Search results

A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies

… This is a phase 1/1b research study for adults with a diagnosis of … drug called MGCD516. Investigational means that MGCD516 is not approved by the U.S. Food and Drug Administration (FDA). MGCD516 is designed to block specific tyrosine kinases, which are …

Last Modified: 02/13/2023 - 21:06

Liver Transplantation

… A liver transplantation is a surgery that removes a diseased or malfunctioning liver … a healthy donor liver from another person. Because there is currently no artificial solution that can fully replace the liver, transplantation is the only viable cure for liver failure. Key Facts Liver …

Last Modified: 02/23/2026 - 15:20

Peripheral arterial disease (PAD) may be one of the most common health problems you’ve never heard of

… Surgery and Endovascular Interventions , explains that PAD is significantly underdiagnosed, despite a steady increase in … or a loved one has any of the risk factors for PAD, here is what you need to know. What causes PAD? PAD is caused by the buildup of fatty deposits or plaques in the …

Last Modified: 02/23/2023 - 18:00

Advances in Mitral Valve Surgery

… The mitral valve is like a one-way door between chambers of the heart; it … has emerged as an alternative to valve replacement, and is linked to improved long-term survival in many patients. … , Section Chief of Adult Cardiac Surgery , “Mitral repair is clearly superior to replacement for most patients with …

Last Modified: 02/23/2023 - 18:00

Should I follow a Whole Food, Plant-Based Diet?

… through various documentaries and media outlets. What is a Plant-Based Diet? There are many viewpoints as to what … a whole food plant-based diet, however the main principle is focused on the potential to maximize the consumption of … By simply focusing on plants, intake of saturated fats is significantly reduced while essential vitamins, minerals, …

Last Modified: 02/23/2023 - 18:01

A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenoca

… The purpose of this study is to compare the efficacy and safety of PEGPH20 combined … untreated pancreatic ductal adenocarcinoma. This study is for adult patients with stage IV pancreatic cancer. The purpose of the study is to compare the efficacy (how well the drug works) and …

Last Modified: 02/13/2023 - 21:07

Pancreatitis Treatments

… (IV) nutrition, antibiotics, and pain medications. Surgery is sometimes needed to treat complications. Treatment for … stomach or small intestines. Sometimes enteral nutrition is contraindicated or not tolerated. Under these circumstances, parenteral (intravenous) nutrition is indicated, and is better than no nutrition. Stents The …

Last Modified: 09/24/2025 - 13:01

Naltrexone Implant a Powerful New Tool in the Fight Against Opioid Addiction

… adapts; and feelings of euphoria dampen. Now, the opioid is creating new circuits, altering neural pathways little by little. With every high, your brain is rewired to chase that flood of dopamine, eventually … someone addicted to opioids in the United States. One is to prescribe methadone, a treatment that replaces the …

Last Modified: 02/23/2023 - 18:01

Pheochromocytoma

… and amount of energy available to the body. Adrenaline is the most common and well-known catecholamine. The adrenal … extra adrenaline in response to stress. This increase is known as the "fight or flight response"—i.e. the body is … sympathetic nervous chain. The most common extra-adrenal site is a point on the abdominal aorta (the largest artery in …

Last Modified: 09/24/2025 - 13:43

COVID-19 Update from Dr. Smith: 3/22/20

… outside the family find value in some parts of the message is a welcome bonus, and perhaps a reminder that even Surgeons … the same issues that perplex the rest of the world. There is nothing new to report on the sobering slope of the new-case rate. Testing is still significantly limited by availability of swabs, …

Last Modified: 02/23/2023 - 18:01

Alpha-1 Antitrypsin Deficiency

… Alpha-1 antitrypsin (AAT) deficiency is an inherited condition that can cause serious lung and … of the AAT protein. Key Facts Alpha-1 antitrypsin (AAT) is one of several proteins the liver produces and releases … vulnerable to damage and harms the liver. AAT deficiency is a genetic condition, which means it is passed down from …

Last Modified: 01/12/2026 - 11:31

Hemochromatosis

… Hemochromatosis is a metabolic disease in which iron is absorbed from the digestive tract and deposited in tissues … conditions like cirrhosis and diabetes. Hemochromatosis is often an inherited condition, which means it is caused by …

Last Modified: 01/12/2026 - 11:36

Hyperthyroidism

… hormone or by release of thyroid hormone as the gland is destroyed. An overactive thyroid is the most common cause of hyperthyroidism and can be caused … known as diffuse toxic goiter or when the whole thyroid is hyperactive), toxic multinodular goiter (when more than …

Last Modified: 10/01/2025 - 12:12

Secondary Hyperparathyroidism

… Team , October 2024 About Secondary hyperparathyroidism is a condition in which a disease outside of the parathyroid … and vitamin D deficiency. In kidney failure, the kidney is no longer able to make enough vitamin D or remove all of the phosphorus that is made by the body, which leads to low calcium levels. These …

Last Modified: 09/26/2025 - 11:10

State of the Union: Lung and Chest Care in 2021

… previously untreatable. On every front, thoracic surgery is making remarkable and profound progress. In terms of … new methods of diagnosing? Are tests more sensitive or is it all about early intervention? Diagnosing earlier—we're … surgery—are still trying to assess and/or repair lungs on site presently. And the ability to do that should rapidly …

Last Modified: 02/23/2023 - 18:02