Physician’s Profile

Koji Takeda, MD, PhD

Assistant Attending Surgeon, Cardiac Surgery
Affiliations: 
NewYork-Presbyterian/Columbia
Expertise: 
Cardiac Surgery
General Surgery
Heart Failure
Heart Transplantation
Honors: 

2009 American College of Chest Physicians Award, Japan Branch

2005 Chief Resident of the Year, National Cardiovascular Center

2005 Resident of the Year, National Cardiovascular Center

1999 Best score award in Ob/Gyn

Interests: 
Adult cardiovascular surgery especially in the treatment of congestive heart failure
Myocardial ischemia/reperfusion injury
Myocardial regeneration therapy / tissue engineering
About: 

Koji Takeda, MD, PhD is Assistant Professor of Surgery, Columbia University Medical Center and Assistant Attending Surgeon, NewYork-Presbyterian as of January 1, 2014.

Dr. Takeda has been a cardiac surgery fellow at NewYork-Presbyterian/Columbia specializing in heart failure surgery, LVAD implantation, and heart transplantation since January 2013. As a dual fellow and full attending surgeon this year, he continues to focus on the management of heart failure as part of his transition toward leadership of these clinical specialties in the Section of Cardiac Surgery. In addition to his clinical practice, Dr. Takeda has research interests in mechanical circulatory support, heart transplantation, and cardiac regeneration therapy.

Dr. Takeda completed his medical training, post-graduate training, residency and fellowship in Osaka, Japan, after which he completed an advanced cardiovascular surgery fellowship at Northwestern University, Chicago. He is the recipient of multiple honors and awards including the American College of Chest Physicians Award, Japan Branch, 2009; and chief resident award and best resident award, 2005, at the National Cardiovascular Center, Osaka, Japan.

