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A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies
… This is a phase 1/1b research study for adults with a diagnosis of … drug called MGCD516. Investigational means that MGCD516 is not approved by the U.S. Food and Drug Administration (FDA). MGCD516 is designed to block specific tyrosine kinases, which are …
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A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenoca
… The purpose of this study is to compare the efficacy and safety of PEGPH20 combined … untreated pancreatic ductal adenocarcinoma. This study is for adult patients with stage IV pancreatic cancer. The purpose of the study is to compare the efficacy (how well the drug works) and …
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COVID-19 Update from Dr. Smith: 3/22/20
… outside the family find value in some parts of the message is a welcome bonus, and perhaps a reminder that even Surgeons … the same issues that perplex the rest of the world. There is nothing new to report on the sobering slope of the new-case rate. Testing is still significantly limited by availability of swabs, …
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A Phase 1 Multiple Ascending Dose Study Of DS-3032b, An Oral MDM2 Inhibitor, In Subjects With Advanced Solid Tumors Or Lymphomas
… This Phase I research study is for individuals with advanced melanoma or lymphoma. The purpose of this study is to determine and confirm the safety and tolerance of a … has been established in Part 1 dose escalation, so Part 2 is to confirm those in the intended population. DS ‐ 3032b is …
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Being A Woman Surgeon: Sixty Women Share Their Stories
… Christine Rohde, MD, MPH, FACS , is one of 60 surgeons to share their experiences in Being A … wide acclaim from readers and reviewers. Dr. Rohde is Chief of Microvascular Services and Associate Professor in … best-selling author Atul Gawande, MD, writes, "This book is an enthralling read. It is all too rare to hear the …
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Beach Friendly Snacks
… By Danielle Staub, MS, RD, CDN Summer is not over yet—soak up the last few weeks with a trip to the … refreshing and of course very nourishing. The key is planning ahead and making sure to bring the essentials. … Veggies and Hummus The great thing about vegetables is that they’re hydrating . Celery is 96% water, bell …
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A Phase II Randomized Multicenter Placebo- Controlled Blinded Study of Sorafenib Adjuvant Therapy in High Risk Orthotopic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC)
… The purpose of this study is to determine if sorafenib (sorafenib tosylate) is a safe and effective treatment option for preventing liver … following liver transplantation. Liver transplantation is a treatment option for liver cancer patients, but despite …
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PRO 02/ML28897 MY PATHWAY STUDY: An Open-Label Phase IIA Study Evaluating Trastuzumab/ Pertuzumab, Erlotinib, Vermurafenib, and Vismodegib in Patients Who Have Advanced Solid Tumors with Mutations or Gene Expression Abnormalities Predictive of Response to
… are not available, and in whom a trial of targeted therapy is considered the best available treatment option. Erlotinib is a targeted drug that blocks the activity of epidermal … in high quantities in HER2-positive cancers. Pertuzumab is believed to work in a way that is complementary to …
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Other Things You Will Want to Know Beforehand
… clinical clerkships, medical students often ask, “What is expected of me?” The reply is vague, predictable, uninformative, and often frustrating: … and left to figure out what they actually mean. Here is a list of 10 (plus one) things to do on your surgery …
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Investigation of Calcium/Calmodulin Dependent Protein Kinase II (CaMKII) activity in human liver tissue.
… The goal of this research is to gain information whether a calcium sensing enzyme … called "Calcium/Calmodulin Dependent Protein Kinase" is activated in obesity. This research will supplement … of insulin resistance associated with obesity. Obesity is associated with insulin resistance, disturbed glucose …
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Obesity Surgery Transforms Lives: A Patient Experience
… after surgery, which she had in September, 2000, she is down to 170 and is thrilled that she can buy size 10 clothing. "I have had no … no heartburn since I woke up from the surgery." Lynda is a dental hygienist who has had a lifelong weight problem. …
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Hyesoo Lowe, MD
… Hyesoo Lowe, MD is a board-certified Endocrinologist at Columbia University, … Endocrinology at Columbia University Medical Center. She is actively involved in medical student education at the … University Vagelos College of Physicians and Surgeons, and is also on the teaching faculty of the Endocrinology …
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Sugar and Cancer
… CDN One commonly asked question asked by oncology patients is “Does Sugar Feed Cancer?” Eating sugar can be a source of … up, there are lots of delicious sweets around, so now is the perfect time to address this topic. Currently, there is no evidenced based research to show sugar causes cancer. …
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An Interview with Zofia Morena, Ralph Lauren Fashion Model, Philanthropist, and Entrepreneur, on Overcoming Hyperparathyroidism
… Zofia Morena is a successful fashion model, entrepreneur, philanthropist, … devotee of wellness and integrative lifestyles. She is married with two boys. But despite a successful, … tired. And one of the symptoms of hyperparathyroidism is being tired. Plus, I wouldn’t sleep. My sleep deprivation …
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Guide to the Aorta
… What is the Aorta? To understand the aorta, it helps to have a … can deliver that oxygen to the rest of the body. The Aorta is the first and largest part of the artery system . All … off branches of the aorta, like exits on a highway. Where is the Aorta? The aorta runs right down the middle of your …
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