Profile image of William  Middlesworth, MD

William Middlesworth, MD

Director, Pediatric Extracorporeal Membrane Oxygenation Program NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY
Director, Pediatric Surgery Fellowship, Morgan Stanley Children's Hospital/NewYork-Presbyterian Hospital


Cancer Care
Endocrine Tumor
General Surgery
Newborn Surgery
Pancreatobiliary Disease
Pediatric Cancer
Pediatric Minimal Access Surgery
Pediatric Surgery
Pediatric Trauma


Dr. William Middlesworth joined the medical staff of Morgan Stanley Children’s Hospital of NewYork-Presbyterian/Columbia (MSCHONY), Division of Pediatric Surgery in 1997. He currently serves as director of the Pediatric ECMO Program, and Residency Program Director of the Pediatric Surgical Fellowship. Dr. Middlesworth has founded and leads the Pediatric Thyroid Center and the REACH (Researching Esophageal Atresia for Children’s Health) Clinic.

A graduate of Dartmouth College, Dr. Middlesworth spent two years in the Genetics Department at the Boston Children’s Hospital on work leading to the identification and characterization of the dystrophin gene, important in the pathophysiology of muscular dystrophy. He went on to medical school at Rutgers University, and completed his general surgery training at the University of Maryland Medical System. During residency he spent a year as a surgical research fellow at the Royal Children’s Hospital in Melbourne, Australia. His pediatric surgery fellowship was completed at MSCHONY.

In addition to the responsibilities listed above, Dr. Middlesworth serves on numerous hospital and university committees focused on Quality and Patient Safety, and is the Quality Chair for Columbia Department of Surgery. He is the Surgeon Champion at the Columbia campus for the National Surgical Quality Improvement Project (NSQIP) of the American College of Surgeons. He chairs a multi-institution collaborative to reduce harm and enhance safety in the peri-operative setting that is sponsored by MCIC Vermont, the member-owned malpractice insurance carrier for Columbia, Cornell, New York Presbyterian Hospital, Johns Hopkins Medicine, University of Rochester Medicine and Yale.

Dr. Middlesworth is a fellow of the American College of Surgeons, and the American Academy of Pediatrics. He is a member of numerous professional organizations dedicated to advancing the surgical care of infants and children, including the American Pediatric Surgical Association (APSA), the Eastern Association for the Surgery of Trauma(EAST) and the Extra-corporeal Life Support Organization(ELSO), among others.

Dr. Middlesworth has been selected as a Best Doctor in New York Magazine, and a Castle Connolly Top Doctor. He has received recognition for excellence in teaching, and authored numerous papers in important journals including the Journal of Pediatric Surgery, the Journal of Pediatric Hematology and Oncology and Pediatric Critical Care Medicine.


New York Magazine's Top Doctors, 2015-2016


Quality improvement and patient safety
Esophageal Atresia


Wang J, Ahimaz PR, Hashemifar S, Khlevner J, Picoraro JA, Middlesworth W, Elfiky MM, Que J, Shen Y, Chung WK. Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing. Eur J Hum Genet. 2021 Jan;29(1):122-130. doi: 10.1038/s41431-020-0680-2. Epub 2020 Jul 8. PMID: 32641753; PMCID: PMC7852873.

A comparison of bronchoalveolar lavage versus lung biopsy in pediatric recipients after stem cell transplantation. Qualter E, Satwani P, Ricci A, Jin Z, Geyer MB, Alobeid B, Radhakrishnan K, Bye M, Middlesworth W, Della-Letta P, Behr G, Muniz M, van de Ven C, Harrison L, Morris E, Cairo MS. Biol Blood Marrow Transplant. 2014 Aug;20(8):1229-37

Ultrasonography/MRI versus CT for diagnosing appendicitis. Aspelund G, Fingeret A, Gross E, Kessler D, Keung C, Thirumoorthi A, Oh PS, Behr G, Chen S, Lampl B, Middlesworth W, Kandel J, Ruzal-Shapiro C. Pediatrics. 2014 Apr;133(4):586-93. doi: 10.1542/peds.2013-2128. Epub 2014 Mar 3.

Isolated primary testicular B lymphoblastic lymphoma: an unusual presentation. Garcia AV, Alobeid B, Traina JM, Chen SS, Weiner MA, Middlesworth W. J Pediatr Hematol Oncol. 2013 Mar;35(2):

The use of recombinant tissue-type plasminogen activator in a newborn with an intracardiac thrombus developed during extracorporeal membrane oxygenation. Garcia A, Gander JW, Gross ER, Reichstein A, Sheth SS, Stolar CJ, Middlesworth W. J Pediatr Surg. 2011 Oct;46(10):2021-4.

