Gulam A. Manji, MD, PhD
Director of Gastrointestinal Oncology
Director of Pancreas Translational Research
Co-Director of The Pancreas Center
Call
(212) 305-5098
for appointments.
About Gulam A. Manji, MD, PhD:
Gulam A. Manji, MD, PhD, is an Associate Professor of Medicine at Columbia University Irving Medical Center, Director of Gastrointestinal Medical Oncology, Co-Director of The Pancreas Center, and co-leader of the Precision Oncology and Systems Biology Program at the Herbert Irving Comprehensive Cancer Center. He completed residency in internal medicine at Albany Medical College and fellowship in Hematology/Oncology at New York-Presbyterian/Columbia.
Dr. Manji is a physician-scientist focused on developing new therapeutic strategies for gastrointestinal malignancies, particularly pancreatic ductal adenocarcinoma. His translational research bridges tumor immune microenvironment biology, stromal signaling, KRAS/RAS pathway targeting, CXCR4-CXCL12 biology, autophagy and MAPK signaling, adenosine-mediated immunosuppression, and biomarker-driven clinical trial development.
A major focus of his work has been the CXCR4-CXCL12 pathway in pancreatic cancer. Building on preclinical studies showing that CXCR4 inhibition can remodel the pancreatic tumor microenvironment and enhance antitumor immunity, Dr. Manji advanced this work from bench to bedside through an investigator-initiated clinical trial combining chemotherapy, CXCR4 inhibition, and immune checkpoint blockade. The pilot study demonstrated impressive tumor shrinkage, including one pathologic complete response among 11 patients, and was published in Nature Communications in 2026. These findings supported expansion into a multicenter randomized phase 2 trial that is currently enrolling patients.
Dr. Manji has also contributed to major advances in RAS-directed therapy for pancreatic cancer. He was a co-contributor to the Nature publication evaluating RMC-7977, a RAS-GTP inhibitor tool compound, in preclinical pancreatic cancer models, helping establish the rationale for broad-spectrum RAS inhibition in pancreatic cancer. He also played a role in the positive phase 3 daraxonrasib clinical trial in previously treated metastatic pancreatic cancer, which demonstrated significant improvements in progression-free and overall survival and was published in The New England Journal of Medicine.
Clinically, Dr. Manji cares for patients with pancreatic, hepatobiliary, colorectal, and upper gastrointestinal cancers. His overarching goal is to bring rational, biomarker-informed therapeutic combinations from the laboratory to the clinic to improve outcomes for patients with pancreatic and other gastrointestinal malignancies.
Recent publications: manji ga - Search Results - PubMed
To donate to the Manji Research Gift Fund: https://medicine.givenow.columbia.edu/
Expertise:
Clinical Research Trials
Colon Cancer
Colon and Rectal Cancer
Colorectal Cancer
Gallbladder Cancer
Gastrointestinal Malignancies
Gastrointestinal Malignancy
Hematology/Oncology
Internal Medicine
Liver Cancer
Liver Lesions
Liver Masses
Liver Tumors
Medical Oncology
Pancreas Cancer
Pancreatic Cancer
Pancreatic Cyst
Pancreatic Tumor
Rectal Cancer
Stomach Cancer
Appointments:
Assistant Professor of Medicine at CUMC
Education:
Medical School: Ross University School of Medicine
Medical School: University of Wisconsin
Residency: Albany Medical Center
Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
New Patients:
YES
Locations
Primary Locations:
CUIMC/Herbert Irving Pavilion
161 Fort Washington Avenue
New York, NY 10032
- For new patient appointments, call:
- (212) 305-5098
- Fax:
- (646) 317-6340
Insurances:
Please contact the doctor's office directly to verify that your particular insurance is accepted.
AETNA [Aetna Signature Administrators, Medicare Managed Care, HMO, PPO, POS, EPO, NY Signature, Student Health]
Affinity Health Plan [Essential Plan, Medicaid Managed Care]
Amida Care [Special Needs]
CIGNA [PPO, HMO, Great West (National), EPO, POS]
ElderServe [Special Needs]
Emblem/GHI [PPO, Medicare Managed Care]
Emblem/HIP [Select Care (Exchange), Vytra, EPO, Medicare Managed Care, HMO, PPO, POS, ConnectiCare, Essential Plan, Medicaid Managed Care]
Empire Blue Cross Blue Shield HealthPlus [Medicaid Managed Care, Child/Family Health Plus, Essential Plan, Individual Network (Exchange)]
Empire Blue Cross/Blue Shield [PPO, Medicare Managed Care, HMO, EPO]
Fidelis Care [Essential Plan, Medicaid Managed Care, Medicare Managed Care, Child/Family Health Plus]
Healthfirst [Leaf (Exchange), Medicaid Managed Care, Child/Family Health Plus, Medicare Managed Care]
Healthspring (Cigna Medicare) [Medicare Managed Care]
Local 1199 [Local 1199]
MVP Health Care [HMO, Essential Plan, Child/Family Health Plus, Medicaid Managed Care]
MagnaCare (National) [MagnaCare]
Medicare [Traditional Medicare, Railroad]
Multiplan [Multiplan]
UnitedHealthcare [HMO, POS, PPO, Empire Plan, Oxford Liberty, Oxford Freedom, Oxford HMO, Medicare Managed Care, Medicaid (Community Plan)]
VNSNY CHOICE [SelectHealth, Medicare Managed Care, Special Needs]
WellCare [Medicaid Managed Care, Medicare Managed Care]
World Trade Center Health Plan [World Trade Center Health Plan]