Physician’s Profile

Isaac George, MD

Surgical Director of the Heart Valve Center at Columbia
Director Hybrid Coronary Interventions, New York, NY
Associate Professor of Surgery
Affiliations: 
NewYork-Presbyterian/Columbia
Board Certificates: 
Cardiothoracic Surgery
Surgery
Expertise: 
Aortic Dissection
Aortic Disease
Aortic Aneurysm With Dissection
Aortic Surgery
Aortic Stent Grafts
Aortic Stenosis
Heart Valve Surgery
Robotic Surgery
Mitral Valve Reconstruction
Aortic and Mitral Valve Surgery
Valve Replacement
Aortic Aneurysm
High Risk Surgery of the Elderly
Aortic Arch Surgery
Mitral Valve Replacement/Repair
Heart Disease
Heart Surgery
Heart Disease and Women
Valvular Heart Disease
Heart Valve Replacement
Heart Valve Disease
Mitral Valve Surgery
Atrial Fibrillation, Surgical Treatment
Coronary Artery and Valvular Disease
Heart Transplantation
Minimally Invasive Aneurysm Repair
TAVR (Transcatheter Aortic Valve Replacement)
Marfan's Syndrome
Heart Failure
Aortic Aneurysm Repair
Heart Valve Repair
Mitral/Aortic Valve Replacement
Coronary Artery Bypass Surgery (Off Pump)
Valve Reconstruction/Repair
Percutaneous Valve Interventions
Aortic Valve Surgery
Aortic Aneurysm Surgery
Minimally Invasive Heart Surgery
Bloodless Surgery
Minimally Invasive Valve Repair
Thoracic Aneurysm Repair
Open Heart Surgery
Mitral Valve Repair
Pericardial Disease
Off Pump Coronary Bypass Surgery
Honors: 

1993 – Duke University Comprehensive Cancer Center Fellowship

1995 – Pi Tau Sigma, Mechanical Engineering Honor Society

2004 – New Era Cardiac Surgery Conference Scholarship

2006 – Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons

2007 Blakemore Award – Best Resident Research Award, Columbia University College of Physicians and Surgeons

2008 Blakemore Prize – Best Resident Research Award, Columbia University College of Physicians and Surgeons

Interests: 
Regulation of myostatin signaling in human cardiomyopathy
TGFB regulation in non-syndromic aortic aneurysm formation.
Valve interstitial cell activation mechanisms after surgical and transcatheter valve replacement.
Clinical outcomes after valve and hybrid surgery.
Cardiomyopathy
Aortic aneurysm formation
Surgical and transcatheter valve replacement
About: 

Dr. Isaac George, MD joined NewYork Presbyterian/Columbia University Medical Center in the Department of Surgery in July of 2001 as a resident in general surgery following his graduation from Duke University School of Medicine. Prior to receiving his MD, Dr. George completed a B.S. in Mechanical Engineering at Massachusetts Institute of Technology in 1997. Dr. George also completed a fellowship program in cardiothoracic surgery in 2011 as well as a fellowship program in interventional cardiology in 2012. In July, 2012 Dr. George became an Assistant Professor of Surgery and later an Assistant Professor of Medicine. In 2019, Dr. George was promoted to Associate Professor of Surgery.

Dr. George is board certified in thoracic surgery and general surgery. He performs all types of open complex adult cardiac surgery (aortic, mitral and tricuspid valve surgery, aortic aneurysm surgery, coronary bypass grafting, robotic surgery) and specializes in complex valvular and aortic disease. He annually performs 200+ open heart surgeries a year and is one of the few physicians in the world trained in both cardiac surgery and interventional cardiology. Dr. George is currently the Surgical Director of the Structural Heart and Valve Center at Columbia University Medical Center. His surgical outcomes remain some of the best in the state despite taking on the highest risk cases (surgical mortality rate by year: 2013: 3.5%, 2014: 2.5%, 2015: 4%, 2016: 2.5%, 2017: 1.5% 2018: 1.5%).

Dr. George is focused on integrating new technology and innovation into his clinical practice. He is trained in the most current and cutting-edge procedures including Transcatheter Valve Replacement (TAVR, TMVR), transcatheter valvular repair, percutaneous coronary stenting, and aortic stent grafting. He performs almost 500 transcatheter valve procedures a year, in addition to his busy open surgical practice and has personally done almost 3000 TAVR procedures. Because he is trained in multiple disciplines, he is able to combine strategies to create a treatment plan for each individual patient that is both unbiased and personalized. As Primary Investigator of a national TAVR trial and with involvement in numerous other clinical trials, he has extensive clinical research trial experience. 

Dr. George is involved in both benchtop and clinical research as well. His primary scientific goals involve the regulatory mechanisms of myostatin (a negative regulator of muscle growth) to insulin-like growth factor-1 and its role in cardiac hypertrophy and cardiomyopathy. Specifically, his group is the first to report the importance of myostatin activation in heart failure. As director of the cardiac surgery research laboratory, he oversees surgical fellows, post-doctoral students, masters students, and research assistants in both scientific projects and clinical outcomes in cardiac surgery and TAVR. His projects reflect the translational nature of the lab as well as his clinical interests. His clinical practice allows him to be uniquely positioned to advance this research with a clinical endpoint and potential therapeutic intervention as the goal.

Watch: Meet Cardiothoracic Surgeon, Dr. Isaac George

Watch: Dr. Isaac George Discusses Advancements in Heart Valve Surgery

Dr. George hosts Taking it to Heart, the Columbia Heart Valve team's podcast. In each episode, Dr. George and the Columbia Heart Valve team discuss a new topic related to valvuar disease. Subscribe to Taking It to Heart.

Click here for a full list and description of ongoing trials from Dr. George.

