By studying mastectomy specimens with DCIS, we hope to delineate breast ductal anatomy, gain a better understanding of ductal layout, and fundamentally impact management and treatment of breast disease.
The main purpose of this research is to determine whether injecting mesenchymal precursor cells (MPC) into the heart during surgery to implant a left ventricular assist device (LVAD) is safe. MPCs are normally present in human bone marrow and have been shown to increase the development of blood vessels and new heart muscle cells in the heart. In addition, this research is being done to test whether injecting the MPCs into the heart is effective in improving heart function.
To evaluate the efficacy and safety of embolic protection devices to reduce ischemic brain injury in patients undergoing surgical aortic valve replacement (AVR).
To evaluate levosimendan compared with placebo in reducing the composite event rate of all-cause death, perioperative MI, need for new dialysis, or use of mechanical assist (IABP, LVAD or ECMO) in subjects with reduced ejection fraction undergoing cardiac surgery on cardiopulmonary bypass (CPB).
To assess the impact of the CytoSorb device during cardiopulmonary bypass compared to standard of care without CytoSorb. Measures include change in plasma free hemoglobin; assessment of device-related adverse events; time on ventilator; time in ICU; hospital stay; incidence of acute kidney injury; and others.
The Mammaprint study is a genetic study among Chinese women with breast cancer. The purpose of this study is to identify molecular factors or biomarkers that may be used to assess risk for breast cancer in this population. Identification of such markers could facilitate better risk assessment, detection methods, as well as development of better-targeted therapies.
In this study, patients first undergo surgery to remove their breast cancer. Samples of their tissue are then sent for genetic analysis, and DNA testing is performed on blood samples.
To assess the assess the potential advantages and disadvantages of interstitial laser therapy (ILT) compared to lumpectomy.
To to test whether patients undergoing a breast MRI (magnetic resonance imaging) before breast surgery will have better results after the surgery.
The purpose of the clinical study is to prove that the heart valve device is safe, effective, and performs as intended.
Low cardiac output syndrome (LCOs) is a serious complication in critically ill patients or those undergoing major surgery, resulting in multiple organ damage with significant in-hospital and long-term morbidity and mortality, as well as prolonged hospital stay. In this setting the mortality rate is distressingly high despite improvements in intensive care treatment, but survivors have an acceptable quality of life.