial protection for surgical correction of cyanotic congenital heart disease
About: 

Clinically, I am known for arrhythmia surgery. I participated in clinical trials of defibrillators and pacemaker leads, including the CABG Patch Trial, the MUST trial, the AVID trial, CPI sponsored trials of the VentakP and P2 defibrillators, and Medtronic steroid eluting lead and biventricular pacing (MIRACLE) trials. I studied effects of ICD leads on ventricular compliance. I contributed books, instructional videos, and book chapters on ICD and pacemaker insertion and lectured in cardiac surgery courses of the American College of Surgeons and the New York Society for Thoracic Surgery. I developed unique clinical methods for insertion of transvenous pacemakers and defibrillators in infants and children.
I am the first George H. Humphreys, II, Professor of Surgery at Columbia, in recognition of translational research that applied two-dimensional echocardiography, high fidelity pressure recordings, ultrasonic flow probes, and conductance ventriculography to defining effects of surgery on cardiac function in animals and patients. I developed computerized analyses of hemodynamic data and computer-based clinical data management systems. I was supported by NIH and American Heart Association grants beginning in 1977. I am a former member of the Surgery and Bioengineering Study Section of NHLBI/NIH. My research included effects of surgery for congenital heart disease on ventricular geometry and function. My laboratory recently focused on temporary biventricular pacing for acute heart failure in humans during and after cardiac surgery. We demonstrated load dependence of biventricular pacing in animal models of acute heart failure and confirmed value of optimization of temporary biventricular pacing in selected patients after cardiac surgery in the BIPACS Trial. We explored the extension of our established protocols for intraoperative biventricular pacing to the study of acute intraoperative right ventricular dysfunction and single ventricle.

Publications: 
Spotnitz HM, Yeager KJ, Cabreriza SE, Vunjak-Novakovic G, Wang DY, Pearson GD. Introducer Development for Coronary Sinus Access From Parasternal Mediastinotomy. Innovations (Phila). 2015 Jul 15. [Epub ahead of print].
Brusen RM, Hahn R, Cabreriza SE, Cheng B, Wang DY, Truong W, Spotnitz HM. Wall thickness, pulmonary hypertension, and diastolic filling abnormalities predict response to postoperative biventricular pacing. J Cardiothorac Vasc Anesth. 2015 Feb 7, [Epub ahead of print].
*Wang A, Cabreriza SE, Cheng B, Shanewise JM, Spotnitz HM. Feasibility of speckle tracking echocardiography for assessment of left ventricular dysfunction after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2014;28(1):31-35.
*Lu JG, Pensiero A, Aponte-Patel L,Velez de Villa B, Rusanov A, Cheng B, Cabreriza SE, Spotnitz HM. Short-term reduction in intrinsic heart rate during biventricular pacing after cardiac surgery - A substudy of a randomized clinical trial. J Thorac Cardiovasc Surg. 2013;146(6):1494-1500.
International Working Group on Quantitative Optimization: Sohaib SM, Whinnett ZI, Ellenbogen KA, Stellbrink C, Quinn TA, Bogaard MD, Bordachar P, van Gelder BM, van Geldorp IE, Linde C, Meine M, Prinzen FW, Turcott RG, Spotnitz HM, Wichterle D, Francis DP. Cardiac resynchronisation therapy optimisation strategies: systematic classification, detailed analysis, minimum standards and a roadmap for development and testing. Int J Cardiol. 2013 Dec 10;170(2):118-131.
Buonanno M, Randers-Pehrson G, Bigelow AW, Trivedi S, Lowy FD, Spotnitz HM, Hammer SM, Brenner DJ. 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: in vitro studies. PLoS One. 2013 Oct 16;8(10):e76968.
*Liberman L, Spotnitz HM, Hordof AJ, Friedman RA, Starc TJ, Silver ES. Usefulness of transtelephonic monitoring in epicardial pacemaker systems. Pacing Clin Electrophysiol. 2013 Jun;36(6):684-687.
