Researcher’s Profile

Helen E. Remotti, MD


I joined the division of Surgical Pathology in the Department of Pathology and Cell Biology at Columbia University as a faculty member in 2002. One of my primary functions as a surgical pathologist at Columbia University involves providing diagnostic expertise in diverse areas of pathology from clinical cases with a high level of complexity. I serve as a senior consultant pathologist, with a focused interest in pancreatic, hepatic and gastrointestinal pathology. At Columbia University this subspecialty includes a wide spectrum of diagnostically challenging cases encompassing transplant pathology (liver, small intestine, pancreas), adult and pediatric medical liver disease, and oncologic pathology.

As a member in the division of Personalized Genomics as of 2016, I have been involved in molecular profiling studies examining a variety of types of pediatric hepatobiliary and gastrointestinal tumors. Since 2014, I have been involved in the Precision in Pediatrics (PIPseq) Cancer initiative, and have been working closely with members in the Division of Pediatric Hematology/ Oncology, primarily focusing on molecular studies involving pediatric liver tumors and neuroblastomas. Due to the expertise of our liver surgeons and orthotopic liver transplantation program, and our pediatric oncologists we see an over representation of high risk pediatric hepatic tumors. In collaboration with the Herbert Irving Cancer Center Tumor bank, for these studies we have an established a hepatic tumor pathology database with tissue microarrays and examined a variety of immunohistochemical and molecular biomarkers in subsets of these tumors. These studies may offer patients the possibility of entry into clinical trials that will enable the use of novel targeted drug therapies, particularly in classes of tumors unresponsive to conventional treatment modalities.