Publications: 
Castillero E, Akashi H, Najjar M, Ji R, Wang C, Liao X, Zhang X, Sperry A, Gailes M, Guaman K, Retch A, Schlosberg I, Sweeney HL, Ali ZA, Homma S, Ferrari G, Colombo PC, Schultze PC, George I.  Myostatin Inhibition After Experimental Heart Failure Improves Cardiac Function and Remodeling. (submitted)
Kassar M, Khalique O, Pilgrim T, Carrel T, Windecker S, George I, Praz F.  Open Transatrial Implantation of Transcatheter Heart Valve For Mitral Disease. (submitted)
Guerrero M, Vemulapalli S, Xiang K, Wang DD, Eleid M, Cabalka AK, Sandhu G, Salinger M, Russell H, Greenbaum A, Kodali S, George I, Dvir D, Whisenant N, Russo MJ, Pershad A, Fang K, Coylewright M, Shah P, Babaliaros V, Khan J, Lederman R, Tommaso C, Saucedo J, Kar S, Makkar R, Mack M, Holmes D, Nishimura RA, Leon M, Bapat V, Thourani V, Rihal C, O’Neill W, Feldman T.  30-Day Outcomes of Transcatheter Mitral Valve Replacement for Degenerated Mitral Bioprostheses (Valve-in-Valve), Failed Surgical Rings (Valve-in-Ring), and Native Valve with Severe Mitral Annular Calcification (Valve-in-MAC) in the United States: Data from the STS/ACC/TVT Registry.  (submitted)
Kennel PJ, Liao X, Saha A, Ji R, Zhang X, Castillero E, Brunjes DL, Takayama H, Naka Y, Thomas T, George I, Mancini D, Schulze PC.  Suppression of the Amino Acid Carrier SLC1A5 in Failing Myocardium Results in Decreased Glutamine Levels and Induction of Autophagy.  (submitted)
Castillero E, Akashi H, Najjar M, Wang C, Zhang X, Liao X, Gailes M, Schlosberg I, Guaman K, Sweeney HL, Ali ZA, Homma S, Ferrari G, Colombo PC, Schulze PC, George I.  Myostatin Inhibition After Experimental Heart Failure Improves Cardiac Function and Remodeling.  (submitted)
Velagupudi P, Turagam MK, Kolte D, Khera S, Gupta T, Abbott JD, George I, Khalique O, Vahl T, Nazif T, Kodali S, Sommer R.  Intracardiac Versus Transesophageal Echocardiography for Percutaneous Left Atrial Appendage Occlusion: A Meta-Analysis.  (accepted-J Cardiovasc Electrophys)
Sondergaard L, Popma J, Reardon M, Van Miegham NM, Deeb MG, Kodali S, George I, Williams M, Yakubov S, Kappetein AP, Serruys PW, Grube E, Schiltgen M, Chang Y, Engstrom.  Comparison of a complete percutaneous versus surgical approach to aortic valve replacement and revascularization in patients at intermediate surgical risk: results from the randomized SURTAVI trial.  (submitted)
Nguyen TC, Nguyen S, Forcillo J, George I, Kaneko T, Thourani V, Bavaria J, Mack MJ, Cheung A, Reardon MJ, Tang GH. The Train has left: Can surgeons still get a ticket to treat structural heart disease?  (accepted-J Thorac Cardiovasc Surg)
Moore S, Chau KH, Chaudhary S, Rubin G, Bayne J, Avula MR, Wang DY, Sorbera C, Dizon J, Biviano A, Waase M, Iyer V, George I, Kodali SK, Nazif TM, Garan H, Wan E.  Leadless Pacemaker Implantation Post-Transcatheter Heart Valve.  (accepted-PACE)
Shea NJ, Bethancourt CN, Polanco AR, Sanchez J, George I, Patel V, Takayama H.  Improving Outcomes of Iatrogenic Type A Aortic Dissection during Cardiac Surgery.  (submitted)
Kossar AP, Borger M, George I.  Direct Access Valve-in-Valve Implantation for Management of Complex Valvulopathy.  (accepted-Cardiovasc Cath Int)
Hahn RT, George I, Kodali SK, Nazif T, Khalique O, Akkoz D, Kantor A, Vahl T, Patel A, Elias E, Ng V, Spina R, Bartus K, Valegapudi P, Wu I, Leon M, Bapat V.  Early Single-Site Experience with Transcatheter Tricuspid Valve Replacement.  (accepted-JACC Imaging)
Nazif TM, Chen S, George I, Dizon JM, Hahn RT, Crowley A, Alu MC, Babaliaros V, Thourani VH, Hermann HC, Smalling RC, Brown DL, Mack MJ, Kapadia S, Makkar R, Webb JG, Leon MB, Kodali SK.  Adverse Clinical Implications of New-Onset Left Bundle Branch Block after TAVR: An Analysis of Intermediate Risk Patients from the PARTNER II Trial and Registry.  (accepted-Eur Heart J)
Hahn RT, Nabauer, M, Zuber M, Nazif T, Hausleiter J, Pozzoli A, Taramasso M, George I, Kodali S, Bapay V, Maisano F.  Procedural Imaging of Transcatheter Tricuspid Interventions (accepted-JACC Cardiovasc Imaging)
Taramasso M, Pozzoli A, Dreyfus, G, Bolling S, George I, Zuber M, Maisano F.  Tricuspid regurgitation: Predicting the need for intervention, procedural success, and recurrence of disease. (accepted-JACC Cardiovasc Imaging)
Lampert J, Finn MT, Kantor A, Akkoc D, Chen S, Brandwein R, Fidlow K, Liao M, Khalique O, Hahn RT, Vahl TP, George I, Kirtane A, Leon MB, Kodali S, Nazif TM.  Complications of Indwelling Urinary Catheters in Patients Undergoing Transcatheter Aortic Valve Replacement. (submitted)
Duncan A, Moat N, Simonato M, Weger Ad, Kempfert J, Eggebrecht H, Walton A, Hellig F, Kornowski R, Spargias K, Mendiz O, Makkar R, Guerrero M, Rihal C, George I, Don C, Iadanza A, Bapat V, Welsh R, Wijeysundera H, Wolff R, Gafoor S, Nombela-Franco L, Cobiella J, Dvir D.  Periprocedural and Clinical Outcomes Following Transcatheter Aortic Valve Implantation for Degenerative Stentless versus Stented Bioprothesis: Insights from the Valve-in-Valve International (VIVID) Registry.  (submitted-Eur Heart J)
Eudailey K, Olds A, Lewis CT, Nazif TN, Vahl T, Khalique O, Hahn RT, Bapat V, Borger MA, Leon MB, Ahmed MI, Kodali SK, George I.  Contemporary Suprasternal Transcatheter Aortic Valve Replacement: A Multicenter Experience using a simple, reliable alternative access approach.  (submitted-J Thorac Cardiovasc Surg)
Sorabella RA, Olds A, Yerebakan H, Hassan D, Borger MA, Argenziano M, Smith CR, George I.  Is Isolated Aortic Valve Replacement Sufficient to Treat Concomitant Moderate Functional Mitral Regurgitation? A Propensity-Matched Analysis.  (accepted-J Cardiothoracic Surg)