*Wang A, Cabreriza SE, T. Quinn TA, Richmond ME, Cheng B, Spotnitz HM. Regional and global strain changes during biventricular pacing in a porcine model of acute left ventricular volume overload. J Ultrasound Med 2013; 32:675-682.
*Spotnitz HM, Cabreriza SE, Wang DY, Quinn TA, Cheng B, Bedrosian LN, Aponte-Patel L, Smith CR. Primary endpoints of the biventricular pacing after cardiac surgery trial. Ann Thorac Surg 2013;96:808-815.
*Wang A, Cabreriza SE, Cheng B, Havalad V, Aponte-Patel L, Gonzalez G, Velez de Villa B, Cheng B, Spotnitz HM. Effects of biventricular pacing on left ventricular twist and strain in a porcine model of right heart failure. J Surg Res 2013;185(2):645-652.
*Wang DY, Kelly LA, Richmond ME, Quinn TA, Cheng B, Cabreriza SE, Naka Y, Stewart AS, Smith CR, Spotnitz HM. Feasibility of temporary biventricular pacing after off-pump coronary artery bypass grafting in patients with reduced left ventricular function. Texas Heart Inst J 2013;40(4):403-409.
Spotnitz HM: Application of intravascular dissection devices for closed chest coronary sinus lead extraction: an interdisciplinary approach (Invited Commentary). Ann Thorac Surg in press.
*Havalad V, Bacchetta M, Wang DY, Cabreriza SE, Aponte-Patel L, Cheng B, Spotnitz HM. Cardiac pacing: A novel approach to RV failure during pulmonary thromboendarterectomy. J Thorac Cardiovasc Surg. 2013;Apr; 145(4):1141-1143.
*Nguyen HV, Havalad V, Aponte-Patel L, Murata AY, Wang DY, Rusanov A, Cheng B, Cabreriza SE,  Spotnitz HM. Temporary biventricular pacing decreases the vasoactive-inotropic score after cardiac surgery – A substudy of a randomized clinical trial. J Thorac Cardiovasc Surg 2013 Aug;146(2):296-301.
Neely RC, Spotnitz HM. Salvage of permanent epicardial lead function by conversion of a bipolar to unipolar lead. J Cardiac Surg, 2012 Nov;27(6):771-3.
Wang A, Cabreriza SE, T. Quinn TA, Richmond ME, Cheng B, Spotnitz HM. Regional and global strain changes during biventricular pacing in a porcine model of acute left ventricular volume overload. J Ultrasound in Medicine, in press.
Spotnitz HM. Surgical Implantation of Pacemakers and automatic defibrillators. Cohn LH, ed. Cardiac Surgery in the Adult, 4e. New York: McGraw-Hill, 2012.
Nguyen HV, Havalad V, Aponte-Patel L, Murata AY, Wang DY, Rusanov A, Cheng B, Cabreriza SE, Spotnitz HM. Temporary biventricular pacing decreases the vasoactive-inotropic score after cardiac surgery - A substudy of a randomized clinical trial. JTCVS 2012 Jul 27. [Epub ahead of print].
Wong CC, Cabreriza SE, Chavez M, Wang DY, Gerrah R, Rusanov A, Yalamanchi V, Wang A, Cheng B, Spotnitz HM. Optimizing biventricular pacing during right ventricle pressure overload acutely improves mechanical dyssynchrony and function by 2-D speckle tracking. J Surg Res. 2012 Dec;178(2):571-7. Jun 21. [Epub ahead of print]
*Rubinstein B, Wang DY, Cabreriza SE, Richmond ME, Rusanov A, Quinn TA, Cheng B, Spotnitz HM. Response of mean arterial pressure to temporary biventricular pacing after chest closure during cardiac surgery. A substudy of the Biventricular Pacing After Cardiac Surgery (BiPACS) trial. J Thorac Cardiovasc Surg 2012 Dec;144(6):1445-1452.
