Prospective and retrospective data collection. This protocol establishes a registry and a tissue bank, but does not dictate treatment or intervention. The objective of this investigation is to develop a comprehensive endocrine tumor tissue bank linked to a patient-level clinical history database, and to perform research on these tissues and data in order to determine factors that influence tumor growth, metastatic propensity, and prognosis of patients with endocrine tumors (thyroid, parathyroid, adrenal, and paraganglioma).

Primary hyperparathyroidism (PHPT) is a condition characterized by overactivity of the parathyroid glands leading to elevated parathyroid hormone and blood calcium levels. Other affected organs include the skeleton (calcium loss leads to a "weakening" of the skeleton), and the kidneys (high blood calcium can lead to kidney stones). Many patients with mild PHPT also have low levels of vitamin D. Both PHPT and Vitamin D Deficiency weaken the skeleton. Recent medical guidelines recommend treating patients with PHPT and low Vitamin D levels with Vitamin D.