Cheng YT, Leb JS, Bloom M, Melehy AN, Polanco A, George I, Takayama H.  Use of branched aortic graft to facilitate coronary reconstruction at complex aortic surgery. (accepted-Operative Techniques in Thorac and Cardiovasc Surg)
Valenzuela I, Hunter MD, Sundheim K, Klein B, Dunn L, Sorabella R, Han SM, Willey J, George I, Gutierrez J.  Clinical Risk Factors for Acute Ischemic and Hemorrhagic Stroke in Patients with Infective Endocarditis. (accepted-Internal Medicine Journal)
Kobsa S, Sorabella RA, Eudailey K, Lee R, Borger M, Bapat V, George I.  Transatrial Implantation of the Sapien 3 Heart Valve in Severe Mitral Annular Calcification: Multi-Clinic Experience, Written and Video Description.  (accepted-Structural Heart)
Green P, Oberwis BS, Chung CH, George I, Vahl T, Harjai K, Hawkey M, Khalique O, Hahn RT, Williams MR, Kirtane AJ, Leon MB, Kodali SK, Nazif TM.  The “Eyeball Test” for Risk Assessment in Aortic Stenosis: Characterizing Subjective Frailty using Objective Measures. (accepted-Structural Heart J)
Olds A, Eudailey K, Nazif T, Vahl T, Khalique O, Lewis C,  Hahn RT, Leon M, Bapat V, Ahmed M, Kodali SK, George I.  Suprasternal and Left Axillary Transcatheter Aortic Valve Replacement in Morbidly Obese Patients.  (Accepted-Annals Thorac Surg)
Olds A, DeRoo S, Van Boxtel B, Sorabella R, Wang C, Argenziano M, Smith CR, George I.  Diabetes Mellitus Does Not Worsen Long-Term Survival Following Isolated Surgical Aortic Valve Replacement: A Propensity Matched Analysis.  (submitted)
McElhinney DB, Aboulhosn JA, Dvir D, Whisenant B, Eicken A, Ribichini F, Tzifa A, Hainstock MR, Martin MR, Kornowski R, Schubert S, Latib A, Thomson JR, Crittendon I, Torres A, Meadows J, Delaney JW, Guerrero M, Salizzoni S, El-Sai H, Finkelstein A, George I, Gewelling M, Alvarez-Fuente M, Lamers L, Cheema AN, Kreutzer JN, Rudolph T, Hildick-Smith D, Cabalka A.  Mid-Term Valve-Related Outcomes After Transcatheter Tricuspid Valve-in-Valve or Valve-in-Ring Replacement.  (submitted)
Langer NB, Ando M, Simpson M, van Boxtel B, Sorabella RA, Patel V, George I, Smith CR, Takayama H.  Influence of Left Ventricular Ejection Fraction on Early Morbidity and Mortality after Aortic Root Replacement.  (accepted-JTCVS)
Russell H, Guerrero M, Salinger MH, Manzuk MA, Pursnani A, Wang DD, Nemeh H, Sakhuja R, Melnitchouk S, Pershad A, Feng K, Said SM, Kauten J, Tang G, Aldea G, Feldman T, Bapat V, George I.  Open Atrial Transcatheter Mitral Valve Replacement in Patients with Mitral Annular Calcification.  J Am Coll Cardiol  2018;72(13):1437-1448.
Praz F, Khalique OK, Lee R, Wu IY, Veeragandham R, Russell H, Guerrero M, Islam A, Deaton DW, Kaneko T, Eudailey KW, Akkoc DA, Kantor A, Wang CY, Tang DC, Park JS, Leung D, Nazif TM, Vahl T, Hahn RT, Kodali SK, Leon MB, Takayama H, Bapat V, Borger MA, George I.  Imaging in Patients with Severe Mitral Annular Calcificiation: Insights From a Multicenter Experience Using Transatrial Balloon-Expandable Valve Replacement.  (accepted – Eur Heart J Cardiovasc Imaging)
Guerrero M, Urena M, Himbert D, Wang DD, Eleid M, Kodali S, George I, et al.  1-Year Outcomes of Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease with Severe Mitral Annular Calcification: Update from the First Multicenter Global Registry.  (accepted-JACC Int)
Chen S, Redfors B, Ben-Yehuda O, Crowley A, Dvir D, Hahn RT, Pibarot P, Jaber W, Webb JG, Yoon SH, Makker RJ, Alu MC, Thourani VH, Tuzcu EM, Mack MJ, George I, Nazif T, Kodali SK, Leon MB. Outcomes of Patients with Significant Obesity Undergoing TAVR or SAVR in the Randomized PARTNER 2 Trial. (accepted-Structural Heart J)
Van Boxtell B, Yerebakan H, Olds A, DeRoo S, Hassan D, Patel S, Kantor A, Leung D, Wang C, Kurlansky P, Borger M, Argenziano M, Smith C. George I.  Uncorrected Moderate Tricuspid Regurgitation Does Not Worsen Outcomes after Surgical Aortic Valve Replacement.  (submitted)
Castillero E, Ali ZA, Akashi H, Giangreco N, Wang C, Ji R, Zhang X, Kheysin N, Park JS, Hegde S, Patel S, Stein S, Cuenca C, Leung D, Homma S, Tatonetti N, Topkara V, Takeda K, Colombo PC, Naka Y, Sweeney HL, Schulze PC, George I.  Structural and Functional Cardiac Profile after Prolonged Duration of Mechanical Unloading: Potential Implications for Myocardial Recovery. Am J Phys-Heart Circ Physiol 2018;315(5):H1463-H1476.
Praz F, Khalique OK, Macedo LG, Jantz J, Yu IY, Patel A, Vahl T, Bapat V, George I, Nazif T, Kodali SK, Leon MB, Hahn RT.  Comparison Between Three-Dimensional Echocardiography and Computed Tomography for Tricuspid Valve Assessment: Implications for Tricuspid Regurgitation Grading and Transcatheter Therapies.  J Am Soc Echocardiogr  2018;31(11): 1190-1202.
Praz F, Khalique O, Lee R, Veeragandham R, Hyde R, Guerrero M, Islam A, Deaton DW, Kaneko Y, Kodali SK, Leon MB, Bapat V, Takayama H, Borger MA, George I.  Transatrial Implantation of the Sapien Transcatheter Heart Valve for the Treatment of Severe Mitral Annular Calcification: A MultiCenter Experience.  J Thorac Cardiovasc Surg 2018;156(1): 132-142.
Pulerwitz TC, Khalique OK, Leb J, Kodali SK, Hahn RT, Nazif TM, Leon MB, George I, Vahl TP, Dumeer S, D’Souza B, Einstein AJ.  Optimizing Cardiac Computed Tomography Protocols for Comprehensive Acquisition Prior to Percutaneous Mitral and Tricuspid Valve Repair/Replacement: A Practical How-to Guide.  (accepted-JACC Cardiovasc Imaging)