Publications: 
Han J, Takeda K, Takayama H, Kurlansky PA, Mauro CM, Colombo PC, Yuzefpolskaya M, Fukuhara S, Truby LK, Topkara VK, Garan AR, Mancini DM, Naka Y. Durability and clinical impact of tricuspid valve procedures in patients receiving a continuous-flow left ventricular assist device. J Thorac Cardiovasc Surg. 2016 Feb;151(2):520-527
Fukuhara S, Takeda K, Garan AR, Kurlansky P, Hastie J, Naka Y, Takayama H. Contemporary mechanical circulatory support therapy for postcardiotomy shock. Gen Thorac Cardiovasc Surg. 2016 Feb 13.
Fukuhara S, Takeda K, Garan AR, Kurlansky P, Hastie J, Naka Y, Takayama H. Contemporary mechanical circulatory support therapy for postcardiotomy shock. Gen Thorac Cardiovasc Surg. 2016 Feb 13.
Fukuhara S, Takeda K, Polanco AR, Takayama H, Naka Y. Prolonged continuous-flow left ventricular assist device support and posttransplantation outcomes: A new challenge. J Thorac Cardiovasc Surg. 2016 Mar;151(3):872-880
Wever-Pinzon O, Naka Y, Garan AR, Takeda K, Pan S, Takayama H, Mancini DM, Colombo P, Topkara VK. National trends and outcomes in device-related thromboembolic complications and malfunction among heart transplant candidates supported with continuous-flow left ventricular assist devices in the United States. J Heart Lung Transplant. 2016 Mar 11
Willey JZ, Gavalas MV, Trinh PN, Yuzefpolskaya M, Reshad Garan A, Levin AP, Takeda K, Takayama H, Fried J, Naka Y, Topkara VK, Colombo PC. Outcomes after stroke complicating left ventricular assist device. J Heart Lung Transplant. 2016 Mar 30.
Sorabella RA, Guglielmetti L, Bader A, Gomez A, Takeda K, Chai PJ, Takayama H, Bacha EA, Naka Y, George I. The Use of Hypothermic Circulatory Arrest During Heart Transplantation Does Not Worsen Posttransplant Survival. Ann Thorac Surg. 2016 May 18.
Topkara VK, Knotts RJ, Jennings DL, Garan AR, Levin AP, Breskin A, Castagna F, Cagliostro B, Yuzefpolskaya M, Takeda K, Takayama H, Uriel N, Mancini DM, Eisenberger A, Naka Y, Colombo PC, Jorde UP. Effect of CYP2C9 and VKORC1 Gene Variants on Warfarin Response in Patients with Continuous-Flow Left Ventricular Assist Devices (CF-LVADs). ASAIO J. 2016 Jun 1.
Ikegami H, Kurlansky P, Takeda K, Naka Y. Challenges faced in long term ventricular assist device support. Expert Rev Med Devices. 2016 Aug;13(8):727-40.
Topkara VK, Garan AR, Fine B, Godier-Furnémont AF, Breskin A, Cagliostro B, Yuzefpolskaya M, Takeda K, Takayama H, Mancini DM, Naka Y, Colombo PC. Myocardial Recovery in Patients Receiving Contemporary Left 
Ventricular Assist Devices: Results From the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Circ Heart Fail. 2016 Jul;9(7).
Ton VK, Garan AR, Takeda K, Takayama H, Naka Y. LVAD implantation following repair of acute postmyocardial infarction ventricular septal defect. J Card Surg. 2016 Aug 8
Takeda K, Arthur R. Garan, Veli K Topkara, Ajay J. Kirtane, Dimitri Karmpaliotis, Paul Kurlansky, Melana Yuzefpolskaya, Paolo C Colombo, Yoshifumi Naka, Hiroo Takayama. Novel minimally invasive surgical approach using external ventricular assist device and extracorporeal membrane oxygenation in refractory cardiogenic shock. Eur J Cardiothorac Surg in press.
Kainuma S, Taniguchi K, Toda K, Shudo Y, Takeda K, et al. B-type natriuretic peptide response and reverse left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy. J Cardiol. 2015. In press
Takayama H, Landes E, Truby L, Fujita K, Kirtane AJ, Mongero L, Yuzefpolskaya M, Colombo PC, Jorde UP, Kurlansky PA, Takeda K, Naka Y. Feasibility of smaller arterial cannulas in venoarterial extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg. 2015 May;149(5):1428-33
Truby L, Mundy L, Kalesan B, Kirtane A, Colombo PC, Takeda K, Fukuhara S, Naka Y, Takayama H. Contemporary Outcomes of Venoarterial Extracorporeal Membrane Oxygenation for Refractory Cardiogenic Shock at a Large Tertiary Care Center. ASAIO J. 2015 Jul-Aug;61(4):403-9.
Garan AR, Levin AP, Topkara V, Thomas SS, Yuzefpolskaya M, Colombo PC, Takeda K, Takayama H, Naka Y, Whang W, Jorde UP, Uriel N. Early post-operative ventricular arrhythmias in patients with continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2015
