Researcher’s Profile

Emily J. Tsai, MD, FACC, FAHA


Dr. Tsai is a physician-scientist who focuses on the molecular mechanisms of heart failure, specifically the dysregulation of nitric oxide signaling within heart cells and the pathobiology of right ventricular dysfunction. She gained early scientific training in diverse fields ranging from neurophysiology to virology and immunology and subsequently pursued post-graduate scientific training in molecular cardiology. Accordingly, Dr. Tsai uses multidisciplinary and integrative approaches to investigating the molecular pathophysiology of heart failure. A translational investigator, Dr. Tsai also analyzes biological samples of heart failure patients to direct mechanistic studies in in vivo animal models as well as in vitro cell culture systems. The ultimate goal of the Tsai laboratory is to discover novel approaches for the treatment of chronic heart failure, in particular medically treated chronic heart failure (Stage C) and with an emphasis on preventing and reversing right ventricular failure. The Tsai lab is also interested in gender differences in the molecular signaling of heart failure.

Dr. Tsai has received national recognition for her research accomplishments. Her research awards include the 2017 American College of Cardiology Presidential Career Development Award, the 2017 Lewis Katz Cardiovascular Research Prize, the inaugural 2016 M. Irene Ferrer Scholar Award, the 2015 Columbia University Provost's Grant for Junior Faculty Who Contribute to the Diversity Goals of the University, and the 2012 Jay N. Cohn New Investigator Award in Basic Science from the Heart Failure Society of America. Dr. Tsai has received numerous research grants including an NHLBI R01, an NHLBI K08 Career Development Award, an NHLBI R03, and the AHA National Scientist Development Grant.

Dr. Tsai reviews grants for the American Heart Association and is an author of the 2013 ACCF/AHA Guideline for the Management of Heart Failure.


Emily J. Tsai, MD, FACC, FAHA, is an Assistant Professor of Medicine in the Department of Medicine, Division of Cardiology. She is an attending physician in the Center for Advanced Cardiac Care at New York-Presbyterian Hospital at the Columbia University Irving Medical Center. Board-certified in Cardiovascular Medicine and Advanced Heart Failure and Transplant Cardiology, Dr. Tsai specializes in caring for heart failure patients who require, or have received, a ventricular assist device or heart transplant.

Dr. Tsai is a magna cum laude graduate in engineering sciences of Harvard College. She received her MD cum laude from Harvard Medical School in the Harvard-MIT Division of Health Sciences and Technology. She completed internal medicine residency training at the Hospital of the University of Pennsylvania and cardiology fellowship at The Johns Hopkins Hospital. While at Hopkins, Dr. Tsai focused her clinical training in advanced heart failure and transplant cardiology. Supported by a Ruth L. Kirschstein National Research Service Award, Dr. Tsai also completed post-doctoral basic cardiovascular research training at Johns Hopkins University in the laboratory of David A. Kass, MD, FAHA. After her post-doctoral fellowship, Dr. Tsai was recruited to Temple University School of Medicine as an assistant professor of medicine and physiology and a principal investigator in its Cardiovascular Research Center. In 2015, Dr. Tsai joined the faculty of Columbia University College of Physicians & Surgeons and established her laboratory in integrative cardiac pathophysiology.