Gancayo JA, Liqiong F, Langer N, van Boxtell B, Sorabella R, Wang C, Park JE, Wu Y, Cuenca C, Smith CR, Borger MA, Argenziano M, Basur O, Kurlansky P, George I.  Readmission after Mitral Valve Surgery for Functional Mitral Regurgitation: Detailed Insights in Heart Failure Recurrence and Healthcare Utilization.  (submitted)
Bleiziffer S, Erlebach M, Simonato M, Pibarot P, Webb J, Capek J, WIndecker S, George I, Sinning JM, Horlick E, Napodano M, Holzhey D, Petursson P, Cerillo A, Bonaros N, Ferrari E, Cohen M, Baquero G, Jones T, Kalra A, Reardon M, Chatriwalla A, Ribeiro VG, Alnasser S, van Meighem N, Rustenbach C, Schofer J, Garcia S, Zeus T, Champagnac D, Bekeredjian R, Kornowski R, Lange R, Dvir D.  Residual Stenosis after Aortic Valve-in-Valve Procedures: Incidence, Predictors, and Clinical Outcomes.  Heart 2018;104(10):828-834.
Baron SJ, Thourani VH, Kodali S, Arnold SV, Wang K, Magnuson EA, Pichard AD, Babaliaros V, George I, Miller DC, Tuzcu M, Greason K, Herrman HC, Smith CR, Leon MB, Cohen DJ.  Effect of Sapien-3 Transcatheter Valve Implantation on Health Status in Patients with Severe Aortic Stenosis at Intermediate Surgical Risk: Results from the PARTNER S3i Trial.  JACC Cardiovasc Intervent 2018:11(12):1188-1198.
Codner P, Malick W, Kouz R, Patel A, Chen CH, Terre J, Vahl TP, George I, Nazif T, Kirtane A, Khalique O, Hahn RT, Leon M, Kodali S. Mortality Risk Assessment After Transcatheter Aortic Valve Replacement: A Comparative Analysis of the Predictive Accuracy of the Transcatheter Valve Therapy Registry Risk Assessment Model.  Eurointervention 2018;14(4):e405-e412.
Esquitin K, Khalique O, Kodali SK, Marcoff L, Nazif TM, George I, Vahl TP, Leon MB, Hahn RT.  Accuracy of the Single Cycle Length Method for Calculation of Effective Orifice Area in Irregular Heart Rhythms. (accepted - J Am Soc Echocardiography)
Han SM, Sorabella R, Vasan V, Grbic M, Yerebakan H, Lambert D, Prasad R, Castillero E, Takayama H, Kurlansky P, Borger M, Gordon R, George I.  Influence of Staphylococcus Aureus on Outcomes after Valvular Surgery for Infective Endocarditis.  J Cardiothorac Surg 2017;12(1):57-62.
Transcatheter Mitral Valve Replacement for Patients with Symptomatic Mitral Regurgitation: A Global Feasibility Trial.  J Am Coll Cardiol 2017;69(4):381-391.
Santana O, Singla S, Milhos CG, Pineda AM, Stone GW, Kurlansky PA, George I, Kirtane AJ, Smith CR, Beohar N.  Outcomes of a Combined Approach of Percutaneous Coronary Revascularization and Cardiac Valve Surgery.  Innovations 2017;12(1):4-8.
Hamid N, Khalique OK, Nazif TM, Vahl T, George I, Kodali SK, Leon MB, Hahn RT.  Flow Characteristics of the Self-Expanding Transcatheter Aortic Valve Relevant to Accurate Calculation of Effective Orifice Area. (submitted)
Forrest JK, Mangi AA, Popma JJ, Khabbaz K, Reardon MJ, Kleiman NS, Yakubov SJ, Watson D, Kodali SK, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Qiao H, Oh JK, Williams MR.  Early Outcomes with the Evolut PRO Repositionable Self-Expanding Transcatheter Aortic Valve with Pericardial Wrap.  JACC Cardiovasc Int 2018:11(2):160-168.
Bettinger N, Khalique OK, Krepp JM, Hamid NB, Bae DJ, Pulerwitz TC, Liao M, Hahn RT, Vahl TP, Nazif T, George I, Leon MB, Einstein AJ, Kodali SK.  Practical determination of aortic valve calcium volume score on contrast-enhannced computed tomography prior to transcatheter aortic valve replacement and impact on paravalvular regurgitation: Elucidating optimal threshold cutoffs.  J Cardiovasc Comput Tomogr 2017;11(4):302-308.
Malasrie SC, Hodson RW, McAndrew TC, Davidson C, Swanson J, Hahn RT, Pibarot P, Jaber WA, Quader N, Zajarias A, Svensson L, George I, Trento A, Thourani V, Szeto WY, Dewey T, Smith CR, Leon MB, Webb JG.  Outcomes after transcatheter and surgical aortic valve replacement in intermediate risk patients with preoperative mitral regurgitation: Analysis of PARTNER II randomized cohort.  Structural Heart 2018;2(4): 336-343.
Song J, Ascherman B, Eudailey K, Mohar M, Argenziano M, Takayama H, George I.  Long-term Failure of Amplatzer Plugs in the Treatment of Aortic Pathology. J Card Surg 2017;32(7):426-429.
Codner P, Pulgiese D, Kouz R, Patel A, Chen CH, Terre J, Eudailey K, Nazif T, Vahl T, George I, Khalique O, Hahn R, Leon MB, Kodali S, Borger M. Transcatheter Aortic Valve Replacement via a Novel Suprasternal Approach.  Ann Thoracic Surg 2017;105(4): 1215-1222.
Williams MR, Reardon MJ, Manoharan G, Walton A, Harrison K, Hughes GC, Kodali SK, George I, Deeb M, Chetcuti S, Qiao H, Khabbaz K, Popma JJ.  Transcatheter Aortic Valve Replacement with a Repositionable Self-Expanding Bioprosthesis: One-Year Pooled Results from the Evolut R Programs. 
Kennel P, Saha Am Maldonado DA, Givens R, Brunjes DL, Castillero E, Zhang X, Ji R, George I, Mancini DM, Koller A, Zorn E, Colombo P, Chen EI, Schulze PC.  Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection.  J Heart Lung Transplant 2017;S1053-2498(17):31903-4.
George I, Guglielmetti LC, Bettinger N, Moss A, Wang C, Keysin N, Hahn R, Kodali S, Leon M, Bapat M, Borger MA, Williams M, Smith C, Khalique OK.  Aortic Valve Annular Sizing: Intraoperative Assessment Versus Preoperative Multidetector Computed Tomography. Circ Cardiovasc Imaging 2017;10(5):pii.eoo5968.
Paradis JM, White J, Genereux P, Urena M, Doshi D, Nazif T, Hahn R, George I, Khalique O, Harjai K, Lasalle L, Labbe BM, DeLarochelliere R, Doyle D, Dumont E, Mohammadi S, Leon MB, Rodes-Cabau J, Kodali SK.  Impact of Coronary Artery Disease Severity Assessed with the SYNTX Score on Outcomes Following Transcatheter Aortic Valve Replacement.  JAHA 2017;6:e005070-7.
Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George I, Takayama H, Naka Y, Goldberg IJ, Schulze PC.  Increased de novo ceramid synthesis and accumulation of ceramides in failing myocardium.  JCI Insight 2017;2(14):pii96203-9.
Castano A, Narotsky D, Morgenstern R, Hamid N, Khalique OK, Rubin J, Chiuzan C, Nazif T, Vahl T, George I, Kodali S, Leon MB, Hahn RT, Bokhari S, Maurer MS.  Unveiling Transthyretin Cardiac Amyloidosis and its Predictors Among Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. Eur Heart J  2017;38(36):2879-2887.
Zhang X, Ji R, Liao X, Castillero E, Kennel PJ, Brunjes D, Drosatos K, George I, Chen E, Schulze PC.  miR-195 Regulates Myocardial Metabolism in Heart Failure via Alterations in SIRT3 Expression and Mitochondrial Proteins Acetylation Profile.  (Accepted-Circulation)
Salna M, Khalique OK, Chiuzan C, Nazif T, Vahl T, Patel A, Wu Y, Kurlansky P, Borger M, Hahn RT, Leon MB, Smith CR, Kodali SK, George I.  Impact of Small Prosthesis Size on Patients undergoing Transcatheter or Surgical Aortic Valve Replacement.  Cardiovasc Catheter Interventions 2017:doi 10.1002/ccd.27120.
Popma JJ, Reardon MJ, Khabbaz K, Harrison KJ, Hughes CG, Kodali SK, George I, Deeb M, Chetcuti S, Kipperman R, Brown J, Qiao H, Slater J, Williams MR.  Early Clinical Outcomes After Transcatheter Aortic Valve Replacement Using a Novel Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis Suboptimal for Surgery: Results of the Evolut R Study.  JACC Cardiovasc Interv  2017;10(3):268-275.
Khalique O, Hamid N, White J, Bae DJ, Kodali SK, Nazif TM, Vahl T, Paradis JM, George I, Leon MB, Hahn RT.  Impact of Methodological Differences in 3-Dimensional Echocardiographic Measurements of the Aortic Annulus Compared to Computed Tomography Angiography Before Transcatheter Aortic Valve Replacement.  J Am Soc Echocardiography 2016;10:1016-8.
Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AVB, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.  Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.  Am J Trans Res 2017;9(6):2723-2735.
Coromilas E, Que-Xu E, Moore D, Kato T, Wu C, Ji R, Givens R, Jorde U, Takayama H, Naka Y, George I, Mancini D, Schulze PC.  Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantation.  BMC Cardiovasc Disord 2016;16:138-145.
Guerrero M, Dvir D, Himbert D, Urena M, Eleid M, Wang DD, Greenbaum A, Mahadevan VS, Holzhey D, O’Hair D, Dumonteil N, Rodes-Cabau J, Piazza N, Palma JH, DeLago A, Ferrari E, Witkowski A, Wendler O, Kornowski R, Martinez-Clark P, Ciaburri D, Shemin R, Alnasser S, McAllister D, Bena M, Kerendi F, Pavlides G, Sobrinhio JJ, Attizzani GF, George I, Nickenig G, Fass AA, Cribier A, Bapat V, Feldman T, Rihal C, Vahanian A, Webb J, O’Neill W.  Transcatheter Mitral Valve Replacement in Native Mitral Valve Calcific Stenosis with Severe Mitral Annular Calcification.  JACC Cardiovasc Intervent 2016;9(13):1361-71.
Khalique OK, Hamid N, Kodali SK, Nazif TM, Vahl TP, Paradis JM, George I, Leon MB, Hahn RT.  Differences in 3-Dimensional Echocardiographic Measurements of the Aortic Annulus Prior to Transcatheter Aortic Valve Replacement and Impact on Optimal % Oversizing Cutoffs.  (submitted)
Guglielmetti L, Nazif T, Sorabella R, Akkoc D, Kantor A, Gomez A, Wang C, Takayama H, Dizon J, Borger M, George I.  Bicuspid Aortic Valve Increases Risk of Permanent Pacemaker Following Aortic Root Replacement.  Eur J Cardiothorac Surg 2016;50(3):497-503.
Dadson K, Kovacevic V, Rengasamy P, Kim GH, Boo S, Li RK, George I, Schulze PC, Hinz B, Sweeney G.  Cellular, structural, and functional cardiac remodeling following pressure overload and unloading.  Int J Cardiol  2016;216:32-42.
Ota T, Yerebakan H, Neely RC, Mongero L, George I, Takayama H, Williams MR, Naka Y, Argenziano M, Bacha E, Smith CR, Stewart AS.  Short-term Outcomes in Adult Cardiac Surgery in Use of Del Nido Cardioplegia Solution.  Perfusion 2015;31(1):27-33.
Pulerwitz TC, Khalique OK, Nazif TN, Rozenshtein A, Pearson GDN, Vahl T, Kodali SK, George I, Leon MB, Hahn RT, D’Souza B, Po MJ, Einstein AJ.  Very Low Intravenous Contrast Volume Protocol for Computed Tomography Angiography Providing Comprehensive Cardiac and Vascular Assessment for Transcatheter Aortic Valve Replacement in Patients with Chronic Kidney Disease.  J Cardiovasc Comput Tomogr  2016;10(4):316-21.
Sorabella R, Yerebakan H, Najjar M, Bader A, Gomez A, Schulze PC, Mancini D, Takayama H, Naka Y, George I.  The Use of Circulatory Arrest During Heart Transplantation Doe Not Worsen Post-Transplant Survival.  Ann Thorac Surg  2016;102:1260-5.
Lee M, Akashi H, Kato TS, Takayama H, Wu C, Xu K, Collado E, Weber MP, Kennel PJ, Brunhes DL, Ji R, Naka Y, George I, Mancini D, Farr M, Schulze PC.  Vascular Inflammation and abnormal aortic histomorphometry in patients following pulsatile and continuous flow left ventricular assist device placement.  J Heart Lung Transplant 2016;35(9):1085-91.
Guglielmetti L, Sorabella R, Najjar M, Lambert D, Kim E, Kurlansky P, Borger M, Argenziano M, Smith CR, George I.  Bridging Anticoagulation after Aortic Mechanical Heart Valve Replacement-A Questionable Routine?  Ann Thorac Surg  2016;102(1):48-54)
Khalique OK, Pulerwitz TC, Halliburton SS, Kodali SK, Hahn T, Nazif TM, Vahl TP, George I, Leon MB, D’Souza D, Einstein AJ. Practical Considerations for optimizing cardiac computed tomography protocols for comprehensive acquisition prior to transcatheter aortic valve replacement.   J Cardiovasc Comput Tomogr  2016;10(5):364-74.