Rusanov A, Wang DY, Cabreriza SE, Bedrosian LN, Karl SR, Richmond ME, Quinn TA, Cheng B, Spotnitz HM. Effect of atrioventricular conduction prolongation on optimization of paced atrioventricular delay for biventricular pacing after cardiac surgery. J Cardiothorac Vasc Anesth. 2012 Apr;26(2):209-16. Epub 2011 Oct 14. PMID: 22000982
Johnson CK, Cabreriza SE, Sahar RL, Rusanov A, Wang DY, Cheng B, Gendy MS, Quinn TA, Spotnitz HM. Clinical validation of a real-time data processing system for cardiac output and arterial pressure measurement during intraoperative biventricular pacing optimization. ASAIO J. 2012 May-Jun;58(3):191-PMID:22395120
Chambers S, Rusanov A, Spotnitz HM, Silver ES, Liberman L. Durability of repaired pacemaker leads in the pediatric population. J Interv Card Electrophysiol. 2011;30:267-71.
Wang DY, Spotnitz HM. Study of acute hemodynamic effects of temporary cardiac resynchronization therapy by Straka et al. Pacing Clin Electrophysiol. 2011 Dec;34(12):1705; author reply 1705-6. Epub 2011 Oct 5. PMID:21972930.
Spotnitz HM, Wang DY. Middle and posterior cardiac veins: An underused option for ventricular pacing. J Thorac Cardiovasc Surg. 2011 Dec 9. [Epub ahead of print] PMID: 22169450
Spotnitz HM. Ventricular function in surgery for congenital Heart Disease. World J of Surg 2010 Apr;34(4):669-74. Review
Bonney WJ, Spotnitz HM, Liberman L, Silver ES, Ceresnak SR, Hordof AJ, Pass RH. Survival of transvenous ICD leads in young patients. Pacing Clin Electrophysiol 2010;33:186-91.
George E, Cabreriza SE, Quinn TA, Rusanov A, Gerrah R, Broyles JM, Weinberg AD, Spotnitz HM. Validation of automated monitoring of cardiac output for biventricular pacing optimization. ASAIO J. 2010; 56:265-269.
Gray RG, Cabreriza SE, Quinn TA, Weinberg AD, Spotnitz HM. Feasibility of in vivo pressure measurement using a pressure-tip catheter via transventricular puncture. 2010; 56:194-199.
Dizon JM, Quinn TA, Cabreriza SE, Wang D, Spotnitz HM, Hickey K, Garan H. Real-time stroke volume measurements for the optimization of cardiac resynchronization therapy parameters. Europace. 2010 Sep;12(9):1270-4. Epub 2010 Jun 4.
Spotnitz ME, Richmond ME, Quinn TA, Cabreriza SE, Wang DY, Albright CM, Weinberg AD, Dizon JM, Spotnitz HM. Relation of QRS shortening to cardiac output to during temporary resynchronization therapy after cardiac surgery. ASAIO J. 2010; Sep-Oct;56(5):434-40.
Gerrah R, Cabreriza SE, Rusanov A, Romanov A, Khan AR, Spotnitz HM. Developing and optimizing a chronic cyanotic swine model. J Surg Res. 2010; Mar 26. Epub ahead of print.
Rusanov A, Spotnitz HM. Salvage of a failing bifurcated bipolar epicardial lead with conductor fracture running head: salvage of a fractured epicardial lead. Ann Thorac Surg. 2010;90:649-651.
Spotnitz ME, Wang DY, Quinn TA, Richmond ME, Rusanov A, Johnston T, Cheng B, Cabreriza SE, Spotnitz HM. Hemodynamic stability during biventricular pacing after cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2010 Jul 16. [Epub ahead of print]
Wang DY, Richmond ME, Quinn TA, Mirani A, Rusanov A, Yalamanchi V, Weinberg AD, Cabreriza SE, Spotnitz HM. Optimized temporary biventricular pacing acutely improves intraoperative cardiac output after weaning from cardiopulmonary bypass - a substudy of a randomized clinical trial. J Thorac Cardiovasc Surg. 2010 Aug 25.