Tsukashita M, Takayama H, Takeda K, et al. Effect of pulmonary vascular resistance before left ventricular assist device implantation on short- and long-term post-transplant survival. J Thorac Cardiovasc Surg. 2015 in press.
Pan S, Aksut B, Wever-Pinzon OE, Rao SD, Levin AP, Garan AR, Fried JA, Takeda K, Hiroo T, Yuzefpolskaya M, Uriel N, Jorde UP, Mancini DM, Naka Y, Colombo PC, Topkara VK. Incidence and predictors of myocardial recovery on long-term left ventricular assist device support: Results from the united network for organ sharing database. J Heart Lung Transplant. 2015.
Levin AP, Jaramillo N, Garan AR, Takeda K, Takayama H, Yuzefpolskaya M, Mancini DM, Naka Y, Colombo PC, Topkara VK. Outcomes of contemporary mechanical circulatory support device configurations in patients with severe biventricular failure. J Thorac Cardiovasc Surg. 2015 Oct 22
Fukuhara S, Takeda K, Chiuzan C, Han J, Polanco AR, Yuzefpolskaya M, Mancini DM, Colombo PC, Topkara VK, Kurlansky PA, Takayama H, Naka Y. Concomitant aortic valve repair with continuous-flow left ventricular assist devices: Results and implications. J Thorac Cardiovasc Surg. 2015. In press.
Landes E, Naka Y, Takeda K, Takayama H. Single-center experience with a minimally invasive apicoaxillary external ventricular assist device. J Thorac Cardiovasc Surg. 2014 Aug 6.
Takeda K, Takayama H, Kalesan B, Uriel N, Colombo PC, Jorde UP, Naka Y. Long-term outcome of patients on continuous-flow left ventricular assist device support. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1606-14
Takeda K, Takayama H, Kalesan B, et al. Outcome of cardiac transplantation in patients requiring prolonged continuous-flow left ventricular assist device support. J Heart Lung Transplant. In press.
Sorabella RA, Yerebakan H, Walters R, Takeda K, et al. Comparison of Outcomes After Heart Replacement Therapy in Patients Over 65 Years Old. Ann Thorac Surg. 2014. In press.
Takeda K, et al. Late right heart failure during continuous-flow left ventricular assist device support adversely affects posttransplant outcome. J Heart Lung Transplant. In press
Takeda K, et al. Incidence and clinical significance of late right heart failure during continuous-flow left ventricular assist device support. J Heart Lung Transplant. In press
Takayama H, Takeda K, Doshi D, Jorde UP. Curr Opin Cardiol. Short-term continuous-flow ventricular assist devices. Long-term outcome of patients on continuous-flow left ventricular assist device support. 2014 May;29(3):266-74.
Takeda Koji, Hiroo Takayama, Bindu Kalesan, Nir Uriel, Paolo C. Colombo, Ulrich P. Jorde, Yoshifumi Naka. The Journal of Thoracic and Cardiovascular Surgery. 2014 April 10 (published online; awaiting print publication).
Takeda K, Naka Y, Yang JA, Uriel N, Colombo PC, Jorde UP, Takayama H. Outcome of unplanned right ventricular assist device support for severe right heart failure after implantable left ventricular assist device insertion. J Heart Lung Transplant. 2014 Feb;33(2):141-8.
Takeda K, Naka Y, Yang JA, Uriel N, Colombo PC, Jorde UP, Takayama H. Timing of temporary right ventricular assist device insertion for severe right heart failure after left ventricular assist device implantation. ASAIO J. 2013 Nov-Dec;59(6):564-9.
Takeda K, Miyata H, Motomura N, et al. Contemporary Perioperative Results of Heart Valve Replacement in Dialysis Patients: Analysis of 1616 Patients from the Japan Adult Cardiovascular Surgery Database. J Heart Valve Dis.
Kainuma S, Taniguchi K, Daimon T, Sakaguchi T, Funatsu T, Miyagawa S, Kondoh H, Takeda K, Shudo Y, Masai T, Ohishi M, Sawa Y. Mitral valve repair for medically refractory functional mitral regurgitation in patients with end-stage renal disease and advanced heart failure. Circulation. 2012 Sep 11;126(11 Suppl 1):S205-13.