Sorabella R, Wu YS, Bader A, Smith CR, Takayama H,  Borger MA, George I.  Aortic Root Replacement in Octogenarians Offers Acceptable Perioperative and Late Outcomes.  Ann Thorac Surg 2015;101(3):967-72.
Sorabella RA, Guglielmetti L, Kantor A, Takayama H, Schulze PC, Mancini D, Naka Y, George I.  Cardiac Donor Risk Factors Predictive of Short-Term Heart Transplant Recipient Mortality: An Analysis of the United Network of Organ Sharing Database.  Transplant Proc  2016;47(10):2944-2951.
Tang GH, George I, Hahn RT, Bapat V, Szeto WY, Kodali S.  Transcatheter Mitral Valve Replacement (TMVR): Design Implications, Potential Pitfalls, and Outcome Assessment.  Cardiol Rev  2015;23(6):290-6.
Hahn RT, Fox B, Williams M, Khalique O, George I, Nazif T, Vahl T, Gada H, Hamid N, White J, Parikh P, Leon MB, Kodali SK.  Implantation Characteristics of the Edwards Sapien 3 Transcatheter Heart Valve: An Echocardiographic Study.  (submitted-JASE)
Zizola C, Kennel P, Akashi H, Ji R, Castillero E, George I, Homma S, Schulze PC.  Activation of PPAR delta signaling corrects impaired skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic cardiomyopathy.  Am J Heart Circ Physiol  2015.  doi: 10.1152/ajpheart.00679.2014.
Sorabella RA, Han SM, Grbic M, Wu YS, Takayama H, Kurlansky P, Borger M, Argenziano M, Gordon R, George I.  Early Operation for Endocarditis Complicated by Preoperative Cerebral Emboli is Not Associated with Worsened Outcomes.  Ann Thorac Surg  2015;100(2):501-8.
Hamid N, Khalique O, Kodali SK, Monaghan MJ, Dvir D, Bapat V, Nazif T, Vahl T, George I, Leon MB, Hahn RT.  Transcatheter Valve Implantation in Failed Surgically Inserted Bioprosthesis.  JACC Cardiovasc Imag  2015;8:960-979.
Chai P, George I, Nazif T, Kalfa D, Kodali SK, Torres A, Vincent JA, Leon MB, Bacha EA.  Use of stented bovine pericardial valve for surgical mitral valve replacement in infants.  J Thorac Vasc Surg  2015.  doi: http://dx.doi.org/10.1016/j/jtcvs.2015.09.050.
Castillero E, Akashi H, Najjar M, Kennel P, Wang C, Sweeney HL, Schulze PC, George I.  Cardiac Myostatin Upregulation Occurs Immediately After Myocardial Ischemia and is Involved in Skeletal Muscle Activation of Atrophy.  Biochem Biophys Res Comm 2015;457(1):106-111.
George I, Najjar M, Akashi H, Nishimura T, Yerebakan H, Mongero L, Beck J, Vanderberg J, Takayama H, Williams M.  Continuous Retrograde Administration of Del Nido Cardioplegia: Feasibility and Safety in a Small Series.  J Cardiothorac Surg  2015;10:176-180.
Najjar M, Yerebakan H, Sorabella R, Guglielmetti L, Vandenberge J, Kurlansky P, Williams MR, Argenziano M, Smith CR, George I.  Reversibility of Chronic Kidney Disease and Outcomes Following Aortic Valve Replacement.  Interact Cardiovasc Thorac Surg 2015;21(4):499-505.
Marcoff L, Sun YP, Vahl, T, Bustami R, Kodali S, Williams M, Khalique O, Nazif T, Paradis JM, George I, Leon MB, Hahn RT.  Quantitative Assessment of the Sapien Transcatheter Valve Position, Operator-Independent Motion, and Coaxility by Transesophageal Echocardiography.   (submitted)
Sklepkiewicz P, Takayuki S, Rajbr K, Jie S, Kwon S, Mercer B, Bodine P, Schermuly RT, George I, Schulze PC, D’Armiento JM.  Loss of SFRP-1 Leads to Deterioriation of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy. Circ Heart Fail  2015;8(2):362-72.
Sorabella R, Mamuyac E, Yerebakan H, Najjar M, Choi V, Takayama H, Naka Y, Argenziano M, Smith CR, George I.  Residual Tricuspid Regurgitation Following Tricuspid Valve Repair During Concomitant Valve Surgery Worsens Late Survival.  Heart Surg Forum  2015.  doi: dx.doi.org/10.1532/hsf.1469.
Khalique O, Hahn RT, Gada H, Nazif T, Vahl T, George I, Kalesan B, Williams MR, Leon MB, Kodali SK.  Quantity and Location of Aortic Valve Complex Calcification Predicts Severity and Location of Paravalvular Regurgitation and Frequency of Post-Dilatation After Balloon-Expandable Transcatheter Aortic Valve Replacement.  JACC Cardiovasc Interv  2014; 7(8):885-94.
Proschinske KB, Qiu S, Wu C, Kato TS, Khawaja T, Takayama H, Naka Y, Templeton D, George I, Farr MA, Mancini DM, Schulze PC.  Neutrophil gelatinase-associated lipocalin and cystatin C for the prediction of clinical events in pateints with advanced heart failure, after ventricular assist device placement, and following heart transplantation.  J Heart Lung Transplant 2014;33(12):1215-22.
Forster M, Khalique O, Williams MR, Kodali S, Nazif T, George I, Paradis JM, Grubb K, Marcoff L, Gada H, Vahl T, Leon MB, Hahn RT.  Use of Three Dimensional Transesophageal Echocardiograophic Measurements of the Aortic Annulus and Procedural Outcomes.  (submitted)
Sorabella R, Akashi H, Yerebakan H, Najjar M, Mannan A, Williams MR, Smith CR, George I.  Myocardial Protection Using del Nido Cardioplegia Solution in Adult Reoperative Aortic Valve Surgery.  J Cardiac Surgery 2014;29(4): 445-9.
Yerebakan H, Sorabella R, Najjar M, Castillero E, Mongero L, Beck J, Hossain M, Takayama H, Williams MR, Naka Y, Argenziano M, Bacha E, Smith CR, George I.  Del Nido Cardioplegia Can be Safely Administered in High-Risk Coronary Artery Bypass Grafting Surgery After Acute Myocardial Infarction:  A Propensity Matched Comparison.  J Cardiothoracic Surg 2014;14:1746-9.
Ali ZA, Poludasu S, Qureshi YH, Krishnan P, Ali AA, Tatonetti N, Downey P, Zalewski A, Nazif T, George I, Mandava A, Baber U, Dangas G, Mehran R, Kini A, Sharma SK.  Impact of Major Bleeding on Long Term Mortality in Anemic versus Nonanemic Patients Undergoing Percutaneous Coronary Intervention using Bivalirudin.  Am J Cardiol 2014;113(9):1481-6.
