Researcher’s Profile

Paolo C. Colombo, MD

Assistant Attending Physician, Center for Advanced Cardiac Care
Assistant Attending Physician, Coronary Care Unit
Medical Director Mechanical of the Circulatory Support Program
Director, Center for Advanced Cardiac Care
Overview: 

Contributions to Science

1) Characterization of the pathophysiologic role of venous congestion in advanced heart failure. Dr. Colombo's research has contributed to the understanding of the pathophysiology of advanced heart failure.  We have provided experimental evidence, from animal and human models, that venous congestion is not simply an epiphenomenon of advanced heart failure, but rather a key contributor to the pathophysiology of acute decompensation through vasoactive, inflammatory, oxidative and metabolic mechanisms.

Colombo PC, Banchs JE, Lachmann J, Malla S, Celaj S, Nicholas B. DuBois NB, Talreja A, Ashton AW, Jorde UP, Ware JA, Le Jemtel TH. Vascular Endothelial Cell Activation in Patients With Decompensated Heart Failure. Response to Short-Term Inotropic Therapy. Circulation 111:58-62, 2005. PMID:15611373.

Colombo PC, Rastogi S, Onat D, Zaca V, Gupta RC, Jorde UP, Sabbah HD. Activation of Endothelial Cells in Conduit Veins of Dogs With Heart Failure and Veins of Normal Dogs Following Vascular Stretch by Acute Volume Loading. J Cardiac Failure 15:457-63, 2009. PMID: 19477407.

Colombo PC, Onat D, Harxhi A, Demmer RT, Hayashi Y,  Jelic S, LeJemtel TH, Bucciarelli L, Kebschull M, Papapanou P, Uriel N, Schmidt AM, Sabbah HN, Jorde UP. Peripheral Venous Congestion Causes Inflammation, Neurohormonal and Endothelial Cell Activation. Eur Heart J. 35:448-54, 2014 PMID: 24265434; PubMed Central PMCID: PMC3924182.

Ganda A, Onat D, Demmer RT, Wan E, Sabbah HN, Colombo PC. Venous Congestion and Endothelial Cell Activation in Acute Decompensated Heart Failure. Curr Heart Fail Rep 7:66-74, 2010. PMID: 20424989; PubMed Central PMCID: PMC3874714.

2) Myocardial recovery during LVAD support. Mechanical volume and pressure unloading induced by LVADs allows a reversal of stress-related compensatory responses leading to full cardiac recovery and device removal in few selected patients. Dr. Colombo's research team has provided the first evidence that myocardial recovery during LVAD support is a spectrum of improvement rather than a binary clinical endpoint, being partial recovery much more frequent than full recovery. These results raised the possibility that patients who achieved only partial recovery may be further improved to complete recovery if treated aggressively with reverse remodeling therapy.

Pan S, Aksut B, Wever-Pinzon OE, Rao SD, Levin AP, Garan AR, Fried JA, Takeda K, Hiroo T, Yuzefpolskaya M, Uriel N, Jorde UP, Mancini DM, Naka Y, Colombo PC, Topkara VK. Incidence and predictors of myocardial recovery on long-term left ventricular assist device support: Results from the united network for organ sharing database. J Heart Lung Transplant. 34:1624-9, 2015 PMID: 26442678.

Topkara VK, Garan AR, Fine B, Godier-Furnémont AF, Breskin A, Cagliostro B, Yuzefpolskaya M, Takeda K, Takayama H, Mancini DM, Naka Y, Colombo PC. Myocardial Recovery in Patients Receiving Contemporary Left Ventricular Assist Devices: Results From the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Circ Heart Fail. 9(7), 2016 PMID: 27402861

3) The hemodynamic and metabolic corrections that occur in the cardiovascular system after LVAD placement.   LVAD therapy has revolutionized the treatment of patients with advanced heart failure and my research has focused on defining clinical and pathophysiologic parameters of LVAD function, the hemodynamic and metabolic response to LVAD placement and the specific determinants of clinical outcomes in this patient population.

Uriel N, Gonzalez-Costello J, Mignatti A, Morrison KA1, Nahumi N, Colombo PC, Jorde UP. Adrenergic activation, fuel substrate availability, and insulin resistance in patients with congestive heart failure. JACC Heart Fail.1:331-7, 2013. PMID: 24621937; PubMed Central PMCID: PMC4495858.

