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Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Chronic Hepatitis C Participants With Child-Pugh (CP)-B Hepatic Insufficiency
… of MK-5172 and MK-8742 ± Ribavirin (RBV) in Subjects with Chronic Hepatitis C Virus Infection with Advanced … and Child-Pugh (CP)-B Hepatic Insufficiency This study is being done to evaluate the efficacy and safety of the drug … elbasvir at the beginning of the study; this will be done for the purpose of collecting plasma pharmacokinetic data in …
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Intranasal Oxytocin Use in Identifying the Micro-RNA Fingerprint in NAF, Serum, and Tissue in Patients with DCIS or Invasive Breast Cancer
… aspirate fluid (NAF), serum, and tissue of women diagnosed with DCIS or invasive breast cancer. Because 90% of breast cancers originate from ductal epithelium, it is possible that cells and secretions collected from such ducts would allow for earlier detection of breast cancer. Ideally, NAF may be …
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A Phase 1 First-in-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 228 in Subjects with Selected Advanced Solid Tumors
… The purpose of this study is to find out more about the effects of AMG 228 in people … cancer, melanoma, colon cancer, or bladder cancer. AMG 228 is an experimental drug that is being developed to stimulate … This study will look at what doses of AMG 228 are safe for people to take and whether it causes any side effects. …
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A pilot study to determine the safety of recovered blood intended for auto- transfusion during pancreatic cancer operations
… of autologous blood transfusions following pancreatectomy for pancreatic ductal adenocarcinoma (PDAC) … study to determine the safety of recovered blood intended for auto- transfusion during pancreatic cancer operations …
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A Randomized, DoubleBlind, Controlled Evaluation of Tenofovir DF versus Adefovir Dipivoxil for the Treatment of HBeAg Positive Chronic Hepatitis B
… This study is designed to evaluate the safety and antiviral activity of … (TDF, tenofovir DF) compared to adefovir dipivoxil (ADV) for the treatment of HBeAg-positive chronic hepatitis B. … Evaluation of Tenofovir DF versus Adefovir Dipivoxil for the Treatment of HBeAg Positive Chronic Hepatitis B …
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Safety and Efficacy of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Participants With Chronic Hepatitis C and Chronic Kidney Disease (MK-5172-052) (C-SURFER)
… the Combination Regimen of MK-5172 and MK-8742 in Subjects with Chronic Hepatitis C Virus Infection and Chronic Kidney … treatment with grazoprevir (MK-5172) + elbasvir (MK-8742) for cirrhotic and non-cirrhotic participants with chronic … pharmacokinetic sampling. The primary study hypothesis is that the proportion of participants achieving a sustained …
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A Prospective, Multicenter, Non-Blinded, Non-Randomized Study of the Relay PRO Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers
… This trial is a prospective, multicenter, non-blinded, non-randomized … study of the Relay PRO Thoracic Stent-Graft in subjects with Thoracic Aortic Aneurysms (TAAs) and Penetrating … Atherosclerotic Ulcers (PAUs) The purpose of this study is to investigate the safety and effectiveness of the Relay …
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A Phase II Study of Chemotherapy and Immune Checkpoint Blockade With Pembrolizumab in the Perioperative and Maintenance Treatment of Locoregional Gastric or GE Junction Adenocarcinoma
… This study is done to determine and evaluate the efficacy of combination therapy with immune checkpoint blockade and chemotherapy used in the … II Study of Chemotherapy and Immune Checkpoint Blockade With Pembrolizumab in the Perioperative and Maintenance …
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A Phase II Randomized Multicenter Placebo- Controlled Blinded Study of Sorafenib Adjuvant Therapy in High Risk Orthotopic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC)
… The purpose of this study is to determine if sorafenib (sorafenib tosylate) is a safe and effective treatment option for preventing liver cancer in high risk patients following … in High Risk Orthotopic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC) …
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Preoperative Extended Chemotherapy Vs Chemotherapy Plus Hypofractionated Radiation Therapy For Borderline Resectable Adenocarcinoma Of The Head Of The Pancreas
… Vs Chemotherapy Plus Hypofractionated Radiation Therapy For Borderline Resectable Adenocarcinoma Of The Head Of The …
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Open-Label, Dose-Escalation Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Daily Oral MGCD265 Administered Without Interruption to Patients with Advanced Malignancies
… The purpose of this research study is to find the highest safe dose of the drug MGCD265 that can be given to participants with advanced cancer. The safety of this drug, and the effect … a drug that works by blocking proteins that are important for cancer cells to grow. MGCD265 also prevents the growth of …
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A Long Term Follow-up Registry Study of Subjects Who Did Not Achieve Sustained Virologic Response in Gilead-Sponsored Trials in Subjects with Chronic Hepatitis C Infection
… This Registry is designed to obtain long term data on participants who have … Virologic Response in Gilead-Sponsored Trials in Subjects with Chronic Hepatitis C Infection …
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Master regulator analysis to prioritize treatment of residual disease following neoadjuvant chemotherapy for breast cancer in patient-derived tumor xenografts
… from tumors resistant to neoadjuvant taxane therapy [i.e. paclitaxel or docetaxel +/- adriamycin/cytoxan] as compared to taxane (i.e. control). … of residual disease following neoadjuvant chemotherapy for breast cancer in patient-derived tumor xenografts …
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Phase II Preopertaive Extended Chemotherapy vs. Chemotherapy Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas
… vs. Chemotherapy Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the …
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A Randomized Trial Comparing the ELUVIA™ Drug-eluting Stent Versus Zilver® PTX® Stent for Treatment of Superficial Femoral and/or Proximal Popliteal Arteries
… This trial will be comparing the Eluvia stent with the Zilver PTX stent in patients with chronic, symptomatic atherosclerosis of the lower extremities. The primary objective of this trial is to evaluate the safety and effectiveness of the ELUVIA … the ELUVIA™ Drug-eluting Stent Versus Zilver® PTX® Stent for Treatment of Superficial Femoral and/or Proximal …
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