Shudo Y, Nakatani S, Sakaguchi T, Miyagawa S, Yoshikawa Y, Takeda K, Saito S, Takeda Y, Sakata Y, Yamamoto K, Sawa Y. Left ventricular mechanics following restrictive mitral annuloplasty for functional mitral regurgitation: two-dimensional speckle tracking echocardiographic study. Echocardiography. 2012;29(4):445-50.
Yamauchi T, Miyata H, Sakaguchi T, Miyagawa S, Yoshikawa Y, Takeda K, Coronary Artery Bypass Grafting in Hemodialysis-Dependent Patients. Circ J. 2012 Feb 14.
Takeda K, Ahmad U, Malaisrie SC, et al. Successful implantation of HeartWare HVAD left ventricular assist device with concomitant ascending and sinus of valsalva aneurysms repair. J Artif Organs. 2012.
Shudo Y, Taniguchi K, Takeda K, et al. Serial multidetector computed tomography assessment of left ventricular reverse remodeling, mass, and regional wall stress after restrictive mitral annuloplasty in dilated cardiomyopathy. J Thorac Cardiovasc Surg. 2011 Dec 9.
Takeda K, Lee R. Early bioprosthetic valve failure caused by preserved native mitral valve leaflets. Interact Cardiovasc Thorac Surg. 2012;Feb;14(2):226-7.
Kainuma S, Taniguchi K, Takeda K, et al. Does Stringent Restrictive Annuloplasty for Functional Mitral Regurgitation Cause Functional Mitral Stenosis and Pulmonary Hypertension? Circulation. 2011 Sep 13;124(11 Suppl):S97-106.
Shudo Y, Taniguchi K, Takeda K, et al. Restrictive Mitral Annuloplasty with or without Surgical Ventricular Restoration in Ischemic Dilated Cardiomyopathy with Severe Mitral Regurgitation. Circulation. 2011 Sep 13;124(11 Suppl):S107-14.
Takeda K, Masai T, Ishida M et al. Unusual presentation of multiple recurrent cardiac sarcomas as acute acalculous cholecystitis caused by rapid expansion into right cardiac chamber; Report of a Case. Surg Today 2011 Nov 10.
Takeda K, Sakaguchi T, Miyagawa S, et al. The extent of early left ventricular reverse remodeling is related to the mid-term outcomes after restrictive mitral annuloplasty in patients with non-ischemic cardiomyopathy and functional mitral regurgitation. Eur J Cardiothorac Surg. 2011 Oct 18.
Saito T, Masai T, Takeda K, et al. A case of successful valve repair for aortic insufficiency associated with discrete subaortic stenosis. Ann Thorac Cardiovasc Surg. 2011 Oct 25;17(5):521-3. Epub 2011 Jul 13.
Sunagawa G, Masai T, Takeda K, et al. Successful bridge to recovery in a patient surviving fatal device-related complications after implantation of a Toyobo left ventricular assist system. J Artif Organs. 2011 Dec;14(4):364-6. Epub 2011 Jul 19.
Kainuma S, Masai T, Yoshitatsu M, Miyagawa S, Yamauchi T, Takeda K, et al. Advanced left-atrial fibrosis is associated with unsuccessful maze operation for valvular atrial fibrillation. Eur J Cardiothorac Surg. 2011 Jul;40(1):61-9. Epub 2011 Jan 7.
Takeda K, Matsumiya G, Hamada S, et al. Left ventricular basal myocardial scarring detected by delayed enhancement magnetic resonance imaging predicts outcomes after surgical therapies for patients with ischemic mitral regurgitation and left ventricular dysfunction. Cir J. 2010;75;148-56.
Kamata S, Sakaguchi T, Miyagawa S, Yoshikawa Y, Yamauchi T, Takeda K et al. The first clinical case in Japan of destination therapy using the Jarvik 2000 left ventricular assist device. J Artif Organs 2010 Sep;13(3):170-3. Epub 2010 Aug 12.
Takeda K, Taniguchi K, Shudo Y, et al. Mechanism of beneficial effects of restrictive mitral annuloplasty in patients with dilated cardiomyopathy and functional mitral regurgitation. Circulation 2010 Sep 14;122(11 Suppl):S3-9.
Shudo Y, Matsumiya G, Sakaguchi T, Miyagawa S, Yoshikawa Y, Yamauchi T, Takeda K, et al. Assessment of changes in mitral valve configuration with multidetector computed tomography: impact of papillary muscle imbrication and ring annuloplasty. Circulation 2010 Sep 14;122(11 Suppl):S29-36.
Shudo Y, Taniguchi K, Takeda K et al. Assessment of regional myocardial wall stress before and after surgical correction of functional ischaemic mitral regurgitation using multidetector computed tomography and novel software system. Eur J Cardiothorac Surg. 2010;38(2):163-70.