Zile MR, Colombo PC, Mehra M, Greenberg B, Brown S, Konstam MA. Progressive Improvement in Cardiac Performance With Continuous Aortic Flow Augmentation (Aortic Flow Therapy) in Patients Hospitalized with Severe Heart Failure: Results of the Multi-center Trial of the Orqis Medical Cancion System for the Enhanced Treatment of Heart Failure Unresponsive to Medical Therapy. J Heart Lung Transpl 29:86-92, 2010. PMID: 20123246.

Lanier G, Orlanes K, Hayashi Y, Murphy J, Flannery M, Te-Frey R, Uriel U, Yuzefpolskaya M,  Mancini DM, Naka Y, Takayama H, Jorde UP, Demmer RT, Colombo PC. Validity and Reliability of a Novel Slow Cuff-Deflation System for Non-Invasive Blood Pressure Monitoring in Patients with Continuous-Flow Left Ventricular Assist Device. Circ Heart Fail 6:1005-12, 2013. PMID: 23811966.

Mancini DM, Colombo PC. Left Ventricular Assist Devices: A Rapidly Evolving Alternative to Transplant. J Am Coll Cardiol. 65:2542-2555, 2015. PMID: 26065994

Publications: 
Colombo PC, Ashton AW, Celaj S, Talreja A, Banchs JE, DuBois NB, Marinaccio M, Malla S, Lachmann J, Ware JA, Le Jemtel TH. Biopsy Coupled to Quantitative Immunofluorescence: a New Method to Study the Human Vascular Endothelium. J Appl Physiol 92:1331-8, 2002
Colombo PC, Banchs JE, Lachmann J, Malla S, Celaj S, Nicholas B. DuBois NB, Talreja A, Ashton AW, Jorde UP, Ware JA, Le Jemtel TH. Vascular Endothelial Cell Activation in Patients With Decompensated Heart Failure. Response to Short-Term Inotropic Therapy. Circulation 111:58-62, 2005
Onat D, Jelic J, Schmidt AM , Pile-Spellman J, Homma S, Padeletti M, Jin Z, Le Jemtel TH,  Colombo PC* & Feng L* (*Senior Authors). Vascular Endothelial Sampling and Analysis of Gene Transcripts: a New Quantitative Approach to Monitor Vascular Inflammation. J Applied Physiol 103:1873-8, 2007
Vittorio T,   Zolty R, Parveen K, Garg PK, Sarswat N, Tseng CH, , Jorde UP, Colombo PC.  Interdependence of Cardiac and Endothelial Function in Patients with Chronic Heart Failure on Optimal Medical Therapy. Echocardiography 26:916-21,2009
Dini FL, Demmer RT, Simionuc A , Donati F, Dell’Anna R, Orsini E, Caravelli P, Marzilli M, Colombo PC. Right Ventricular Function Predicts Chronic Kidney Disease and Survival in Patients With Chronic Systolic Heart Failure. Eur J Heart Fail 14:287-94, 2012
About: 

Paolo C. Colombo is a cardiologist who specialized in treating patients with heart failure, cardiac assist device and heart transplant. Dr. Colombo is board certified in Cardiovascular Disease and in Advanced Heart Failure and Transplant Cardiology.

Dr. Colombo received his medical degree, magna cum laude from the University of Milan in Italy. He completed his internal medicine residency and fellowship at Montefiore Medical Center, the university hospital for the Albert Einstein College of Medicine in New York. He then specialized in heart failure and transplant at NewYork-Presbyterian Hospital/Columbia University Medical Center in New York.

Dr. Colombo has been on ColumbiaDoctors faculty since 2002. He is the Sudhir Choudhrie Associate Professor of Cardiology and serves as the Director of the Center for Advanced Cardiac: Heart Failure, Heart Transplant and Mechanical Circulatory Support.

An internationally renowned investigator, Dr. Colombo has been awarded research grants from the National Institutes of Health, American Heart Association as well as other research foundations. Dr. Colombo has published more than 90 manuscripts and presented his research all over the world.

Dr. Colombo sees patients at Columbia University Medical Center in Washington Heights.