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Open-Label, Dose-Escalation Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Daily Oral MGCD265 Administered Without Interruption to Patients with Advanced Malignancies

… The purpose of this research study is to find the highest safe dose of the drug MGCD265 that can … disease and your body will also be studied. MGCD265 is a drug that works by blocking proteins that are important … MGCD265 an investigational agent. This means that MGCD265 is not approved by the Food and Drug Administration (FDA). …

Last Modified: 02/13/2023 - 21:06

A Study of RO6958688 in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen Positive Solid Tumors

… The purpose of this study is to find out which doses of the study drug are safe to give … liver, pancreas, stomach) solid tumors. The study drug is RO6958688. RO6958688 is an antibody that targets CEA on the tumor cells and may …

Last Modified: 02/19/2023 - 13:11

Jennifer Hong Kuo, MD

… Dr. Jennifer H. Kuo is a board-certified surgeon-scientist nationally recognized … in thyroid, parathyroid, and adrenal surgery. She is a high-volume, minimally invasive surgeon specializing in … as transoral thyroidectomy and robotic adrenalectomy, and is an internationally recognized leader in ultrasound-guided …

Last Modified: 03/05/2026 - 09:35

Research/Academic Time

… While we believe dedicated academic time is important to the professional development of our residents, our flexibility during this period is one of the hallmarks of our program. In the past 10 years, … PGY1 to establish a plan for their academic years if this is desired. Residents choosing to pursue an academic year or …

Last Modified: 01/22/2026 - 18:00

Joshua R. Sonett, MD

… Joshua R. Sonett MD FACS is the Edward C. and Anne K. Weiskopf Professor of Surgical … Comprehensive Chest Care, Lung and Esophageal Center. He is instrumental in making the Thoracic Surgery section at … Medical Center one of the best in the U.S. and he is one of the youngest professors of surgery at a major …

Last Modified: 03/05/2026 - 09:35

Your Kidney Transplant

… your options and tell you whether kidney transplantation is the best option for you. A new kidney may be donated by a … your operation Once you are on the UNOS waiting list, it is important that you keep your transplant coordinator … Program doesn't require that you relocate, but time is of the essence, and you must be able to reach our hospital …

Last Modified: 01/12/2026 - 11:27

Hiatal Hernia

… a hiatal hernia. Sliding Hiatal Hernia The term sliding is employed when hiatal hernia involves the lower esophageal … reflux may damage the lining of the esophagus, treatment is essential. Symptoms can usually be managed with … by Lyall A. Gorenstein, MD » Risk Factors Hiatal hernia is initiated by pressure in the abdomen occurring through: …

Last Modified: 11/05/2025 - 17:01

Guide to Aortic Aneurysm

… What is an aortic aneurysm? An aortic aneurysm occurs when the … thoracic aorta, or the abdominal aorta. How common is an aortic aneurysm? Aortic aneurysms have an incidence of … to lifestyle factors. One of the major factors is age; over time, the aorta naturally loses its elasticity, …

Last Modified: 02/03/2026 - 12:06

Guide to Breast Screening and Prevention

… options and preventative measures you can take. What Is Breast Screening? Breast screening involves checking your … other disease before there are any signs or symptoms. It is the primary method of detecting disease early and … ultrasonography, and breast MRIs: Mammography : This is the gold standard of breast screening. It involves a …

Last Modified: 09/22/2025 - 12:54

Breast Reconstructive Surgery

… for each. Key Info Breast reconstructive surgery is a procedure that can rebuild a portion of a breast or … can consist of skin, fat, and sometimes muscle. Because it is a more complex procedure than implant reconstruction, it … surgery are complete. For example, radiation therapy is often required after breast cancer surgery. This is …

Last Modified: 09/22/2025 - 12:55

Vascular Surgeon Draws on the Art of Surgery in His Own Way

… sketches. In complex aortic procedures , reconstruction is rarely, if ever, straight forward. The map of a person’s vasculature is largely unique; its pathways elaborate and far-reaching. And the aorta is at the center, the largest artery, responsible for …

Last Modified: 09/30/2024 - 09:25

Clinical Training

… The Columbia General Surgery Residency is a robust clinical experience both in and out of the OR. … Throughout the course of the training program, emphasis is placed on the development of technical skills through a … in the clinic, floor, and ICU settings. The program is designed to give residents a gradual increase in …

Last Modified: 02/19/2023 - 13:11

NYP/Columbia’s Center for Motility and Neurogastroenterology

… general thoracic surgeon Frank D’Ovidio, MD, PhD , is collaborating with gastroentereologists David Markowitz, … motility disorders. A wide range of services is now offered by a panel of experts at the Center for … may go onto need a lung transplant as well. Dr. D’Ovidio is also surgical director of Columbia’s nationally recognized …

Last Modified: 02/23/2023 - 18:00

Tomoaki Kato, MD

… Tomoaki Kato, MD, is a noted pioneer in multiple-organ transplantation, … pediatric and adult liver transplantation. Dr. Kato is Vice Chair for Transplantation at … University Irving Medical Center and is a professor of surgery at Columbia University Vagelos College of Physicians and Surgeons. Dr. Kato is known for unique and innovative surgeries for adults and …

Last Modified: 03/05/2026 - 09:35

William Middlesworth, MD

… committees focused on Quality and Patient Safety, and is the Vice Chair for Quality and Patient Safety for Columbia's Department of Surgery. He is the Surgeon Champion at the Columbia campus for the … harm and enhance safety in the peri-operative setting that is sponsored by MCIC Vermont, the member-owned malpractice …

Last Modified: 03/04/2026 - 08:37