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A Phase 1 Multiple Ascending Dose Study Of DS-3032b, An Oral MDM2 Inhibitor, In Subjects With Advanced Solid Tumors Or Lymphomas

… This Phase I research study is for individuals with advanced melanoma or lymphoma. The purpose of this study is to determine and confirm the safety and tolerance of a … has been established in Part 1 dose escalation, so Part 2 is to confirm those in the intended population. DS ‐ 3032b is …

Last Modified: 02/13/2023 - 21:06

Secondary Hyperparathyroidism

… Team , October 2024 About Secondary hyperparathyroidism is a condition in which a disease outside of the parathyroid … and vitamin D deficiency. In kidney failure, the kidney is no longer able to make enough vitamin D or remove all of the phosphorus that is made by the body, which leads to low calcium levels. These …

Last Modified: 09/26/2025 - 11:10

Valve Sparing Aortic Root Replacement (David Procedure)

… operation, Tirone David, MD), the patient's aortic valve is kept (although it may be repaired and reimplanted) and … lifelong anticoagulation therapy (coumadin). The patient is placed on the heart-lung machine (cardiopulmonary bypass), … heart and lungs during the operation. Step 1 : The heart is cooled and stopped and a clamp is placed across the aorta. …

Last Modified: 02/02/2026 - 14:58

State of the Union: Lung and Chest Care in 2021

… previously untreatable. On every front, thoracic surgery is making remarkable and profound progress. In terms of … new methods of diagnosing? Are tests more sensitive or is it all about early intervention? Diagnosing earlier—we're … surgery—are still trying to assess and/or repair lungs on site presently. And the ability to do that should rapidly …

Last Modified: 02/23/2023 - 18:02

Botox Injection

… of Columbia’s Plastic Surgery Team, May 2025 Botox is a non-invasive cosmetic procedure that injects a small … cosmetic procedure for both men and women. Botox is also used to treat conditions like hyperhidrosis (excess … include: Pain, swelling, or bruising at the injection site Drooping eyelids Asymmetries In rare cases, side effects …

Last Modified: 10/28/2025 - 18:23

Gastric Bypass Surgery

… surgeon Francisco Guzman, MD , January 2025 Gastric bypass is a surgical procedure that induces weight loss by changing … of the digestive tract. Key Facts Gastric bypass surgery is one of the most common weight loss surgeries in the United … may not be tolerated well. Complications at Reconnection Site – Long-term complications related to intestinal …

Last Modified: 11/12/2025 - 13:43

Graves’ Disease

… of Columbia’s Thyroid Surgery Team , October 2024 What is Graves’ Disease? Graves’ disease is an autoimmune disorder that affects the thyroid gland, the … changes. Such symptoms may occur before or after a person is diagnosed with Graves’ disease. In many cases, these …

Last Modified: 09/26/2025 - 10:57

Intraoperative Radiation Therapy for Breast Cancer

… explains how Intraoperative Radiation Therapy (IORT) is administered, its potential benefits, and eligibility. Key Info IORT involves a single dose of radiation that is administered immediately after a lumpectomy. Compared with … How Intraoperative Radiation Therapy Works A lumpectomy is a common procedure for patients with early stage breast …

Last Modified: 09/22/2025 - 12:55

Angioplasty

… Angioplasty is a nonsurgical procedure to open blocked or narrowed … coronary intervention (PCI) or balloon angioplasty, it is used to treat severely blocked coronary arteries as well … through the artery to the area of blockage. The balloon is inflated, flattening the fatty deposits and widening the …

Last Modified: 12/16/2025 - 16:13

Myocarditis

… Myocarditis is an inflammation of the heart muscle, usually as a result … of the world (and previously in the United States), TB is a common cause of pericarditis. How is Myocarditis Diagnosed? Myocarditis may start with flulike …

Last Modified: 12/16/2025 - 15:28

Being A Woman Surgeon: Sixty Women Share Their Stories

… Christine Rohde, MD, MPH, FACS , is one of 60 surgeons to share their experiences in Being A … wide acclaim from readers and reviewers. Dr. Rohde is Chief of Microvascular Services and Associate Professor in … best-selling author Atul Gawande, MD, writes, "This book is an enthralling read. It is all too rare to hear the …

Last Modified: 02/19/2023 - 13:11

Bariatric Surgery FAQs

… and after surgery. For this meeting with the dietician, it is a good idea to bring a list of everything you have eaten … of the tests that he/she has recommended that you do, it is then that our office will schedule an appointment to meet … case. Most patients then decide which weight loss surgery is best for them. If you are still undecided, you do not need …

Last Modified: 11/05/2025 - 15:28

A Biomimetic Patch Could Soon Change the Way We Do Heart Valve Repairs

… David Kalfa, MD, is a pediatric heart surgeon with a PhD in tissue … malformations currently? Malformation of heart valves is very frequent in children, and there are different ways to … augmentation of the leaflet or leaflet replacement. There is another situation where we have to replace the valve, but …

Last Modified: 07/07/2025 - 16:08

Pediatric Heart Valve Center

… The Pediatric Heart Valve Center at Columbia is dedicated to improving the quality of care for children … safer treatment options. The Pediatric Heart Valve Center is one of the largest and most successful centers for … Valve The most common aortic valve lesion in childhood is aortic stenosis. Left ventricular outflow tract (LVOT) …

Last Modified: 01/21/2026 - 18:33