Research at Takayama Lab

Hiroo Takayama MD

Current Research Focus

Dr. Takayama's research focuses on advancing the understanding and surgical treatment of aortic valve and aortic disease through translational research, advanced imaging, and clinical outcomes studies. His laboratory investigates how altered fluid dynamics contribute to aortic valve degeneration and aortic insufficiency, while leveraging imaging technologies to improve surgical planning and patient outcomes. As Co-Director of a major Aortic Center, Dr. Takayama also leads research on bicuspid aortic valve (BAV) disease, utilizing one of the nation's largest BAV databases to optimize surgical management and refine treatment strategies. His work integrates innovative imaging modalities, tissue analysis, and computational flow assessment to enhance both open and transcatheter cardiovascular procedures.

Selected Recent Publications (2024–Present)

  • Blood Flow Assessment Technology in Aortic Surgery: A Narrative Review. Journal of Thoracic Disease (2024).
  • Long-term Outcomes After Aortic Root Replacement for Bicuspid Aortic Valve-Associated Aneurysm. Journal of Thoracic and Cardiovascular Surgery (2025).
  • Left Ventricular Reverse Remodeling After Aortic Valve Replacement or Repair in Bicuspid Aortic Valve With Moderate or Greater Aortic Regurgitation. JTCVS Open (2024).
  • Incidence, Risk Factors, and Long-term Outcomes Associated With Permanent Pacemaker Implantation After Aortic Root Replacement. Journal of Thoracic and Cardiovascular Surgery (2025).
  • Safety of Concomitant Ascending Aortic Aneurysm Repair During Coronary Artery Bypass Grafting. Annals of Thoracic Surgery (2025).
  • Seven-Year Results for RESILIA Tissue in Bicuspid Aortic Valve Replacement Patients. Interdisciplinary Cardiovascular and Thoracic Surgery (2025).
  • Valve-Sparing Aortic Root Replacement in Resternotomy Settings. Journal of Thoracic and Cardiovascular Surgery (2025).

Grants & Funding (2024–Present)

  • Research support from The Rudin Foundation.Awards & Honors (2024–Present)
  • No new awards or honors reported for this period.

Leadership & Other Important Contributions

  • Co-Director of a major Aortic Center.
  • Leads research on bicuspid aortic valve disease using one of the nation's largest clinical databases.
  • Advances the use of high-resolution imaging and flow dynamics for cardiac and aortic surgery.
  • Develops innovative surgical approaches through multidisciplinary collaboration and translational research.