Khawaja T, Chokshi A, Ji R, Kato T, Xu K, Zizola C, Wu C, Forman DE, Ota T, Takayama H, Naka Y, George I, Mancini D, Schulze PC.  Ventricular Assist Device Implantation Improves Skeletal Muscle Function, Oxidative Capacity and Growth Hormone/Insulin-like Growth Factor-1 Axis Signaling in Patients with Advanced Heart Failure.  Cachexia, Sarcopenia, and Muscle 2014;5(4):297-305.
George I, Nazif T, Kalesan B, Kriegel J, Yerebakan H, Kirtane A, Kodali S, Williams M.  Feasibility and Safety of Single-Stage Hybrid Coronary Intervention and Valvular Cardiac Surgery.  Ann Thorac Surg 2015;99(6):2032-7.
Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D’Armiento JM, Ali Z, Schulze PC, George I.  Attenuation of the Unfolded Protein Response and Endoplasmic Reticulum Stress after Mechanical Unloading in Dilated Cardiomyopathy.  AJP Heart, Circ Phys 2015;309(3):H459-70.
George I, Yerebakan H, Kalesan B, Nazif T, Kodali S, Smith CR, Williams MR.  Age Alone Should Not Preclude Surgery: Contemporary Outcomes after Aortic Valve Replacement in Nonagenarians.  J Thorac Cardiovasc Surg 2014;148(4):1360-1369.
Ali A, Downey P, Singh G, Qi W, George I, Takayama H, Kirtane A, Krishnan P, Zalewski A, Freed D, Large SR, Ashley EA, Leon MB, Bacchetta M, Ali ZA.  Rat Model of Veno-Arterial Extracorporeal Membrane Oxygenation.  J Translat Med 2014;12:37.
Yang KC, Yamada KA, Patel AY, Topkara V, George I, Cheema FH, Ewald GA, Mann DL, Nerbonne JM.  Deep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNA in Failing Human and Remodeling with Mechanical Circulatory Support.   Circulation  2014;129(9):1009-21.
Dewey T, Bowers B, Thourani VH, Babaliaros V, Smith CR, Leon MB, Svensson LG, Tuczu M, Miller C, Teirstein P, Tyner J, Brown D, Fontana G, Makkar RR, Williams MR, George I, Kirtane AJ, Bavaria JE, Mack MJ.  Transapical Aortic Valve Replacement for Critical Aortic Stenosis – Results From the Non-Randomized Continued Access Cohort of the Partner Trial.  Annals of Thoracic Surgery 2013;96:2083-9.
Khalique O, Kodali S, Paradis JM, Nazif T, Williams MR, Einstein AJ, Pearson GD, Harjai K, Grubb K, George I, Leon MB, Hahn RT.  Annular Sizing Using a Novel 3-Dimensional Echocardiography Method:  Utility and Comparison to Cardiac Computer Tomography.  Circulation: Cardiovasc Imag 2014;7(1):155-63.
Khalique O, Hamid NB, Kodali SK, Nazif T, Marcoff L, Paradis JM, Williams MR, Vahl TP, George I, Leon MB, Hahn RT.  Improving the Accuracy of Effective Orifice Area Assessment After Transcatheter Aortic Valve Replacement: Validation of Left Ventricular Outflow Tract Diameter and Pulsed-wave Doppler Location and Impact of Three-Dimensional Measurements.  Am Soc Echocardiography 2015;S0894-7317.
George I, Kriegel J, Kalesan B, Paradis JM, Khalique O, Hahn RT, Leon MB, Kodali S, Williams MR.  Transthoracic Access for Transcatheter Aortic Valve Replacement: Technique and Experience using the Edwards Sapien Retroflex Delivery System.  Annals Thorac Surg 2014;98(1):347-9.
Ali ZA, Rinze R, Douglas G, Hu Y, Xiao Q, Qi W, McNeill E, Bursill C, George I, Greaves DR, Xu Q, Channon KM.  Endothelial GTP Cyclohydrolase I and Tetrahydrobiopterin  (BH4) Determine Vascular Remodeling through Enhanced Endothelial Cell Survival and Regeneration.  Circulation 2013;128:S50-8.
George I, Shrikhande G, Williams MR. Stent Exteriorization Facilitates Use as an Alternative Arterial Bypass Conduit.  Catheter Cardiovasc Interv 2013; 82(3):E257-61.
Hahn R, Koss E, Khalique O, Williams MR, Paradis JM, Denault B, Kirtane AJ, George I, Leon MB, Kodali S.  Predicting Paravalvular Regurgitation Following Transcatheter Valve Replacement: Utility of Three-Dimensional Echocardiography Measurements of the Aortic Annulus.  J Am Soc Echocard  2013;26:1043-52.
Denault B, Koss E, Hahn R, Kodali S, Williams MR, Genereux P, Paradis JM, George I, Reiss GR, Moses JW, Smith CR, Leon MB.  Efficacy and Safety of Post-Dilatation to Reduce Para-Valvular Regurgitation During Balloon-Expandable Transcatheter Aortic Valve Replacement.  Circ Cardiovasc Interv  2013;6:85-91.
Zhang X, Ding N, Wang H, Augostini R, Yang B, Xu D, Ju W, Hou X, Li X, Ni B, Cao K, George I, Wang J, Zhang S.  Transvenous Phrenic Nerve Stimulation in Patients with Cheyne-Stokes Respiration and Congestive Heart Failure: A Safety and Proof-of-Concept Study.  Chest  2012;142:927-34.
George I, Bish LT, Maybaum S, Naka Y, Chen J, Sweeney HL.  Myostatin Regulation in Pediatric Cardiomyopathy.  PLoS One  2011;10.1371/journal.pone.0023818.
George I, Xu K, Wang N, Wang J.  β-Adrenergic Receptor Blockade Reduces Endoplasmic Reticulum Stress and Normalizes Calcium Handling in Chronic Heart Failure.  Cardiovascular Research  2011;91(3):447-455.
George I, Xu K, Klotz S, Xydas S, Zhang G, Cerami A, Wang J.  Erythropoeitin Derivate Improves Left Ventricular Systolic Performance and Attenuates Left Ventricular Remodeling in Rats with Myocardial Infarct-Induced Heart Failure.  J Cardiovasc Pharm  2010;56(5):506-512.
George I, Xydas S, Klotz SA, Hay I, Chang J, Li Z, Protter AA, Oz MC, Wang J.  Long-term Effects of B-Type Natriuretic Peptide Infusion After Acute Myocardial Infarction.  J Cardiovasc Pharm  2010;55:14-20.
George I, Bish L, Kamakakkannan G, Oz MC, Naka Y, Sweeney L, Maybaum S.  Myostatin Activation in Patients with Advanced Heart Failure and After Mechanical Unloading.  Eur J Heart Failure  2010;12:444-453.