Shudo Y, Matsumiya G, Sakaguchi T, Miyagawa S, Yoshikawa Y, Yamauchi T, Takeda K, et al. The impact of surgical ventricular reconstruction for ischemic dilated cardiomyopathy on restrictive filling pattern. Gen Thorac Cardiovasc Surg. 2010;58(8):399-404.
Takeda K, Matsumiya G, Sakaguchi T, et al. Impact of untreated mild-to-moderate mitral regurgitation at the time of isolated aortic valve replacement on late adverse outcome. Eur J Cardiothorac Surg. 2010 May;37(5):1033-8. Epub 2010 Apr 1.
Obana M, Maeda M, Takeda K, et al. Therapetic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation. 2010;121:684-91.
Shudo Y, Matsumiya G, Takeda K, et al. Novel software package for quantifing local circumferential myocardial stress. Int J Cardiol. 2009 Jan 9.
Yamauchi T, Masai T, Takeda K, et al. Percutaneous cardiopulmonary support after acute myocardial infarction at the left main trunk. Ann Thorac Cardiovasc Surg. 2009:15:93-7.
Takeda K, Matsumiya G, Matsue H, at al. Noninvasive assessment of cardiac function during ventricular assisst system support using 64-row multidetector computed tomographic angiography. J Thorac Cardiovasc Surg. 2008:136:1602-3.
Takeda K, Matsumiya G, Matsue H, at el. Use of quantitative analysis of remote myocardial fibrosis with delayed enhancement magnetic resonance imaging to predict outcomes after surgical ventricular restoration for ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2008:136:1514-21.
Takeda K, Matsumiya G, Sakaguchi T et al. Long-term results of left ventricular reconstructive surgery in patients with ischemic dilated cardiomyopathy: a multicenter study. Cir J. 2008:72:1730-6.
Takeda K, Matsymiya G, Matsue H, et al. Left ventricular reconstructive surgery in ischemic dilated cardiomyopathy complicated with cardiogenic shock. Ann Thorac Surg. 2008:85:1339-43.
Takeda K, Imanaka H, Takeuchi M, et al. A case of mediastinitis during steroid therapy for repeated acute respiratory distress symdrome during perioperative period. J Jpn Soc Intensive Care Med. 2008:15:101-2.
Uemura H, Kagisaki K, Adachi I, Takeda K, et al. Aortic valvar involvement in patients with undergoing closure of ventricular septal difect via the pulmonary trunk. Int J Cardiol. 2008:129:26-31.
Kainuma S, Masai T, Yamauchi T, Takeda K, et al. Primary malignant pericardial mesothelioma presenting as pericardial constriction. Ann Thorac Cardiovasc Surg. 2008:14:396-8.
Kainuma S, Masai T, Yamauchi T, Takeda K, et al. Chronic expanding intrapericardial hematoma after coronary artery bypass surgery presenting with congestive heart failure. Ann Thorac Cardiovasc Surg. 2008:14:52-4.
Yamauchi T, Masai T, Takeda K, et al. Severely calcified constrictive pericarditis simulating a mediastinal tumor and obstructing the right ventricular inflow tract. Ann Thorac Cardiovasc Surg. 2007:13:410-2.
Takeda K, Matsumiya G, Nishimura M, et al. Giant circumflex coronary artery aneurysm with cyctic medial necrosis in a non-Marfan patient. Ann Thorac Surg. 2007:83:668-70.
Takeda K, Matsumiya G, Iwata K, et al. Successful reconstructive surgery for isolated mitral insufficiency associated with Williams syndrome: report of a case. Surg Today. 2007:37:237-9.
Takeda K, Kobayashi J, Nakajima H et al. Valve repair with maze procedure in acromegaly. Asian Cardiovasc Thorac Ann. 2006:14:e68-70.
Takeda K, Sawa Y. Unusual thrombus formation in the aorta after apicoaortic conduit for severe aortic stenosis. Osaka Heart Club 2006 (in Japanese).
Takeda K, Matsumiya G, Takano H, et al. Unusual thrombus formation in the aorta after apicoaortic conduit for severe aortic stenosis. J Thorac Cardiovasc Surg. 2006:132:155-6.
Takeda K, Uemura H, Kagisaki K, et al. Histologic findings after explantation of a modified expanded polytetrafluoroethylene graft used for clinical systemic-to-pulmonary shunting. J Thorac Cardiovasc Surg. 2005:130:934-5.
Takeda K, Yamasaki Y, Yumiba T, et al. A resected case of gastric cancer using an implantation of temporary IVC filter for preventing pulmonary embolism. (in Japanese) Nihon rinsyogekagakkai zasshi. 2002:63:618-622.