[Epub ahead of print].
Wang DY, Gerrah R, Rusanov A, Yalamanchi V, Cabreriza SE, Spotnitz HM. Left ventricular pacing lead insertion via the coronary sinus cardioplegia cannula: a novel method for temporary biventricular pacing during reoperative cardiac surgery. J Thorac Cardiovasc Surg. 2011;142:73-6.
Rusanov A, Spotnitz HM. A 15-year experience with permanent pacemaker and defibrillator lead and patch extractions. Ann Thorac Surg 2010;89:44-50.
Bonney WJ, Spotnitz HM, Liberman L, Silver ES, Ceresnak SR, Hordof AJ. Survival of Transvenous ICD Leads in Young Patients. PACE 2009; in press [Epub ahead of print]
Quinn TA, Cabreriza SE, Richmond ME, Weinberg AD, Holmes JW, Spotnitz HM. Simultaneous variation of ventricular pacing site and timing with biventricular pacing during acute ventricular failure improves function by interventricular assist. Am J Physiol Heart Circ Physiol. 2009;297(6): H2220-6.
Spotnitz HM. Ventricular Function in Surgery for Congenital Heart Disease. World J Surg. 2009 Nov 17. [Epub ahead of print]e.
Silver ES, Liberman L, Spotnitz HM, Hordof AJ, Chung WK, Pass RH. Long QT syndrome due to a novel mutation in SCN5A: Treatment with ICD placement at one month and left cardiac sympathetic denervation at three months of age J Interv Card Electrophysiol, 2009 Oct;26(1):41-5.
Booth JH, Quinn TA, Richmond ME, Cabreriza SE, Weinberg AD, Spotnitz HM. Cardiac output measurement by arterial pressure waveform analysis during optimization of biventricular pacing after cardiac surgery. ASAIO J. 2009 Nov-Dec;55(6):587-91.
Spotnitz HM, Quinn TA. The surgeon's role in resynchronization therapy. Touch Briefings in London. http://www.touchbriefings.com/cdps/cditem.cfm?nid=3135&cid=5
Marc E. Richmond, Santos E. Cabreriza, Jason P. Van Batavia, T. Alexander Quinn, MS, Joshua P. Kanter, Alan D. Weinberg, Ralph S. Mosca, Jan M. Quaegebeur, Henry M. Spotnitz. Direction of Pre-Operative Shunting Affects Ventricular Mechanics after Tetralogy of Fallot Repair. In Revision.
Albright CM, Quinn TA, Berberian G, Cabreriza SE, Garofalo CA, Weinberg AD, Dizon JM, Spotnitz HM. Measurement of QRS duration for biventricular pacing optimization. ASAIO J 2008 Jul-Aug;54(4):335-40.
Richmond ME, Cabreriza SE, Van Batavia JP, Quinn TA, Kanter JP, Weinberg AD, Mosca RS, Quaegebeur JM, Spotnitz HM. Direction of pre-operative ventricular shunting affects ventricular mechanics after tetralogy of Fallot repair. Circulation 2008 Dec 2;118(23):2338-44.
Spotnitz HM. Surgical Implantation of Pacemakers and Automatic Defibrillators. _Cohn LH, ed. Cardiac Surgery in the Adult. New York: McGraw-Hill, 2008:1395-1428 and http://cardiacsurgery.ctsnetbooks.org/cgi/content/full/3/2008/1395?ck=nck.
Liberman L, Pass RH, Hordof AJ, Spotnitz HM. Late onset of heart block after open heart surgery for congenital heart disease. Pediatr Cardiol 2008 Jan;29(1):56-9.
Berberian G, Quinn TA, Cabreriza SE, Kenny JS, Garofalo CA, Weinberg AD, Spotnitz HM. Left ventricular pacing site and timing optimization during biventricular pacing using a muli-electrode patch in pigs. J Thorac Cardiovasc Surg 2007 Sep;134(3):574-8.