A common symptom of an uncommon disease. Sia VM, Sia DC, Yamashiro DJ, Middlesworth W, Syed M, Paudel G, Kirk R, Kigongo-Mwesezi S, Rivlin K, Leggiadro RJ. J Pediatr Hematol Oncol. 2011 Jul;33(5):390-1.

Outcomes research in pediatric surgery. Part 2: how to structure a research question. Chang DC, Rhee DS, Papandria D, Aspelund G, Cowles RA, Huang EY, Chen C, Middlesworth W, Arca MJ, Abdullah F. J Pediatr Surg. 2011 Jan;46(1):226-31.

Thoracoscopic lobectomy in infants less than 10 kg with prenatally diagnosed cystic lung disease. Rothenberg SS, Kuenzler KA, Middlesworth W, Kay S, Yoder S, Shipman K, Rodriguez R, Stolar CJ. J Laparoendosc Adv Surg Tech A. 2011 Mar;21(2):181-4. Epub 2011 Jan 8.

Limb ischemia after common femoral artery cannulation for venoarterial extracorporeal membrane oxygenation: an unresolved problem. Gander JW, Fisher JC, Reichstein AR, Gross ER, Aspelund G, Middlesworth W, Stolar CJ. J Pediatr Surg. 2010 Nov;45(11):2136-40.

Laparoscopic excision of choledochal cysts with total intracorporeal reconstruction. Gander JW, Cowles RA, Gross ER, Reichstein AR, Chin A, Zitsman JL, Middlesworth W, Rothenberg SS. J Laparoendosc Adv Surg Tech A. 2010 Dec;20(10):877-81. Epub 2010 Sep 29.

Fulminant pH1N1-09 influenza-associated myocarditis in pediatric patients. Gross ER, Gander JW, Reichstein A, Cowles RA, Stolar CJ, Middlesworth W. Pediatr Crit Care Med. 2011 Mar;12(2):e99-e101.

Thoracoscopic lobectomy for severe bronchiectasis in children. Rothenberg SS, Kuenzler KA, Middlesworth W. J Laparoendosc Adv Surg Tech A. 2009 Aug;19(4):555-7.

Percutaneous distal perfusion of the lower extremity after femoral cannulation for venoarterial extracorporeal membrane oxygenation in a small child. Haley MJ, Fisher JC, Ruiz-Elizalde AR, Stolar CJ, Morrissey NJ, Middlesworth W. J Pediatr Surg. 2009 Feb;44(2):437-40.

Therapeutic plasma exchange performed in parallel with extra corporeal membrane oxygenation for antibody mediated rejection after heart transplantation. Jhang J, Middlesworth W, Shaw R, Charette K, Papa J, Jefferson R, Torloni AS, Schwartz J. J Clin Apher. 2007;22(6):333-8.

Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Huang J, Soffer SZ, Kim ES, McCrudden KW, Huang J, New T, Manley CA, Middlesworth W, O'Toole K, Yamashiro DJ, Kandel JJ. Mol Cancer Res. 2004 Jan;2(1):36-42.

Duodenal atresia associated with proximal jejunal perforations: a case report and review of the literature. Sajja SB, Middlesworth W, Niazi M, Schein M, Gerst PH. J Pediatr Surg. 2003 Sep;38(9):1396-8. Review.

Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis. McCrudden KW, Hopkins B, Frischer J, Novikov A, Huang J, Kadenhe A, New T, Yokoi A, Yamashiro DJ, Kandel JJ, Middlesworth W. J Pediatr Surg. 2003 Mar;38(3):308-14; discussion 308-14.

Topotecan is anti-angiogenic in experimental hepatoblastoma. McCrudden KW, Yokoi A, Thosani A, Soffer SZ, Kim ES, Huang J, Manley C, O'toole K, Yamashiro DJ, Kandel JJ, Middlesworth W. J Pediatr Surg. 2002 Jun;37(6):857-61.

Resistance of a VEGF-producing tumor to anti-VEGF antibody: unimpeded growth of human rhabdoid tumor xenografts. Soffer SZ, Kim E, Huang J, McCrudden K, Yokoi A, Moore JT, Manley C, O'Toole K,Middlesworth W, Stolar C, Yamashiro DJ, Kandel JJ. J Pediatr Surg. 2002 Mar;37(3):528-32.

p53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease. Huang J, Soffer SZ, Kim ES, Yokoi A, Moore JT, McCrudden KW, Manley C, Middlesworth W, O'Toole K, Stolar C, Yamashiro DJ, Kandel JJ. J Pediatr Surg. 2002 Mar;37(3):523-7.

Distinct response of experimental neuroblastoma to combination antiangiogenic strategies. Kim ES, Soffer SZ, Huang J, McCrudden KW, Yokoi A, Manley CA, Middlesworth W, Kandel JJ, Yamashiro DJ. J Pediatr Surg. 2002 Mar;37(3):518-22.

