Determine whether master regulator-directed therapy will demonstrate a greater reduction of tumor growth in patient-derived xenografts from tumors resistant to neoadjuvant taxane therapy [i.e. paclitaxel or docetaxel +/- adriamycin/cytoxan] as compared to taxane (i.e. control).
The Zenith® Branch Endovascular Graft-Iliac Bifurcation (Branch Graft) is intended to preserve flow to the internal iliac artery (IIA) as part of endovascular aneurysm repair of aortoiliac or iliac artery aneurysms
The HeartMate III Left Ventricular Assist System (LVAS) is a prospective, multi-center, study comparing the HeartMate III LVAS to the HeartMate II® LVAS in advanced stage heart failure patients. The study will be conducted as a staged pivotal study that includes a pre-specified early assessment for safety. Researchers at up to 60 centers will evaluate the device for use as long-term support for patients who are not candidates for cardiac transplant (also known as Destination Therapy).
The goal of this research is to gain information whether a calcium sensing enzyme called "Calcium/Calmodulin Dependent Protein Kinase" is activated in obesity. This research will supplement additional information about the pathogenesis of insulin resistance associated with obesity.
Human donor lungs that do not meet the standard clinical criteria for donor lung utilization but fit into the study inclusion criteria will be retrieved from the donor using current donor lung retrieval techniques.