Profile image of Jennifer R. DeFazio, MD

Jennifer R. DeFazio, MD

Director, Bowel Management Program


Pediatric Surgery


Jennifer DeFazio, MD, is a board-certified pediatric surgeon. She treats a broad range of pediatric conditions and is especially interested in the surgical management of neonatal and congenital diseases, complex anorectal disorders, metabolic disease and Median Arcuate Ligament Syndrome (MALS). She is also part of the Bowel Management Program.


**Surgical Infection Society 1st place oral presentation, 2014

American College of Surgeons Scholarship to attend Leadership conference, 2014

Academic Award for Surgery, 2013, 2016

*Surgical Infection Society 3rd place poster, Las Vegas, NV 2013

Four Varsity Letters in Women’s Gymnastics, 2001-2005

Academic All-American, 2002-2005

President’s Award for Gymnastics, 2001-2005

Tau Beta Pi, engineering honor society, 2005

Chi Alpha Sigma, National College Athlete Honor Society, 2005

Illinois Lieutenant Governor’s Award for Service and Leadership, 2005


Lax S, Sangwan N, Smith D, Larsen P, Handley KM, Richardson M, Guyton K, Krezalek M, Shogan BD, DeFazio J, Flemming I, Shakhsheer B, Weber S, Landon E, Garcia-Houchins S, Siegel J, Alverdy J, Knight R, Stephens B, Gilbert JA. Bacterial colonization and succession in a newly opened hospital. Sci Transl Med. 2017 May 24;9(391).

Fleming ID, Krezalek MA, Belogortseva N, Zaborin A, DeFazio J, Chandrasekar L, Actis LA, Zaborina O, Alverdy JC. Modeling Acinetobacter baumannii wound infections: The critical role of iron. J Trauma Acute Care Surg. 2017 Mar, 82(3): 557-65.

Zaborin A, Krezalek M, Hyoju S, DeFazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC. Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress. Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G112-122.

Shaksheer BA, Versten LA, Luo JN, DeFazio JR, Klabbers R, Christley S, Zaborin A, Guyton KL, Krezalek M, Smith DP, Ajami J+NJ, Petrosino JR, Fleming ID, Belogortseva N, Zaborina O, Alverdy JC. Morphine promotes colonization of anastomotic tissues with collagenase - producing enterococcus faecalis and cases leak. J Gastrointest Surg. 2016 Oct; 20 (10):1744-51.

Brown CS, DeFazio JR, An G, O'Connor A, Whitcomb E, Hart J, Gottlieb, LJ. Toxic Epidermal Necrolysis with Gastrointestinal Involvement - A Case Report and Review of the Literature. J Burn Care Res. 2016 Mar 30.

Krezalek M, DeFazio JR, Zaborina O, Zaborin A, Alverdy JC. The shift of an intestinal "microbiome" to a "pathobiome" governs the course and outcome of sepsis following surgical injury. Shock. 2016 May; 45(5):475-82.

DeFazio JR, Fleming ID, Shakhsheer B, Zaborina O, Alverdy JC. The opposing forces of the intestinal Microbiome and the emerging pathobiome. Surg Clinics North Am. 2014 Dec; 94(6):1151-61.

Alverdy JC, Gilbert J, DeFazio, JR, Sadowsky M, Chang E, Morowitz M, Teitelbaum D. Proceedings the ASPENsponsored workshop: "The Interface between Nutrition and the Gut Microbiome: Implications and Applications for Human Health." J Parenter Enteral Nutr. 2014 Feb; 28(2):167-78.

Zaborin A, Defazio JR, Kade M, Kaiser BL, Belogortseva N, Camp D, Smith RD, Adkins JN, Kim S, Alverdy A, Goldfield D, Firestone MA, Collier J, Jabri B, Tirrell M, Zaborina O, Alverdy JC. Phosphate- containing PEG polymers prevent lethal sepsis from multi-drug resistant pathogens. Antimicrob Agents Chemother. 2014 Feb; 58(2):966-77.

Sundararaghavan HG, Monteiro GA, Lapin NA, Chabal YJ, Miksan JR, Shreiber DI. "Genipin-induced changes in collagen gels: correlation of mechanical properties to fluorescence." J Biomed Mater Res A. 2008 Nov; 87(2):308-20.