Novel use of an established agent: Topotecan is anti-angiogenic in experimental Wilms tumor. Soffer SZ, Kim E, Moore JT, Huang J, Yokoi A, Manley C, O'Toole K, Middlesworth W, Stolar C, Yamashiro D, Kandel J. J Pediatr Surg. 2001 Dec;36(12):1781-4.

Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor. Soffer SZ, Moore JT, Kim E, Huang J, Yokoi A, Manley C, O'Toole K, Stolar C,Middlesworth W, Yamashiro DJ, Kandel JJ. J Pediatr Surg. 2001 Aug;36(8):1177-81.

Highly specific antiangiogenic therapy is effective in suppressing growth of experimental Wilms tumors. Huang J, Moore J, Soffer S, Kim E, Rowe D, Manley CA, O'Toole K, Middlesworth W, Stolar C, Yamashiro D, Kandel J. J Pediatr Surg. 2001 Feb;36(2):357-61.

All angiogenesis is not the same: Distinct patterns of response to antiangiogenic therapy in experimental neuroblastoma and Wilms tumor. Kim E, Moore J, Huang J, Soffer S, Manley CA, O'Toole K, Middlesworth W, Stolar CJ, Kandel JJ, Yamashiro DJ. J Pediatr Surg. 2001 Feb;36(2):287-90.

Trisomy 1q, 2, and 20 in a case of hepatoblastoma: possible significance of 2q35-q37 and 1q12-q21 rearrangements. Yeh YA, Rao PH, Cigna CT, Middlesworth W, Lefkowitch JH, Murty VV. Cancer Genet Cytogenet. 2000 Dec;123(2):140-3. Review.

Biliary atresia. Middlesworth W, Altman RP. Curr Opin Pediatr. 1997 Jun;9(3):265-9. Review.

Prenatal androgen blockade with flutamide inhibits masculinization of the genitofemoral nerve and testicular descent. Goh DW, Middlesworth W, Farmer PJ, Hutson JM. J Pediatr Surg. 1994 Jun;29(6):836-8.

The relationship among calcitonin gene-related peptide, androgens and gubernacular development in 3 animal models of cryptorchidism. Goh DW, Momose Y, Middlesworth W, Hutson JM. J Urol. 1993 Aug;150(2 Pt 2):574-6.

Exogenous calcitonin gene-related peptide causes gubernacular development in neonatal (Tfm) mice with complete androgen resistance. Griffiths AL, Middlesworth W, Goh DW, Hutson JM. J Pediatr Surg. 1993 Aug;28(8):1028-30.

Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Kunkel LM, Hejtmancik JF, Caskey CT, Speer A, Monaco AP, Middlesworth W, et al. Nature. 1986 Jul 3-9;322(6074):73-7.

An RFLP detecting single copy X-chromosome fragment, dic56, from Xp22-Xpter [HGM8 assignment no. DXS 143]. Middlesworth W, Bertelson C, Kunkel LM. Nucleic Acids Res. 1985 Aug 12;13(15):5723.

Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment. Monaco AP, Bertelson CJ, Middlesworth W, Colletti CA, Aldridge J, Fischbeck KH, Bartlett R, Pericak-Vance MA, Roses AD, Kunkel LM. Nature. 1985 Aug 29-Sep 4;316(6031):842-5.

Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion. Kunkel LM, Monaco AP, Middlesworth W, Ochs HD, Latt SA. Proc Natl Acad Sci U S A. 1985 Jul;82(14):4778-82.

Construction of a human X-chromosome-enriched phage library which facilitates analysis of specific loci. Kunkel LM, Lalande M, Monaco AP, Flint A, Middlesworth W, Latt SA. Gene. 1985;33(3):251-8.

AbstractsRegression of Established Hepatoblastoma Xenografts Using a Novel VEGF-Blocking Agent. Kimberly W. McCrudden, Jason Frischer, Jianzhong Huang, Anna Novikov, Darrell J. Yamashiro, Jessica J. Kandel, William Middlesworth . Presented at the 2002 AAP Surgical Section, October 19, 2002.

Development of a Metastasizing Model of Hepatoblastoma and Inhibition of Xenograft Growth by Anti-Angiogenic Therapy with Topotecan. Kimberly W. McCrudden, Akiko Yokoi, Amit J. Thosani, Eugene S. Kim, Samuel S. Soffer, Jianzhong Huang, Christina A. Manley, Kathleen O'Toole, Darrell J. Yamashiro, Jessica J. Kandel, Charles J. Stolar, William Middlesworth . (Abstract 1196). Presented at the 2001 meeting of the Pediatric Academic Societies, April 30, Baltimore, MD.

Duodenal Atresia with proximal jejeunal perforations. William Middlesworth . Presented at the American College of Surgeons Clinical Congress, October 7, 2001, New Orleans, LA.