George I, Yi GH, Morrow B, Holmes J, Xu EX, Li Z, Protter AA, Oz MC, Wang J.  Prolonged Effects of B-Type Natriuretic Peptide Infusion on Cardiac Remodeling After Sustained Myocardial Injury.  Am J Phys-Heart Circ Phys 2009;297:H708-H717.
George I, Shah JN, Bacchetta M, Stewart A.  Stentless Bioprosthesis in Valved Conduits:  Implications for Pulmonary Reconstruction.  Ann Thorac Surg  2009;88:2022-2024.
Russo MJ, Davies RR, Hong KN, Chen JM, Argenziano M, Moskowitz A, Ascheim DD, George I, Stewart AS, Williams M, Gelijins A, Naka Y.  Matching High-Risk Recipients with Marginal Donor Organs is a Clinically Effective Strategy.  Ann Thorac Surg 2009;87:1066-71.
George I, Geddis MS, Lill Z, Lin H, Gomez T, Blank M, Oz MC, Goodman R.  Myocardial Function Improved by Electromagnetic Field Induction of Stress Protein hsp70.  J Cellular Physiol 2008:216;816-823.
George I, Colley P, Russo M, Martens T, Burke E, MC, Deng MC, Mancini DM, Naka Y.  Association of device surface and biomaterials with immunologic sensitization after mechanical support.  J Thorac Cardiovasc Surg 2008;135:1372-9.
Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, Mancini DM, Maybaum S.  Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.  J Heart Lung Transplant 2008;27(4):457-61.
George I, Cheng Y, Yi GH, Reiken S, Gu A, Tao YK, Muraskin J, Qin S, He KL, Hay I, Yu K, Oz MC, Holmes J, Burkhoff D, Wang J.  Bradycardic Therapy Improves Left Ventricular Function and Remodeling in Dogs with Coronary Embolization-Induced Chronic Heart Failure. J Pharm Exp Therap 2007;321(2):469-76.
Russo MJ, Chen JM, Sorabella RA, Martens TM, Garrido M, Davies RR, George I, Cheema FH, Mosca RS, Mital S, Ascheim DD, Argenziano M, Stewart AS, Oz MC, Naka Y.  Effect of ischemic time on survival following heart transplantation varies by donor age: an analysis of the United Network of Organ Sharing Database.  J Thorac Cardiovasc Surg 2007;133:554-9.
George I, Xydas S, Mancini DM, Lamanca J, DiTullio M, Marboe CC, Shane E, Schulman AR, Colley PM, Petrilli CM, Naka Y, Oz MC, Maybaum S.  Effect of Clenbuterol on Cardiac and Skeletal Muscle Function with Ventricular Assist Device Support. J Heart Lung Transplant 2006;25:1084-90.
George I, Xydas S, Topkara VK, Ferdinando C, Barnwell EC, Gableman L, Sladen R, Naka Y, Oz MC.  Clinical Indication for Use and Outcomes After Inhaled Nitric Oxide.  Annals of Thoracic Surgery 2006;82:2161-2169.
Russo MJ, Davies RR, Sorabella RA, Martens TM, George I, Cheema FH, Mital S, Mosca RS, Chen JM.  Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network of Organ Sharing Database.  J Thorac Cardiovasc Surg 2006;132(5):1208-12.
Bardakci H, Cheema FH, Topkara VK, Dang NC, Martens TP, Mercando ML, Forster CS, George I, Russo MJ, Oz MC, Esrig BC.  Discharge-to-Home Rates in Octogenarians Are Significantly Lower in Coronary Artery Bypass Grafting Patients.  Ann Thorac Surg 2007;83:483-489.
George I, Yi GH, Schulman AR, Morrow BT, Cheng Y, Gu A, Zhang G, Oz MC, Burkhoff D, Wang J.  A Polymerized Bovine Hemoglobin Oxygen Carrier Preserves Regional Myocardial Function and Reduces Infarct Size after Acute Myocardial Ischemia.  Am J Physiol – Heart Circ Phys 2006;291:H1126-H1137.
George I, Cheng Y, Yi GH, He KL, Li X, Oz MC, Holmes J, Wang J.  Effect of Passive Cardiac Containment on Ventricular Synchrony and Cardiac Function in Awake Dogs. Euro J Cardiothorac Surg 2007;31:55-64.
George I, Yi GH, He KL, Lee MJ, Calahan P, Zhang G, Gu A, Klotz S, Burkhoff DB, Wang J.  Direct Left Ventricle to Coronary Artery Stent Restores Perfusion to Ischemic Swine Myocardium.  Heart Surgery Forum 2006;9(5):E744-9.
Topkara VK, Dang NC, Barili F, Martens TP, George I, Cheema FH, Bardacki H, Ozcan AV, Naka Y.  Ventricular Assist Device use for the treatment of acute viral myocarditis.  J Thorac Cardiovasc Surg 2006;131(5):1190-1.
Topkara VK, Dang NC, Barili F, Cheema FH, Martens TP, George I, Bardakci H, Oz MC, Naka Y. Predictors and outcomes of continuous venovenous hemodialysis use after left ventricular assist device implantation.  J Heart Lung Transplant 2006;25(4):404-8.
Spina R, Olds A, George I.  Interventions for Structural Heart Disease.  The Johns Hopkins Textbook of Cardiothoracic Surgery (3rd Edition).  Yu D. The McGraw-Hill Companies, Inc, 2018.
Praz F, George I.  Direct transatrial approach with resection of the anterior mitral leaflet to prevent outflow tract obstruction.  Transcatheter Mitral Valve Therapies (1st Edition).  Waksman R, Feldman T, Rogers T, 2018.
George I, Smith CR.  The Future of TAVR.  Heart Disease (9th Edition).  Braunwald E.  Saunders, Elsevier Science, 2013. 
Grubbs, K, George I, Williams MR.  Transcatheter Valve-in-Valve Replacement as a Treatment for Failed Bioprosthetic Valves.  Cardiac Surgical Techniques (1st Edition).  Franco K, Roselli E, Slaughter M, Thourani V, 2013.
George I, Reiss GR, Williams MR.  Transcatheter Aortic Valve Replacement.  Mastery of Cardiothoracic Surgery, 3rd Edition.  Kaiser L, Kron I, Spray T.  Wolters Kluwer Health Inc, 2013.
George I, Williams MR.  Myocardial Revascularization after Acute Myocardial Infarction.  Cardiac Surgery in the Adult (4th Edition).  Cohn LH, Edmunds LH Jr.  The McGraw-Hill Companies, Inc., 2011.
George I, Oz MC.  Myocardial Revascularization after Acute Myocardial Infarction.  Cardiac Surgery in the Adult (3rd Edition).  Cohn LH, Edmunds LH Jr.  The McGraw-Hill Companies, Inc., 2007.