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A randomized, double-blind, placebo-controlled, phase II study of sorafenib in subjects with hepatopulmonary syndrome
… the safety and effects of the study drug, sorafenib, in adults diagnosed with hepatopulmonary syndrome (HPS). The … drug is tolerated and its effect on the level of oxygen in the blood and the function of the lung vessels. Trial … placebo-controlled, phase II study of sorafenib in subjects with hepatopulmonary syndrome …
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Simtuzumab (GS-6624) in Treatment of Advanced Liver Fibrosis But Not Cirrhosis Secondary to NASH
… Monoclonal Antibody Against Lysyl Oxidase-Like 2 (LOXL2), in Subjects with Advanced Liver Fibrosis but not Cirrhosis … liver fibrosis and the clinical progression to cirrhosis in participants with non-alcoholic steatohepatitis (NASH). It … Simtuzumab (GS-6624) in Treatment of Advanced Liver Fibrosis But Not Cirrhosis …
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A Trial of IDN-6556 in Post Orthotopic Liver Transplant for Chronic HCV (POLT-HCV-SVR)
… Multicenter, Double-Blind, Sponsor-Open Trial of IDN- 6556 in Subjects Who had Hepatitis C Virus (HCV) Reinfection and … to see if treatment with IDN-6556 is better than placebo in reversing or stopping the progression of the damage to the … A Trial of IDN-6556 in Post Orthotopic Liver Transplant for Chronic HCV …
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A Phase I/II Dose Escalation and Cohort Expansion Study of the Safety, Tolerability and Efficacy of Anti-CD27 Antibody (Varlilumab) Administered in Combination with Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
… antibodies (types of human protein) that are manufactured in a laboratory and are being tested to see if they will … time varlilumab and nivolumab have been tested together in humans. Using similar agents in cancer models in mice showed that combining the treatments …
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A 24-month, multi-center, single arm, prospective study to evaluate renal function, efficacy, safety and tolerability of everolimus in combination with reduced exposure cyclosporine or tacrolimus in paediatric liver transplant : CRAD001H2305
… efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients. Trial Website: … function, efficacy, safety and tolerability of everolimus in combination with reduced exposure cyclosporine or tacrolimus in paediatric liver transplant : CRAD001H2305 …
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A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenoca
… of PEGPH20 combined with nab-paclitaxel & gemcitabine in participants with hyaluronan (HA)-high Stage IV previously … and water with an amount of salt similar to body fluids) in combination with two chemotherapy drugs nab-paclitaxel … A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared …
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A Phase 1, Open-Label, Dose Escalation Study of MGA271 in Combination with Ipilimumab in Patients with B7-H3-Expressing Melanoma, Squamous Cell Cancer of the Head and Neck or Non Small Cell Lung Cancer
… safety, tolerability, and most effective dose of MGA271 in combination with ipilimumab (also called Yervoy®). MGA271 … (FDA). Ipilimumab is approved by the FDA for use in melanoma patients, but it is experimental for NSCLC and … is the first time that MGA271 and ipilimumab will be given in combination. At the beginning of the study, 3-9 patients …
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Overhaul in the Treatment of Kidney Disease is Long Overdue, Kidney Transplant Surgeon Explains the Importance
… Three main issues plague the way we treat kidney disease in the United States: the business of dialysis, access to kidney transplants, and monetary barriers that stand in the way of donating a kidney to someone in need. A new executive order pledges to reduce end stage …
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Serum Lipopolysaccharide (LPS) Measurement to Predict Progression of Fibrosis in Liver Transplant Recipients with Hepatitis C Virus
… (LPS) Measurement to Predict Progression of Fibrosis in Liver Transplant Recipients with Hepatitis C Virus. … (LPS) Measurement to Predict Progression of Fibrosis in Liver Transplant Recipients with Hepatitis C Virus …
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Family and Personal History of Pancreatic and Other Malignancies in Patients with Intraductal Papillary Mucinous Neoplasms
… and Personal History of Pancreatic and Other Malignancies in Patients with Intraductal Papillary Mucinous Neoplasms …
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A Phase 1 Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Oral Doses of the Glutaminase Inhibitor CB-839, as a Single Agent and in Combination with Standard Chemotherapy in Patients with Advanced/Treatment-Refractory Solid Tumors
… or refractory solid tumors (cancer that continues to grow in spite of receiving standard treatment) respond to … drug by analyzing biomarkers. Biomarkers are substances in your body that can be used to detect a disease or to find out how the cancer is responding to treatment. In this study, biomarkers found in tumor tissue and blood …
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New Interventional Techniques Eliminate the Need for Thyroid Surgery in Nearly One-Third of Patients with Nodules
… 65 percent of people will have a thyroid nodule in their lifetime. Not everyone will have a large nodule, … it is going to be a good treatment for a lot of people.” In this interview, Dr. Kuo discusses the new Interventional … waves allow us to burn the tissue we’re targeting in a very controlled manner. It’s a very similar concept to …
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A Randomized Phase II Study of Temozolomide or Temozolomide and Capecitabine in Patients with Advanced Pancreatic Neuroendocrine Tumors
… tumors cancer to find out which is more effective. In this study, participants will get either temozolomide … by the FDA to treat pancreatic neuroendocrine cancer. In addition to learning more about these chemotherapy drugs, … Investigators will specifically be looking for changes in a gene called MGMT to see if these changes predict for …
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After Breast Cancer Twice in One Year, Early Detection and New Radiation Therapy Made All the Difference
… her annual wellness appointments to fall six months in between. The way she puts it, “somebody was squeezing my … my life I assumed it was going to happen at some point in the future,” she explains. The future showed up earlier … her phone rang. “They told me to come back. I went right in that same day, and they did a bunch more tests: …
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A Study of RO6958688 in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen Positive Solid Tumors
… CEA on the tumor cells and may activate the immune system in targeting cancer cells. The study will also explore how the study drug works in the body and on the tumor. The study also wants to find … A Study of RO6958688 in Participants With Locally Advanced and/or Metastatic …
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