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The Study of Molecular Risk Panels in Chinese Breast Cancer Patient using Mammaprint, TargetPrint, BluePrint and Research Gene Panel assays.
… of their tissue are then sent for genetic analysis, and DNA testing is performed on blood samples. Results will be used to identify molecular characteristics and biomarkers in premenopausal Chinese women with breast … determined by clinical parameters, standard staging and IHC analysis; to identify correlations between molecular …
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A Phase 1/2 Study Of The Safety, Tolerability And Efficacy Of INCB24360 Administered In Combination With Nivolumab In Select Advanced Cancers
… purpose of this research study is to assess how safe and well tolerated the study drugs, INCB024360 and nivolumab, are when given in combination in patients who … cell lung cancer (NSCLC), colorectal cancer, head and neck squamous cell carcinoma, ovarian cancer and diffuse …
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ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Mitral Bioprostheses (Models 11000A and 11000M) With a New Tissue Treatment Platform (COMMENCE)
… modifications to tissue processing, valve sterilization and packaging do not raise any new questions of safety and effectiveness in subjects who require replacement of … of Edwards Pericardial Mitral Bioprostheses (Models 11000A and 11000M) With a New Tissue Treatment Platform (COMMENCE) …
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Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Chronic Hepatitis C Participants With Child-Pugh (CP)-B Hepatic Insufficiency
… A Phase II/III Clinical Trial to Study the Efficacy and Safety of the Combination Regimen of MK-5172 and MK-8742 ± Ribavirin (RBV) in Subjects with Chronic … Hepatitis C Virus Infection with Advanced Cirrhosis and Child-Pugh (CP)-B Hepatic Insufficiency This study is …
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Intranasal Oxytocin Use in Identifying the Micro-RNA Fingerprint in NAF, Serum, and Tissue in Patients with DCIS or Invasive Breast Cancer
… microRNA profiles in nipple aspirate fluid (NAF), serum, and tissue of women diagnosed with DCIS or invasive breast … from ductal epithelium, it is possible that cells and secretions collected from such ducts would allow for … identify biomarkers that predict the risk of breast cancer and/or detect breast cancer in its early stages. …
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A Phase 1 First-in-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 228 in Subjects with Selected Advanced Solid Tumors
… people that have advanced non-small cell lung cancer, head and neck cancer, melanoma, colon cancer, or bladder cancer. … look at what doses of AMG 228 are safe for people to take and whether it causes any side effects. … Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 228 in Subjects with Selected …
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A Randomized Trial Comparing the ELUVIA™ Drug-eluting Stent Versus Zilver® PTX® Stent for Treatment of Superficial Femoral and/or Proximal Popliteal Arteries
… primary objective of this trial is to evaluate the safety and effectiveness of the ELUVIA Drug-Eluting Vascular Stent … Zilver® PTX® Stent for Treatment of Superficial Femoral and/or Proximal Popliteal Arteries …
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Spotlight on the late Frederic Pratt Herter, MD, Auchincloss Professor Emeritus of Surgery and Acting Chairman (1969-1971) of the Department of Surgery
… Dr. Craig R. Smith and the Department of Surgery at Columbia University College of Physicians and Surgeons mourn the passing of Dr. Frederic P. Herter, our esteemed colleague and mentor. Auchincloss Professor Emeritus of Surgery and … Herter, MD, Auchincloss Professor Emeritus of Surgery and Acting Chairman (1969-1971) of the Department of Surgery …
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A Randomized, Phase II Trial of Intermittent Versus Continuous Dosing of Dabrafenib NSC-763760) and Trametinib (NSC-763093) in BRAFV600E/K Mutant Melanoma
… The purpose of this study is to compare any good and bad effects of receiving the drugs dabrafenib and trametinib continuously to receiving dabrafenib and trametinib with a break in treatment. Dabrafenib and … Versus Continuous Dosing of Dabrafenib NSC-763760) and Trametinib (NSC-763093) in BRAFV600E/K Mutant Melanoma …
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A Prospective, Multicenter, Non-Blinded, Non-Randomized Study of the Relay PRO Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers
… in subjects with Thoracic Aortic Aneurysms (TAAs) and Penetrating Atherosclerotic Ulcers (PAUs) The purpose of this study is to investigate the safety and effectiveness of the Relay PRO Thoracic Stent-Grafts in subjects with aneurysms and PAUs within the descending thoracic aorta . The primary …
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A single center, open-label, randomized, controlled pilot trial to evaluate the efficacy and safety of everolimus conversion versus standard immunosuppression in liver transplant recipients
… as determined by renal function, rejection rates, and progression to fibrosis (in HCV positive subjects). Additionally, safety profile and tolerability of these regimens will be assessed. Trial … controlled pilot trial to evaluate the efficacy and safety of everolimus conversion versus standard …
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Open-Label, Dose-Escalation Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Daily Oral MGCD265 Administered Without Interruption to Patients with Advanced Malignancies
… with advanced cancer. The safety of this drug, and the effect that it has on the participants disease and your body will also be studied. MGCD265 is a drug that … growth of new blood vessels that help cancer tumors grow and spread. MGCD265 an investigational agent. This means that …
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A Study of the Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors
… is a randomized, multicenter, open-label, dose-exploration and dose-expansion study to evaluate the safety, … tolerability, antitumor activity, PK, pharmacodynamics, and immunogenicity of MEDI4736 in combination with … With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive …
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A Phase 1, Open-label Study to Evaluate the Safety and Tolerability of MEDI0680 (AMP-514) in Combination with MEDI4736 in Subjects with Advanced Malignancies
… purpose of this research study is to determine how safe and tolerable MEDI0680 (AMP-514) and MEDI4736 are when given together in subjects with advanced cancers. MEDI0680 (AMP-514) and MEDI4736 are monoclonal antibodies that may prevent … A Phase 1, Open-label Study to Evaluate the Safety and Tolerability of MEDI0680 (AMP-514) in Combination with …
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An Observational Cohort Study to Determine the Impact of Alloantibodies and Antibodies to Self Antigens on Chronic Allograft Function up to 5 years after Pediatric Heart Transplantation.
… Long term follow up for CTOTC-04 patients and 2 year observational study looking at allo-antibodies in newly transplanted patients both sensitized and non sensitized. … Cohort Study to Determine the Impact of Alloantibodies and Antibodies to Self Antigens on Chronic Allograft Function …
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