Kalfa Lab

David Kalfa, MD, PhDPI: David Kalfa, MD, PhD


P&S Building – 630 W 168th Street, 15-401
New York, NY 10032


The research in Kalfa’s Lab is focused on mechanical engineering and tissue engineering approaches to improve the clinical outcomes and quality of life of children with congenital heart defects. We investigate experimental and computational innovative technologies to offer personalized treatment modalities to children with congenital heart defects, applying the concepts of regenerative medicine and precision medicine to the field of congenital cardiac surgery. Our laboratory has a highly multidisciplinary profile and integrates the use of fabrication processes (dip molding, electrospinning, extrusion) and computational modeling along with experimental mechanics, tissue engineering, valve biology and design optimization techniques. Our long-term goals are to develop growth-accomodating pediatric medical devices to address valve-related and heart failure-related unmet clinical needs. Our laboratory is a home to the Translational Research activity of the Columbia Pediatric Heart Valve Center founded to improve the quality of care for children and adults with congenital heart valve malformations. We are actively collaborating with numerous investigators at Columbia University, nationwide and throughout the world.

Lab Members

  • Mingze Sun, PhD – Postdoctoral Research Scientist
  • Maryam Haghihiabyaneh, PhD – Postdoctoral Research Fellow
  • Eliana Al Haddad, PhD – Postdoctoral Research Fellow
  • Richard Leechung Li – PhD student