Phase I Window of Opportunity Study of Parasympathetic Stimulation with Bethanechol in Localized Pancreatic Adenocarcinoma Prior to Surgery

Are you Eligible? (Inclusion Criteria)

Inclusion Criteria:

  • ECOG performance status of 0 or 1
  • Histologically or cytologically confirmed diagnosis of resectable pancreatic ductal adenocarcinoma or be willing to undergo a biopsy with confirmed pathology prior to starting therapy

Exclusion Criteria:

  • Evidence of bacteriuria on U/A within 7 days of study registration
  • Currently using an acetylcholinesterase inhibitor or beta blocker
  • Active peptic ulcer disease
  • Uncontrolled hyperthyroidism¬†
  • Bradycardia resting HR <55 BPM
  • Chronic hypotension with resting BP <90mmHg. 6. CAD within 5 years prior to study entry
  • Seizure disorder
  • Latent or active bronchial asthma

Specialty Area(s)