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Prospective Randomized Double Blind Placebo Controlled Trial of Rifaximin 550mg PO Twice Daily for Three Months to Prevent Recurrent Fibrosis in Liver Transplant Recipients with Chronic Hepatitis C Virus Infection
… reduce the amount of fibrosis (or scarring of the liver) in liver transplant patients with recurrent hepatitis C virus … by lowering serum lipopolysaccharide (LPS), a protein in blood that comes from the bacteria in intestines and may cause scarring in the liver. …
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A Phase 3, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Sofosbuvir/GS-5816 Fixed-Dose Combination in Subjects with Chronic HCV Infection and Child-Pugh Class B Cirrhosis
… (RBV) for 12 weeks and SOF/GS-5816 FDC for 24 weeks in adults with hepatitis C virus (HCV) infection and … and Safety of Sofosbuvir/GS-5816 Fixed-Dose Combination in Subjects with Chronic HCV Infection and Child-Pugh Class B …
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A Phase Ib/2, Multicenter, Open-label Trial to Evaluate the Safety and Efficacy of Talimogene Laherparepvec and Ipilimumab Compared to Ipilimumab Alone in Subjects with Previously Untreated, Unresected, Stage IIIB-IV Melanoma
… laherparepvec (formerly known as OncoVEXGM-CSF), in people with advanced melanoma when given in combination with another drug called ipilimumab. Melanoma … to other parts of the body. The study will be conducted in two parts. Phase 1 of the study will see if talimogene …
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A randomized, parallel-group, double-blind, placebo-controlled, multi-center study of eculizumab for the prevention of delayed graft function after kidney transplantation in adult subjects at increased risk of delayed graft function.
… safety of a two dose regimen of eculizumab to prevent DGF in adult patients undergoing deceased-donor kidney … of delayed graft function after kidney transplantation in adult subjects at increased risk of delayed graft function. …
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An Expanded Access Phase 2 Study of Sofosbuvir with Ribavirin and with or without Pegylated Interferon for 24 weeks in Subjects who have undergone Liver Transplantation and Who Have Aggressive, Recurrent Hepatitis C infection
… and with or without Pegylated Interferon for 24 weeks in Subjects who have undergone Liver Transplantation and Who …
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Phase II Open-Label, Single-Center Study Evaluating Safety and Efficacy of Pembrolizumab Following Induction with the Hypomethylating Agent Azacitidine in Patients with Advanced Pancreatic Cancer After Failure of First-Line Therapy
… Induction with the Hypomethylating Agent Azacitidine in Patients with Advanced Pancreatic Cancer After Failure of …
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Multicenter, Randomized Phase 2B Study to Evaluate the Efficacy, Safety, and Tolerability of OCR-002 (Ornithine Phenylacetate) in Hospitalized Patients with Cirrhosis and Associated Hyperammonemia with an Episode of Hepatic Encephalopathy (STOP-HE)
… hepatic encephalopathy episode requiring hospitalization in cirrhotic patients. Trial Website: … and Tolerability of OCR-002 (Ornithine Phenylacetate) in Hospitalized Patients with Cirrhosis and Associated …
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Prospective, Multi-Center, Open Label, Pilot Study of Safety and Efficacy of Triple Anti-Viral Therapy with Pegylated Interferon, Ribavirin, and Boceprevir in Patients with Genotype 1 Chronic HCV with End Stage Renal Disease
… pegylated interferon (P-IFN), ribavirin and boceprevir in patients with genotype 1 chronic Hepatitis C Virus (HCV) … with Pegylated Interferon, Ribavirin, and Boceprevir in Patients with Genotype 1 Chronic HCV with End Stage Renal …
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A Randomized, Double-blind, Placebo-controlled, Dose-ranging, Multicenter Study to Assess the Efficacy and Safety of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Prevention of Complications in Subjects With Early Decompensated Liver Cirrhosis
… is to assess the efficacy of rifaximin SSD versus placebo in preventing complications of liver cirrhosis, such as … mortality (death due to all causes) or hospitalization, in subjects with early decompensated liver cirrhosis. … is currently marketed as a 550 mg tablet for the reduction in risk of recurrent overt hepatic encephalopathy, a …
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A Phase 2, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose Combination + Ribavirin Administered in Subjects Infected with Chronic HCV who have Advanced Liver Disease or are Post-Transplant
… (LDV/SOF) fixed-dose combination (FDC) in participants with chronic genotype 1 or 4 hepatitis C … Fixed-Dose Combination + Ribavirin Administered in Subjects Infected with Chronic HCV who have Advanced Liver …
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Obesity and the Flu: Five Questions with Bariatric Surgeon Dr. Francisco Guzman
… weather can’t seem to make up its wintery mind, and we’re in the throes of flu season. In recent years, we’ve seen several studies digging deeper … of other illnesses. Meaning that because obesity is a pro-inflammatory state it plays a negative role in how our …
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New Cocktail Boosts Recovery from Hepatitis C
… disease, a cocktail is normally a forbidden luxury. But in some cases, it may be just what the doctor ordered. Two … drugs (telaprevir and boceprevir) to antivirals already in use for Hepatitis C (pegylated interferon and ribavirin). … The addition of telaprevir or boceprevir can result in more substantial anemia, sometimes requiring a …
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An Interview with Dr. Craig Smith, Heart Surgeon, Chair of Surgery, and Author of Nobility in Small Things
… professional contributions. What we come to learn in Dr. Smith’s new memoir, Nobility in Small Things: A Surgeon’s Path , is what lies beneath the … say those words. You said two things at very different points of reflection on your life that come to mind. The …
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Your Dietitian’s Dish
… Pancreas Center I am always asking my patients to tell me, in great detail, exactly what they eat on a typical day. … once, I would turn the tables around and share with you, in great detail, exactly what I eat on a typical day. If you … Nutrition breakdown: 277 calories, 50 g carbohydrate, 8 g pro, 5 g fat, 12 g fiber If I am home, I will also sometimes …
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The Heart: A Love Story
… of love and affection. We see its iconography everywhere: in artwork, fashion, advertising--and all over our phone … connection between the human heart and love was cemented in the Medieval era, but the scalloped heart shape had use of … grew so obsessed with silphium that they stamped silver coins with the plant’s heart-shaped seedpod on one side and …
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