Berberian G, Cabreriza SE, Quinn TA, Garofalo CA, Spotnitz HM. Left ventricular pacing site-timing optimization during biventricular pacing using a multielectrode patch. Ann. Th. Surg. 2006 Dec;82(6):2292-4.
Quinn TA, Berberian G, Cabreriza SE, Maskin LJ, Weinberg AD, Holmes JW, Spotnitz HM. Effects of Sequential Biventricular Pacing During Acute Right Ventricular Pressure Overload. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2380-7. Epub 2006 Jun 2.
Garofalo CA, Cabreriza SE, Quinn TA, Weinberg AD, Quaegebeur JM, Spotnitz HM, Mosca RS. Diastolic properties predict short-term postoperative risk and duration of pleural effusions after the fontan operation. Circulation 2006 Jul 4;114(1 Suppl):I56-61.
Berberian G, Quinn TA, Cabreriza SE, Kenny JS, Weinberg AD, Spotnitz HM. Load dependence of cardiac output in biventricular pacing: left ventricular volume overload in pigs. J Thorac Cardiovasc Surg 2006 Mar;131(3):666-70.
Berberian G, Kanter JP, Quinn TA, Curtis LJ, Cabreriza SE, Stewart AS, Oz MC, Spotnitz HM. Optimized perioperative biventricular pacing in setting of right heart failure: A case report. Europace 2005 Jul;7:385-7.
Spotnitz HM. Optimizing temporary perioperative cardiac pacing (Editorial). J Thorac Cardiovasc Surg 2005;129:5-8.
Hart JP, Cabreriza SE, Walsh R, Printz BF, Blumenthal BF, Park DK, Zhu AJ, Gallup CG, Weinberg AD, Hsu DT, Mosca RS, Galantowicz ME, Quaegebeur JM, Spotnitz HM. Echocardiographic Analysis of Ventricular Geometry and Function During Repair of Congenital Septal Defects. Ann Th Surg 2004;77:53-60.
Rabkin DG, Cabreriza SE, Curtis LJ, Mazer SP, Kanter JP, Weinberg AD, Hordof AJ, Spotnitz HM. Load dependence of cardiac output in biventricular pacing: Right ventricular pressure overload in pigs. J Thorac Cardiovasc Surg 2004 June;127(6): 1713-1722.
Rabkin DG, Curtis LJ, Cabreriza SE, Weinberg AD, Spotnitz HM. Load dependence of cardiac output in biventricular pacing: Right ventricular volume overload in pigs. J Thorac Cardiovasc Surg, 2004 July;128(1): 98-102.
Spotnitz HM: Cardiac Pacing and Defibrillators, in Edwards NM, Maurer MS, Wellner RB, eds., Aging, Heart Disease, and its management. Facts and Controversies. Humana Press, Totowa NJ, 2003, 323-343.
Rabkin DG, Cabreriza SA, LaCorte JC, Weinberg AD, Coku L, Walsh R, Mosca R, Spotnitz HM. Na/H ion exchange inhibition preserves ventricular function after ventricular fibrillation in the intact swine heart. J Thorac Cardiovasc Surg. 2003;125:1499-1509.
Rabkin DG, Weinberg AD, Spotnitz HM. Optimizing probucol administration to preserve left ventricular compliance after reperfusion injury in the heterotopic rat heart isograft. J Heart Lung Transplant 2003;22:959-966.
Rabkin DG, Cabreriza SE, LaCorte JC, Weinberg AD, Coku L, Walsh R, Mosca RS, Spotnitz HM. Cariporide is cardioprotective after iatrogenic ventricular fibrillation in the intact swine heart. Ann Thorac Surg 2003;76:1264-9.
Spotnitz HM, Spotnitz MD, Weindberg AD, Pass RH, Hordof AJ, Gersony WM: Decreased endocardial lead survival in infants. Tse H-F, Lee KLF, Lau C-P eds, Proceedings of XIIth World Congress on Cardiac Pacing and Electrophysiology, Hong Kong, 2003. Monduzzi Editore, 915-19.